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[JAMA发表论文]:医院普通病房患者的电子脓毒症预警
2024年12月20日 时讯速递, 进展交流 [JAMA发表论文]:医院普通病房患者的电子脓毒症预警已关闭评论

Original Investigation 

Caring for the Critically Ill Patient

December 10, 2024

Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial

Yaseen M. Arabi, Abdulmohsen Alsaawi, Mohammed Alzahrani, et al

JAMA. Published online December 10, 2024. doi:10.1001/jama.2024.25982

Key Points

Question  Does electronic sepsis screening based on quick Sequential Organ Failure Assessment score (qSOFA), compared with no screening, reduce the mortality of patients admitted to hospital wards?

Findings  In a stepped-wedge, cluster randomized trial at 45 wards (clusters) in 5 hospitals in Saudi Arabia, 29 442 patients were in the screening group and 30 613 in the no screening group. Accounting for period, clustering within wards, hospitals, and COVID-19 status, electronic sepsis screening significantly reduced in-hospital mortality within 90 days compared with no screening (adjusted relative risk, 0.85).

Meaning  In hospitalized ward patients, electronic sepsis screening compared with no screening resulted in reduced 90-day in-hospital mortality.

Abstract

Importance  Sepsis screening is recommended among hospitalized patients but is supported by limited evidence of effectiveness.

Objective  To evaluate the effect of electronic sepsis screening, compared with no screening, on mortality among hospitalized ward patients.

Design, Setting, and Participants  In a stepped-wedge, cluster randomized trial at 5 hospitals in Saudi Arabia, 45 wards (clusters) were randomized into 9 sequences, 5 wards each, to have sepsis screening implemented at 2-month periods. The study was conducted between October 1, 2019, and July 31, 2021, with follow-up through October 29, 2021.

Intervention  An electronic alert, based on the quick Sequential Organ Failure Assessment score, was implemented in the electronic medical record in a silent mode that was activated to a revealed mode for sepsis screening.

Main Outcomes and Measures  The primary outcome was 90-day in-hospital mortality. There were 11 secondary outcomes, including code blue activation, vasopressor therapy, incident kidney replacement therapy, multidrug-resistant organisms, and Clostridioides difficile.

Results  Among 60 055 patients, 29 442 were in the screening group and 30 613 in the no screening group. They had a median age of 59 years (IQR, 39-68), and 30 596 were male (51.0%). Alerts occurred in 4299 of 29 442 patients (14.6%) in the screening group and 5394 of 30 613 (17.6%) in the no screening group. Within 12 hours of the alert, patients in the screening group were more likely to have serum lactate tested (adjusted relative risk [aRR], 1.30; 95% CI, 1.16-1.45) and intravenous fluid ordered (aRR, 2.17; 95% CI, 1.92-2.46) compared with those in the no screening group. In the primary outcome analysis, electronic screening resulted in lower 90-day in-hospital mortality (aRR, 0.85; 95% CI, 0.77-0.93; P < .001). Screening reduced vasopressor therapy and multidrug-resistant organisms but increased code blue activation, incident kidney replacement therapy, and C difficile.

Conclusions and Relevance  Among hospitalized ward patients, electronic sepsis screening compared with no screening resulted in significantly lower in-hospital 90-day mortality.

Trial Registration  ClinicalTrials.gov Identifier: NCT04078594

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