Original Investigation  Critical Care Medicine Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial Anatole Harrois, Romain Jouffroy, Soufia Ayed, et al JAMA Netw Open 2025;8;(12):e2548201. doi:10.1001/jamanetworkopen.2025.48201 Key Points Question  What are the effects of awake prone positioning on the incidence of intubation and/or death in nonintubated pati...

Immune Dysregulation Framework for Sepsis and Critical Illnesses In Sepsis Thu, 2 Oct 2025 When a critically ill patient arrives in the emergency department, physicians must make rapid, high-stakes decisions related to infection and whether that infection is bacterial or viral. There are decisions related to whether the patient needs immediate treatment, and whether they can recover safely at home or must be admitted.  Even once an infection is...

Original Investigation  Implications of Changing Institutions for Promotion in Academic Surgery Isabelle M. C. Tan, Haley Harris, Yuqing Qiu, et al JAMA Surg Published Online: December 10, 2025 doi: 10.1001/jamasurg.2025.5490 Key Points Question  Does changing institutions impact academic promotion pathways for academic surgeons? Findings  In this cohort study of 6321 surgical facul...

Editorial  Reconsidering Oxygen at Birth for Preterm Infants: Lessons From TORPIDO 30/60 Alyssa R. Thomas, Elizabeth E. Foglia JAMA Published Online: December 10, 2025 doi: 10.1001/jama.2025.23127 At birth, newborns must transition from the low-oxygen environment of the womb to postnatal normoxemia. Most preterm newborns require supplemental oxygen to support this process. Yet, active debate remains about the optimal starting fraction of inspired oxyge...

Noncommunicable Diseases as a Grow Catalyst  In EXEC Sun, 21 Sep 2025 Noncommunicable diseases are reshaping population health and national economies as ageing accelerates and prevention efforts lag. The scale is already large and, without decisive action, forecasts point to heavier human and economic costs by 2050. Yet the same evidence base that describes the problem also maps out a route to measurable gains in longevity, healthy life and produc...

Research Letter  Occupational Health Disinfecting Wipes and Barrier Resistance of Protective Clothing F. Selcen Kilinc-Balci, Patrick L. Yorio, Zafer Kahveci, et al JAMA Netw Open 2025;8;(10):e2539307. doi:10.1001/jamanetworkopen.2025.39307 Introduction Protective clothing (PC), including gowns and coveralls, is crucial personal protective equipment (PPE) for health care and laboratory workers (HCLWs) to prevent transmission of contaminated fluids. ...

Original Investigation  Targeted Oxygen for Initial Resuscitation of Preterm Infants: The TORPIDO 30/60 Randomized Clinical Trial Ju Lee Oei, Adrienne Kirby, Javeed Travadi, et al JAMA Published Online: December 10, 2025 doi: 10.1001/jama.2025.23327 Key Points Question  Does initiating resuscitation of extremely preterm newborns with a higher level of fraction of inspired oxygen (Fio2; 0.6) redu...

Original Investigation  Cardiology Light Exposure at Night and Cardiovascular Disease Incidence Daniel P. Windred, Angus C. Burns, Martin K. Rutter, et al JAMA Netw Open 2025;8;(10):e2539031. doi:10.1001/jamanetworkopen.2025.39031 Key Points Question  Is personal light exposure at night associated with cardiovascular disease incidence? Findings  In this cohort study of 88 905 adults aged older than 40 years, exposure to bright...

Gender Representation Trends and Senior Authorships in High Impact Critical Care Journals In ICU Fri, 26 Sep 2025 Gender disparities remain entrenched in medical academia, particularly in authorship positions linked to seniority and prestige. Women are underrepresented as first and senior authors, transition more slowly to senior authorship, and face greater gaps in high-impact journals and randomised controlled trials. Wealthy countries often show few...

Articles Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis Ioannis Gallos, Caitlin R Williams, Malcolm J Price, et al Lancet 2025; 406: 1969-1982 https://doi.org/10.1016/S0140-6736(25)01639-3 Summary Background Postpartum haemorrhage (excessive bleeding after birth) is a leading cause of maternal mortality and morbidity worldwide. However...