Articles Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group Lancet Available online 17 June 2026 https://doi.org/10.1016/S0140-6736(26)00761-0 Summary Background Previously considered rare, penicillin-suscept...

Original Investigation  Health Informatics A Community-Level Digital Health Readiness Index for the US Saif Khairat, John Geracitano, Zhaoqiang Zhou, et al JAMA Netw Open 2026;9;(6):e2619372. doi:10.1001/jamanetworkopen.2026.19372 Key Points Question  Can a census tract-level Digital Health Index (DHI), developed from public data, quantify community readiness for digital care beyond existing indices? F...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES What’s New in Intensive Care Acute respiratory distress syndrome in patients with obesityDe Jong, A., Berra, L. & Hernández, G. Imaging in Intensive Care Medicine A misleading acute respiratory failure: when infection is not where you expect itPequignot, B., Barraud, D., Stephan, C. et al. Black hole signHayano, S., Tani, N., Toyama, Y. et al. Correspondence Rethinking patient–ventilator asynchronies: ...

Original Investigation  Infectious Diseases Preferences for Infection Prevention in Hospital-Acquired Infections Shalini Elangovan, Sameera Senanayake, Indumathi Venkatachalam, et al JAMA Netw Open 2026;9;(4):e267432. doi:10.1001/jamanetworkopen.2026.7432 Key Points Question  What factors most affect health care professionals’ decisions when selecting infection prevention and control practices for hospita...

Editorial  Prone Positioning in Viral Bronchiolitis—Back to the Back? Joseph G. Kohne, Susan R. Conway, Steven L. Shein JAMA Published Online: June 17, 2026 doi: 10.1001/jama.2026.11742 Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care.1 Despite the prevalence of this condition and its impact on children, families, and health systems, evi...

Original Investigation  High-Accuracy Performance of a Simplified Binary Triage System in Military Trauma Daniel Gelman, Ram Gelman, Inbal Dym, et al JAMA Surg Published Online: June 17, 2026 doi: 10.1001/jamasurg.2026.2083 Key Points Question  How accurately does a simplified judgment-based binary field triage system identify severely injured trauma casualties during combat operations? Findi...

Stepwise Clinical and Diagnostic Strategy for Coma In ICU Thu, 14 May 2026 A narrative review presents a structured, physiology-based diagnostic strategy for patients with coma of unknown origin. Coma is defined as a state of unarousable unresponsiveness characterised by the complete absence of both arousal and awareness. It represents one of the most urgent and diagnostically challenging conditions in acute care, particularly when there is no obvious ...

Original Investigation  Caring for the Critically Ill Patient Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial Florent Baudin, Robin Pouyau, Fabien Subtil, et al JAMA Published Online: June 17, 2026 doi: 10.1001/jama.2026.11078 Key Points Question  Does prone positioning reduce escalation of respiratory support in infants aged 6 months or younger...

ORIGINAL ARTICLE Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas Marco Ruella, Luca Paruzzo, Emeline R. Chong, et al N Engl J Med 2026;394:2440-2448 DOI: 10.1056/NEJMoa2518035 Abstract BACKGROUND Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is a standard treatment for relapsed or refractory B-cell non-Hodgkin lymphomas. Long-term results and curative potential remain uncertain. METHODS We evaluated long-term outcomes ...

Extracorporeal Life Support and Modification of Haemostasis In ICU Thu, 14 May 2026 The ELMOH (ExtracorporeaL life support and Modification Of Hemostasis) trial investigated how coagulation changes during the first 48 hours of extracorporeal membrane oxygenation (ECMO) and whether these changes differ between venovenous (VV) and venoarterial (VA) ECMO. ECMO is increasingly used in critically ill patients with severe respiratory or circulatory failure, ...