Original Investigation  May 8, 2024 Collaborative Care for Injured Older Adults: The Trauma Medical Home Randomized Clinical Trial Ben L. Zarzaur, Emma Holler, Damaris Ortiz, et al JAMA Surg. 2024;159(7):756-764. doi:10.1001/jamasurg.2024.1043 Key Points Question  Does a novel collaborative care intervention improve long-term outcomes in injured patients 50 years and older? Findings  In this randomized clinical trial including...

Viewpoint  May 20, 2024 Are Patients With Cancer Best Managed in a Clinical Trial? David I. Shalowitz, Franklin G. Miller JAMA. 2024;331(24):2077-2078. doi:10.1001/jama.2024.1235 Tremendous improvement in the care of patients with cancer is largely due to the proliferation of well-designed clinical trials leading to therapeutic advances. Additionally, the results of interventional cancer research have facilitated the development of robust, ev...

Cell-Based Immunotherapies for Sepsis In Sepsis Thu, 16 May 2024 Sepsis affects approximately 49 million people worldwide each year. To reduce the mortality rate and the global burden of sepsis, the World Health Organization has classified it as a priority research area. When combined with surgical trauma, anaesthetic drugs, and various invasive procedures, the impact intensifies, leading to further impairment of vita...

Original Investigation  Infectious Diseases July 2, 2024 Extended-Infusion β-Lactam Therapy, Mortality, and Subsequent Antibiotic Resistance Among Hospitalized Adults With Gram-Negative Bloodstream Infections Sara M. Karaba, Sara E. Cosgrove, Jae Hyoung Lee, et al JAMA Netw Open. 2024;7(7):e2418234. doi:10.1001/jamanetworkopen.2024.18234 Key Points Question  Is extended-infusion β-lactam (EI-...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalMeasuring the impact of maternal critical care admission on short- and longer-term maternal and birth outcomesMasterson J. A. et al OPEN ACCESS ~ OriginalIncidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trialsAntonucci E. et al EditorialMaternal critical careNelson-Piercy C., Luyckx V. A. and Krawczyk P. Redefining the paradigm: incentivizing the p...

Original Investigation  Emergency Medicine July 3, 2024 Termination of Resuscitation Rules and Survival Among Patients With Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis Michael A. Smyth, Imogen Gunson, Alison Coppola, et al JAMA Netw Open. 2024;7(7):e2420040. doi:10.1001/jamanetworkopen.2024.20040 Key Points Question  Can termination of resuscitation (TOR) rules accur...

Emergency Nurses Face Issues Related to Training, Staffing, Stress, Overflowing EDs In ICU Thu, 23 May 2024 Nurses working in emergency departments seek more training, stating that the high-pressure environment can negatively affect their decision-making. Researchers from the University of East Anglia (UEA) conducted the first-ever U.K. survey of triage nurses to explore their backgrounds, training, and decision-making processes. The study is p...

Original Investigation  Critical Care Medicine June 27, 2024 Trends in Empiric Broad-Spectrum Antibiotic Use for Suspected Community-Onset Sepsis in US Hospitals Chanu Rhee, Tom Chen, Sameer S. Kadri, et al JAMA Netw Open. 2024;7(6):e2418923. doi:10.1001/jamanetworkopen.2024.18923 Key Points Question  Is broad-spectrum antibiotic use for suspected community-onset sepsis changing over time? ...

Original Investigation  Pediatrics June 27, 2024 Early Antibiotic Exposure and Bronchopulmonary Dysplasia in Very Preterm Infants at Low Risk of Early-Onset Sepsis Wei Shi, Zheng Chen, Liping Shi, et al JAMA Netw Open. 2024;7(6):e2418831. doi:10.1001/jamanetworkopen.2024.18831 Key Points Question  Is early antibiotic exposure associated with higher risk of bronchopulmonary dysplasia (BPD) in ...

ONLINE FIRST (FREE ACCESS) TOPICAL COLLECTION "ARTIFICIAL INTELLIGENCE IN ICU" CorrespondenceAre we ready to harness AI and digital modelling for precision in PEEP settings?Collino F., Gattinoni L. and Camporota L. OPEN ACCESS ~ CorrespondenceWhy federated learning will do little to overcome the deeply embedded biases in clinical medicineSauer C. M. et al TOPICAL COLLECTION "ICU TOOLBOX" EditorialBroad use of processed EEG: ready for prime time yet?Rasulo F...