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Immunotherapy effects on sepsis A randomised controlled multicentre trial assessed for the first time the safety and pharmacokinetics of an antiprogrammed cell death-ligand 1 (anti–PD-L1) immune checkpoint inhibitor (BMS-936559; Bristol-Myers Squibb, Princeton, NJ) and its effect on immune biomarkers in participants with sepsis-associated immunosuppression. Results show that BMS-936559 was well tolerated, with no evidence of drug-induced hypercytokinaemia or cyt...
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Pessimism in providing critical care for elderly patients A recent study conducted in France investigated the association of age with long-term mortality after discharge from the ICU. Another subset of this discussion relates to the critically ill elderly patients who have higher mortality compared to younger patients as well as longer lengths of stay in the ICU prior to death.  There has been a great deal of discussion on how a disproportionate amount of health...
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ORIGINAL ARTICLE C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations Christopher C. Butler, David Gillespie, Patrick White, et al N Engl J Med 2019; 381:111-120DOI: 10.1056/NEJMoa1803185 Abstract BACKGROUND 背景 Point-of-care testing of C-reactive protein (CRP) may be a way to reduce unnecessary use of antibiotics without harming patients who have acute exacerbations of chronic obstructive pulmonary disease (COPD). ...
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Effect of adhesive tape versus endotracheal tube fastener in critically ill adults The securement method of endotracheal tubes should ideally prevent dislodgement and minimise complications. Endotracheal tube fastener can reduce complications among critically ill patients who are undergoing endotracheal intubation.  You might also like:UK study: extubating ventilated patients on vasoactive infusions 'safe' A study was conducted with critically ill adults who ...
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ARTICLES|ONLINE FIRST Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study The Pneumonia Etiology Research for Child Health (PERCH) Study Group Lancet Published: June 27, 2019 DOI:https://doi.org/10.1016/S0140-6736(19)30721-4 Summary Background 背景 Pneumonia is the leading cause of death among children younger than 5 years. In this study, we estimated c...
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Resuscitation in septic shock: is less better? On Day 2 of the Euroanaesthesia Congress 2019 (#EA19), there was a session on Resuscitation in septic shock: is less better? Three key speakers Gernot Marx (Aachen, Germany), Claude Martin (Marseille, France) and Jean-Louis Vincent (Brussels, Belgium), spoke about less fluid, less vasopressors and less inotropes in septic shock. The central message of this session was simple: less is more in sepsis.  The session was...
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ARTICLES|ONLINE FIRST The burden of Legionnaires' disease in New Zealand (LegiNZ): a national surveillance study Patricia C Priest, Sandy Slow, Stephen T Chambers, et al Lancet Published:June 10, 2019 DOI:https://doi.org/10.1016/S1473-3099(19)30113-6 Summary Background 背景 Legionnaires' disease is under-diagnosed because of inconsistent use of diagnostic tests and uncertainty about whom to test. We assessed the increase in case detection following large...
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Acute pain in the ICU: management beyond the usual therapeutic strategies At this year’s Euroanaesthesia 2019 in Vienna, Austria, Prof. Caterina Aurilio (Naples, Italy), talked about acute pain management in the ICU. She started her presentation with the definition of pain as outlined by the International Association for the Study of Pain (IASP). Pain is an "unnecessary sensory and emotional experience associated with actual or potential tissue damage, or desc...
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ARTICLES| VOLUME 19, ISSUE 6, P601-610, JUNE 01, 2019 Effect of carbapenem resistance on outcomes of bloodstream infection caused by Enterobacteriaceae in low-income and middle-income countries (PANORAMA): a multinational prospective cohort study Andrew J Stewardson, Kalisvar Marimuthu, Sharmila Sengupta, et al Lancet Infect Dis 2019; 19: 601-610 Summary Background 背景 Low-income and middle-income countries (LMICs) are under-represented i...
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ONLINE FIRST THIS WEEK(FREE ACCESS) Review ~ Assoun S. - Molecular targeted therapy-related life-threatening toxicity in patients with malignancies. A systematic review of published cases Original ~ Haines K. J. - Key mechanisms by which post-ICU activities can improve in-ICU care: results of the international THRIVE collaboratives Imaging in Intensive Care Medicine ~ Salden R. L. T. N. - Camel shape in transpulmonary thermodilution monitoringWhat's new in intensive ca...
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