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ARTICLES| VOLUME 399, ISSUE 10321, P237-248, JANUARY 15, 2022 Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial Scott A Halperin, Lingyun Ye, Donna MacKinnon-Cameron, et al Lancet 2022; 399: 237-248 Summary Background ...
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ICU Management & Practice, Volume 21 - Issue 5, 2021 Management of Acute Arrhythmias in Patients With Cardiac Dysfunction - Update of ESC Guidelines In 2020, the ultra-short acting beta-blocker landiolol was first included in the ESC guidelines with a class I recommendation. The recommendations were based on study results demonstrating the rapid response, efficacy, and safety of this drug. At a recent symposium, during 2021 Heart Failure World Congress, car...
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Original Investigation December 20, 2021 Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial Ting Li, Jun Li, Liyong Yuan, et al JAMA. Published online December 20, 2021. doi:10.1001/jama.2021.22647 Abstract Importance  In adults undergoing hip fracture surgery, regional anesthesia may reduce postoperative delirium, but there is ...
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ICU Management & Practice, Volume 21 - Issue 5, 2021 Microbiome and Pneumonia in Children A significant research gap exists in the field of the lung microbiome and pneumonia development in paediatric population. Its study may improve nosocomial pneumonia prevention and help to achieve zero pneumonia rates. Most frequent hospital acquired infections (HAI) in Paediatric Intensive Care Units (PICU), are ventilator associated pneumonia (VAP), catheter-relate...
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COMMENT|ONLINE FIRST Mixing mRNA, adenoviral, and spike-adjuvant vaccines for protection against COVID-19 Christopher D Richardson Lancet Published:December 06, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)02757-4 Supply and availability issues for government-approved vaccines, together with worries about rare side-effects (such as thrombotic thrombocytopenia), have necessitated the switch to heterologous COVID-19 vaccination schedules—an approach commonl...
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Respiratory Subphenotypes of COVID-19-Related ARDS Patients with COVID-19 related ARDS present with distinct respiratory subphenotypes. But most phenotyping schema is limited by sample size, disregard for temporal dynamics and insufficient validation. In the PRoVENT-COVID study, researchers aimed to identify respiratory subphenotypes of COVID-19-related ARDS. This was an investigator-initiated observational cohort study at 22 ICUs in the Netherlands. COVID-19 pa...
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ARTICLES|ONLINE FIRST Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial Arabella S V Stuart, Robert H Shaw, Xinxue Liu, et al Lancet Published:December 06, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)02718-5 Summary Background Given the importance of flexible use of di...
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ICU Management & Practice, Volume 21 - Issue 5, 2021 The Role of the Microbiome and Nutritional Therapy in Critical COVID-19 Dysbiosis has been closely related to inflammation and severe-to-critical COVID-19, a reason why nutritional therapy could be important in the prevention and management of critical disease. Introduction Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease (COVID-19), inv...
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Feature BMJ Investigation Covid-19: Researcher blows the whistle on data integrity issues in Pfizer’s vaccine trial Paul D Thacker BMJ 2021; 375 doi: https://doi.org/10.1136/bmj.n2635 (Published 02 November 2021)Cite this as: BMJ 2021;375:n2635 Revelations of poor practices at a contract research company helping to carry out Pfizer’s pivotal covid-19 vaccine trial raise questions about data integrity and regulatory oversight. Paul D Thacker repo...
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ICU Management & Practice, Volume 21 - Issue 5, 2021 The Intestinal Microbiome in Critical Illness Critical illness alters the intestinal microbiome, resulting in a loss of microbial diversity and induction of a pathobiome. Manipulating the intestinal microbiome offers a potential treatment approach in ICU patients. The intestinal microbiome is comprised of diverse, robust microbial communities within the intestine, modified by the host’s interaction wit...
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