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Venous Doppler to Predict Adverse Kidney Events In patients admitted to the ICU following surgery, trauma or septic shock, fluid boluses are often used to increase cardiac output and blood pressure. However, clinical evidence shows that excess fluid administration could be detrimental for patients and could lead to increased rates of acute kidney injury (AKI), prolonged days of mechanical ventilation and death. There are currently no established ultrasound measures of ...
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ORIGINAL ARTICLE SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19 Peter Chen, Ajay Nirula, Barry Heller, et al N Engl J Med October 28, 2020DOI: 10.1056/NEJMoa2029849 Abstract BACKGROUND Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-threatening. Virus-neutralizing monoclonal antibodies are predicted to reduce viral lo...
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Use of Non-Invasive Ventilation in Critically Ill Older Adults In seriously ill older adults or those near the end of life, acute respiratory failure is a common cause of hospitalisation. These hospitalisations are generally complicated by distressful respiratory symptoms and transitions that require the use of high-intensity, high-risk interventions, including invasive mechanical ventilation (IMV) and non-invasive ventilation (NIV).  Trends in both invasive an...
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ORIGINAL ARTICLE A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia Ventura A. Simonovich, Leandro D. Burgos Pratx, Paula Scibona, et al N Engl J Med November 24, 2020DOI: 10.1056/NEJMoa2031304 Abstract BACKGROUND Convalescent plasma is frequently administered to patients with Covid-19 and has been reported, largely on the basis of observational data, to improve clinical outcomes. Minimal data are available from adequately powered ran...
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ONLINE FIRST THIS WEEK(FREE ACCESS)  What's New In Intensive Care ~ De Waele JJ et al. - Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90sLetter ~ Schaefer MS et al. - Comparison of mechanical power estimations in mechanically ventilated patients with ARDS: a secondary data analysis from the EPVent studyEditorial ~ Shaw JA et al. - Five things every clinician should know about AI ...
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Research Letter October 12, 2020 Excess Deaths From COVID-19 and Other Causes, March-July 2020 Steven H. Woolf, Derek A. Chapman, Roy T. Sabo, et al JAMA Published online October 12, 2020. doi:10.1001/jama.2020.19545 Previous studies of excess deaths (the gap between observed and expected deaths) during the coronavirus disease 2019 (COVID-19) pandemic found that publicly reported COVID-19 deaths underestimated the full death toll, which includes...
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ICU Management & Practice, Volume 20 - Issue 2, 2020 Sleep Deprivation and Fatigue Management in the Intensive Care Unit The impact of sleep deprivation and fatigue on patients and staff in the intensive care unit and how improved sleep, reduced noise disturbances, and more organised shifts could be beneficial for both patients and clinicians. The World Health Organization (WHO) recommends that average daily sound levels in patient care areas should be a...
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A living WHO guideline on drugs for covid-19 Bram Rochwerg, Thomas Agoritsas, François Lamontagne, et al BMJ 2020;370:m3379 doi: https://doi.org/10.1136/bmj.m3379 (Published 04 September 2020) Abstract Clinical question What is the role of drug interventions in the treatment of patients with covid-19? New recommendation The latest version of this WHO living guidance focuses on remdesivir, following the 15 October 2020 preprint...
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ICU Management & Practice, Volume 20 - Issue 3, 2020 Advances in Sepsis Research – New Tools Against One of the Oldest Diseases? Sepsis and septic shock are the leading causes of death in the ICU. With an estimated mortality rate of 40-60%, septic shock is in the focus of adult critical care medicine. It is broadly accepted that intervention in the very early phase of sepsis before the complex inflammatory host response is initiated should be one major area...
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ARTICLES| VOLUME 20, ISSUE 10, P1151-1160, OCTOBER 01, 2020 Effectiveness of isolation, testing, contact tracing, and physical distancing on reducing transmission of SARS-CoV-2 in different settings: a mathematical modelling study Adam J Kucharski, Petra Klepac, Andrew J K Conlan, et al Lancet Infect Dis 2020; 20: 1151-1160 Summary 摘要 Background 背景 The isolation of symptomatic cases and tracing of contacts has been used as an early COVID-19 containme...
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