Original Investigation  Neurology Diagnostic Accuracy of Plasma Biomarkers for Mild Traumatic Brain Injury in Older Adults Gershon Spitz, Jake Mitchell, Beatrice Duarte Martins, et al JAMA Netw Open 2026;9;(5):e2615678. doi:10.1001/jamanetworkopen.2026.15678 Key Points Question  What is the diagnostic accuracy of plasma biomarkers for mild traumatic brain injury (mTBI) in older adults, and can these bioma...

JAMA Clinical Guidelines Synopsis  Perioperative Cardiovascular Medication Management for Noncardiac Surgery David E. Winchester, Jeet J. Mehta, Jason T. Alexander JAMA 2026;335;(19):1717-1718. doi:10.1001/jama.2026.0067 Guideline title 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery Release date September 24, 2024 Prior version 2014 Developers and funding sources&...

WHO guidelines for the clinical management of filovirus disease: Executive summary Key recommendations Systematic patient monitoring should be established for patients with suspected or confirmed filovirus disease, using structured and documented clinical assessment at regular intervals, with frequency adapted to patient condition (Good practice statement). WHO recommends that for patients with suspected or confirmed filovirus disease, systematic laboratory moni...

JAMA Clinical Guidelines Synopsis  Management of Acute Coronary Syndrome Adam S. Vohra, Jason T. Alexander, Atman P. Shah JAMA Published Online: March 30, 2026 doi: 10.1001/jama.2026.1214 Guideline title ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndrome Release date February 27, 2025 Prior versions 2013 and 2014 Developers American College of Cardiology (ACC), American Heart Associati...

CONFERENCE REPORTS AND EXPERT PANEL Clinical criteria for the definition of refractory septic shock: a joint Delphi consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) Leone, M., Myatra, S.N., Dugar, S. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08344-2 Abstract Objective A definition of refractory septic shock is necessary to guide diagnosis, management, prognostic...

JAMA Clinical Guidelines Synopsis  Caring for Pediatric Patients With Sepsis Tracy A. Lieu, Jason T. Alexander, Christopher W. Seymour JAMA Published Online: March 26, 2026 doi: 10.1001/jama.2026.3800 Guideline title Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026 Release date March 23, 2026 Prior version 2020 Developer and funding source Society of Critical Care ...

JAMA Clinical Guidelines Synopsis  Caring for Adult Patients With Sepsis Christopher W. Seymour, Kirsten Bibbins-Domingo, Jason T. Alexander JAMA Published Online: March 26, 2026 doi: 10.1001/jama.2026.3793 Guideline title Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026 Release date March 23, 2026 Developer European Society of Intensive Care Medicine (ESICM) and Society of Critical Care...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines on Caring for Older Adults in the ICU Ferrante, Lauren E.; Chaudhuri, Dipayan; Laiya Carayannopoulos, Kallirroi; et al Critical Care Medicine March 20, 2026 DOI: 10.1097/CCM.0000000000007085 Rationale:  Older adults (those 65 years old or greater) compose a substantial proportion of the ICU population. As older adults with critical illness possess unique factors and considerations relevant...

SPECIAL ARTICLE Society of Critical Care Medicine Guidelines for the Administration of Neuromuscular Blockade in Adults With Acute Respiratory Distress Syndrome Erstad, Brian L; Cobas, Miguel A; Qadir, Nida; et al Critical Care Medicine 54(3):p 634-643, March 2026. DOI: 10.1097/CCM.0000000000007002 Rationale:  Neuromuscular blocking agents (NMBAs) show potential benefits on mortality and other complications of acute respiratory distress syndrome (AR...

Practice Rapid Recommendations Summary of WHO clinical practice guidelines for influenza Per Olav Vandvik, Arnav Agarwal, Jamie Rylance, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-087397 (Published 27 February 2026)Cite this as: BMJ 2026;392:e087397 Abstract About this guideline This BMJ Rapid Recommendation is a summary of a World Health Organization guideline published 12...