Prehospital Cricothyrotomy in Emergency Airway Management In ICU Thu, 3 Jul 2025 Cricothyrotomy, an emergency airway procedure through the cricoid membrane, has been used in emergency and prehospital settings since the 1980s. Due to its rarity and high risk of error, it is considered a high-risk, low-occurrence procedure. Understanding when EMS performs cricothyrotomy is crucial to improving training and prehospital airway care. Several studies have...

A consensus blood transcriptomic framework for sepsis Scicluna, B.P., Cano-Gamez, K., Burnham, K.L. et al. Nat Med (2025). https://doi.org/10.1038/s41591-025-03964-5 Abstract Sepsis is a life-threatening condition driven by a maladaptive host response to infection. To establish a standardized blood transcriptomic subtype model, we aggregated blood transcriptomics data from two major sepsis cohorts: the Molecular Diagnosis and Risk Stratification of Sepsis (MAR...

Original Investigation  Public Health A Hybrid Chatbot to Promote Pneumococcal Vaccination Among Older Adults: A Randomized Clinical Trial Zixin Wang, Siyu Chen, Josiah Poon, et al JAMA Netw Open 2025;8;(10):e2535813. doi:10.1001/jamanetworkopen.2025.35813 Key Points Question  Can a hybrid chatbot combining a rule-based component delivering co-designed tailored interventions and an artificial intelligence...

Article Heterogeneity and predictors of the effects of AI assistance on radiologists Yu, F., Moehring, A., Banerjee, O. et al. Nat Med 30, 837–849 (2024) https://doi.org/10.1038/s41591-024-02850-w Abstract The integration of artificial intelligence (AI) in medical image interpretation requires effective collaboration between clinicians and AI algorithms. Although previous studies demonstrated the potential of AI assistance in improving overall clinician ...

Environmental Sustainability in Intensive Care Medicine In ICU Thu, 3 Jul 2025 The climate crisis requires decarbonisation across all major emission sectors, including healthcare, which contributes 4–5% of global emissions due to its complex supply chains, high energy use, and waste. Ninety-three countries have committed under a WHO initiative to develop environmentally responsible health systems. Addressing healthcare emissions needs a multi-faceted e...

Original Investigation  Helicobacter pylori Screening After Acute Myocardial Infarction: The Cluster Randomized Crossover HELP-MI SWEDEHEART Trial Robin Hofmann, Stefan James, Martin O. Sundqvist, et al JAMA 2025;334;(13):1160-1169. doi:10.1001/jama.2025.15047 Key Points Question  Does routine Helicobacter pylori screening with urea breath test of patients with myocardial infarction reduce upper gastrointestinal bleeding events? ...

Original Investigation  Critical Care Medicine Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation Jean-Eric Tarride, Gord Blackhouse, Bram Rochwerg, et al JAMA Netw Open 2025;8;(9):e2529399. doi:10.1001/jamanetworkopen.2025.29399 Key Points Question  What is the cost-effectiveness of in-bed cycling plus usual physiotherapy compared with usual physi...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Original Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock: a post hoc analysis of a randomized controlled trialPirracchio, R., Fong, N. & Legrand, M. OPEN ACCESS ~ Original Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 casesMonneret, G., Lafon, T., Gossez, M. et al. Acute respiratory distre...

Original Investigation  Critical Care Medicine Early Blood Pressure Targets in Acute Spinal Cord Injury: A Randomized Clinical Trial Ruba Sajdeya, N. David Yanez, Michael Kampp, et al JAMA Netw Open 2025;8;(9):e2525364. doi:10.1001/jamanetworkopen.2025.25364 Key Points Question  Compared with conventional blood pressure, does early blood pressure augmentation improve long-term neurologic outcomes in acute spinal cord injury? Findings&nb...

Reduced Plasma Volume Response to Crystalloid Fluid in Goal‑Directed Fluid Therapy In ICU Wed, 25 Jun 2025 Anaesthetists use fluids and drugs during surgery to maintain adequate tissue perfusion pressure and oxygenation. Goal-directed therapy (GDT) is a strategy aimed at optimising cardiovascular function and organ perfusion during the perioperative period by closely monitoring haemodynamic parameters such as cardiac output (CO), blood pressure, oxygen...