CLINICAL DECISIONS Blood-Pressure Targets in Hypertension Management Christos P. Kotanidis, Paul K. Whelton, Clinton B. Wright N Engl J Med 2026;394:1026-1029 DOI: 10.1056/NEJMclde2505268 CASE VIGNETTE A Man with Hypertension Christos P. Kotanidis, M.D., D.Phil. A 75-year-old man comes to your primary care practice for a routine follow-up appointment. His medical history is notable for hypertension that is managed with...

CLINICAL DECISIONS Blood-Pressure Targets in Hypertension Management Christos P. Kotanidis, Paul K. Whelton, Clinton B. Wright N Engl J Med 2026;394:1026-1029 DOI: 10.1056/NEJMclde2505268 CASE VIGNETTE A Man with Hypertension Christos P. Kotanidis, M.D., D.Phil. A 75-year-old man comes to your primary care practice for a routine follow-up appointment. His medical history is notable for hypertension that is managed with ramipril and amlodipine. He i...

JOURNAL ARTICLE A 46-Year-Old With Persistent Altered Mental Status and Respiratory Failure Ann F Yang, Aesha Jobanputra, Thomas J Kirn, et al  Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 159–161, https://doi.org/10.1093/cid/ciaf439 Question: A 46-year-old undomiciled man with a past medical history of alcohol use disorder was found unresponsive and admitted for evaluation of altered mental status. He immigra...

JOURNAL ARTICLE A 46-Year-Old With Persistent Altered Mental Status and Respiratory Failure Ann F Yang, Aesha Jobanputra, Thomas J Kirn, et al  Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages 159–161, https://doi.org/10.1093/cid/ciaf439 Question: A 46-year-old undomiciled man with a past medical history of alcohol use disorder was found unresponsive and admitted for evaluation of altered mental status. He immigrated from Mexico in 1...

JAMA Clinical Challenge  October 30, 2023 Coin-Shaped Opacities in the Stomach Neil Shadbeh Evans, Paul Aronowitz, Timothy E. Albertson JAMA. 2023;330(20):2016-2017. doi:10.1001/jama.2023.19032 Case A50-year-old man with end-stage kidney disease receiving hemodialysis was admitted to the hospital for treatment of calciphylaxis and foot cellulitis. His home medications included sevelamer and hydrocodone-acetaminophen (10...

JAMA Clinical Challenge  October 30, 2023 Coin-Shaped Opacities in the Stomach Neil Shadbeh Evans, Paul Aronowitz, Timothy E. Albertson JAMA. 2023;330(20):2016-2017. doi:10.1001/jama.2023.19032 Case A50-year-old man with end-stage kidney disease receiving hemodialysis was admitted to the hospital for treatment of calciphylaxis and foot cellulitis. His home medications included sevelamer and hydrocodone-acetaminophen (10...

JAMA Clinical Challenge  October 6, 2023 Peripheral Blasts in a Patient Receiving Chemotherapy Sabin Kshattry, Terri L. Parker, Scott F. Huntington JAMA. 2023;330(16):1581-1582. doi:10.1001/jama.2023.17117 Case An 80-year-old man with stage II bladder carcinoma (T2NXM0) and atrial fibrillation treated with apixaban presented to the emergency department with 1 week of fatigue and 2 days of dyspnea on exertion. One week p...

JAMA Clinical Challenge  October 6, 2023 Peripheral Blasts in a Patient Receiving Chemotherapy Sabin Kshattry, Terri L. Parker, Scott F. Huntington JAMA. 2023;330(16):1581-1582. doi:10.1001/jama.2023.17117 Case An 80-year-old man with stage II bladder carcinoma (T2NXM0) and atrial fibrillation treated with apixaban presented to the emergency department with 1 week of fatigue and 2 days of dyspnea on exertion. One week prior to presentation, he recei...

JAMA Diagnostic Test Interpretation  August 21, 2023 Multistep Testing Algorithms for Clostridioides difficile Infection Maribeth R. Nicholson, Curtis J. Donskey JAMA. Published online August 21, 2023. doi:10.1001/jama.2023.15875 Case A10-year-old female with spina bifida and neurogenic bowel was hospitalized for abdominal pain, dehydration, and more than 20 episodes of watery diarrhea per day. Her symptoms be...

Teachable Moment  August 14, 2023 Mild Transaminase Elevation With Rapid Diagnostic Escalation: A Teachable Moment Priyal Gandhi, Niloofar Latifi JAMA Intern Med. Published online August 14, 2023. doi:10.1001/jamainternmed.2023.3884 Story From the Front Lines A33-year-old woman with well-controlled hypertension and body mass index of 21 (calculated as weight in kilograms divided by height in meters squared) presented to primary care for fo...