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Risk Factors for ARDS in Mechanically Ventilated Adults Acute respiratory distress syndrome (ARDS) is an inflammatory process that could lead to diffuse oedema and hypoxaemic respiratory failure. It is also characterised by increased pulmonary vascular permeability, increased lung weight, and loss of aerated lung. In low and middle-income countries, ARDS mortality ranges from 26 to 58%.  A large majority of patients require mechanical ventilation with positive press...
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Editorial | December 30, 2019 Decreasing Staphylococcus aureus in the Neonatal Intensive Care Unit by Decolonizing Parents Philip Zachariah, Lisa Saiman JAMA. Published online December 30, 2019. doi:https://doi.org/10.1001/jama.2019.20784 Infants hospitalized in the neonatal intensive care unit (NICU) continue to pose challenges for infection prevention and control.1 Immunologic immaturity in addition to iatrogenic risk factors, such as high rates of...
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Hydrocortisone Versus Placebo in Patients with Septic Shock Septic shock is a serious illness that is associated with high morbidity and mortality. A significant number of patients who develop septic shock also have a number of comorbidities that further worsens the prognosis. Over the years, many studies have been published on the benefits of corticosteroids in patients with septic shock. Most of these studies have not shown any significant benefit. The few studies th...
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Preliminary Communication | December 30, 2019 Effect of Treating Parents Colonized With Staphylococcus aureus on Transmission to Neonates in the Intensive Care Unit: A Randomized Clinical Trial Aaron M. Milstone, Annie Voskertchian, Danielle W. Koontz, et al JAMA. Published online December 30, 2019. doi:https://doi.org/10.1001/jama.2019.20785 Abstract Importance 背景 Staphylococcus aureus is a l...
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Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study Summary Background 背景 Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the global burden of sepsis are limited. As a syndrome caused by underlying infection, sepsis is not part of standard Global Burden of Diseases, Injuries, and Risk Fa...
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SPOTLIGHT|ONLINE FIRST Organising international research in critical care medicine: current challenges and potential solutions Jan J De Waele, Dylan W de Lange Lancet Respir Med Published: December 17, 2019 DOI:https://doi.org/10.1016/S2213-2600(19)30475-8 During the first years of intensive care medicine, many of its treatments were introduced because they were thought to be beneficial to patients, despite there being a lack of evidence from high-quality rese...
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ICU Management & Practice, Volume 19 - Issue 3, 2019 The Metabolic Phenotype of Skeletal Muscle During Early Critical Illness The Muscle UK Critical Care program was set up 10 years ago and focused on the association between muscle and skeletal muscle wasting to weakness to clinical outcome. There are a total of five pivotal trials, including Bernhard Jonghe et al.1 and Herridge M.2 that looked at skeletal muscle weakness and its impact on patients. In the ...
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Research Christmas 2019: Let it Be Q fever—the superstition of avoiding the word “quiet” as a coping mechanism: randomised controlled non-inferiority trial Charlotte R Brookfield, Patrick P J Phillips, Robert J Shorten BMJ 2019; 367: l6446 doi: https://doi.org/10.1136/bmj.l6446 (Published 18 December 2019) Objective 目的 To determine the validity of the superstition that utterance of the word “quiet” in a clinical setting increases workload. 确定在...
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Research Christmas 2019: Sweet Little Lies The SSSPIN study—spin in studies of spin: meta-research analysis Lisa Bero, Kellia Chiu, Quinn Grundy BMJ 2019; 367: l6202 doi: https://doi.org/10.1136/bmj.l6202 (Published 18 December 2019) Objectives 目的 To identify and calculate the prevalence of spin in studies of spin. 确定并计算有关倾向性陈述研究中倾向性陈述的比例 Design 试验设计 Meta-research analysis (research on research). meta研究分析(对...
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ICU Management & Practice, Volume 19 - Issue 3, 2019 DIVINE Nutritional Management in ICU The following is an overview of the DIVINE trial (Dietary Management of Glucose Variabilty in the ICU) as well as a quick summary of the role of glucose control and outcomes in critically ill patients. The DIVINE study was funded by Nestlé. Clinical studies show that goal nutrition may not result in the best outcomes. Available data suggest that protein may be more ...
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