Human-Centred AI in Critical Care  In ICU Thu, 11 Dec 2025 A recent review advocates for a fundamental shift in how artificial intelligence is integrated into intensive care units, moving away from a narrow focus on model development towards comprehensive human-centred AI system design. The discussion is based on the World Health Organization’s 2021 ethical framework, which establishes six core principles for AI in healthcare: protecting human aut...

Articles Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial Miriam M Treggiari, Emily S Sharp, Tetsu Ohnuma, et al Lancet Respir Med 2026; 14: 141-150 https://doi.org/10.1016/S2213-2600(25)00294-2 Summary Background Endotracheal tubes with subglottic ports and a polyurethane cuff are recommended for reducing microaspi...

ImmunoSep: Precision Immunotherapy to Improve Sepsis Outcomes  In Sepsis Thu, 11 Dec 2025 Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Many immunotherapy trials have failed because sepsis presents with highly variable immune states, ranging from excessive inflammation to profound immunosuppression. A precision-medicine approach, guided by rapid biomarker-based immune profiling, may therefore be need...

Articles Accounting for non-adherence to assigned antibiotic treatment duration for bloodstream infection (BALANCE): a post-hoc analysis of a randomised clinical trial Sean W X Ong, Ruxandra Pinto, Robert K Mahar, et al Lancet Infect Dis 2026; 26: 250-259 https://doi.org/10.1016/S1473-3099(25)00592-4 Summary Background The BALANCE trial (NCT03005145) showed non-inferiority of 7-day versus 14-day antibiotic duration for treatment of patients with non-S...

Practice Rapid Recommendations Summary of WHO clinical practice guidelines for influenza Per Olav Vandvik, Arnav Agarwal, Jamie Rylance, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-087397 (Published 27 February 2026)Cite this as: BMJ 2026;392:e087397 Abstract About this guideline This BMJ Rapid Recommendation is a summary of a World Health Organization guideline published 12...

Research Machine learning based screening of potential paper mill publications in cancer research: methodological and cross sectional study Baptiste Scancar, Jennifer A Byrne, David Causeur, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-087581 (Published 30 January 2026)Cite this as: BMJ 2026;392:e087581 Abstract Objectives To train and validate a machine learning model to distinguish paper mill publ...

Metabolic Shifts Precede Sepsis Organ Dysfunction In Sepsis Wed, 6 Aug 2025 Sepsis is a severe condition causing widespread organ damage and failure, affecting multiple systems like cardiovascular, immune, and metabolic. Understanding of the mechanisms remains limited, hindering targeted treatments. Metabolism, especially mitochondrial dysfunction, has emerged as a key factor in sepsis progression. Biomarkers like lactate are commonly used, though t...

Original Investigation  Health Policy Hospital Nurse Understaffing and Patient Mortality, Readmission, and Length of Stay Noriko Morioka, Mutsuko Moriwaki, Atsushi Miyawaki, et al JAMA Netw Open 2026;9;(2):e2558235. doi:10.1001/jamanetworkopen.2025.58235 Key Points Question  Is nurse understaffing during the day shift or evening and night shift, relative to typical ward staffing levels, associated with pa...

Original Investigation  Worldwide Radiation Dose in Coronary Artery Disease Diagnostic Imaging Andrew J. Einstein, Michelle C. Williams, Jonathan R. Weir-McCall, et al JAMA Published Online: February 25, 2026 doi: 10.1001/jama.2026.0703 Key Points Question  How does radiation dose from cardiac diagnostic testing vary worldwide? Findings  In this cross-sectional study in 101 countrie...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE What's New in Intensive Care Hyperoxaemia in acute brain injured patients: too much of a good thing?Sekhon, M.S., Robba, C. & Young, P.J.  PERIOPERATIVE CARE IN THE ICU OPEN ACCESS ~ Review Intraoperative blood pressure management in noncardiac surgery: a narrative review based on current evidenceJoosten, A., Chew, M.S., Futier, E. et al. PHYSIOLOGY IN CRITICAL ILLNESS What's New in Inten...