Vitamin D and Sepsis Incidence and Mortality In Sepsis Wed, 1 Apr 2026 A recent article investigates the association between vitamin D status and the incidence of sepsis and subsequent mortality, using a large, population-based prospective cohort derived from the U.K. Biobank. Sepsis, a life-threatening organ dysfunction caused by a dysregulated immune response to infection, represents a major global health burden with high mortality, significant he...

Research Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial Lizi Zhang, Shilei Bi, Lian Chen, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2026-089636 (Published 13 May 2026)Cite this as: BMJ 2026;393:e089636 Abstract Objective To investigate whether prophylactic tranexamic acid reduces the incidence of postpartum haem...

Original Investigation  Life Expectancy in Chronic Obstructive Pulmonary Disease Surya P. Bhatt, Yifei Sun, Yuhan Wang, et al JAMA Intern Med Published Online: May 17, 2026 doi: 10.1001/jamainternmed.2026.0207 Key Points Question  What is the association of chronic obstructive pulmonary disease (COPD) with life expectancy and does this vary by severity of airflow obstruction? Findings &n...

ONLINE FIRST (FREE ACCESS) ARDS 60TH ANNIVERSARY What’s New in Intensive Medicine  The emerging role of diaphragm neurostimulation in ARDSDres, M., Heunks, L. & Goligher, E.C. Understanding the Disease Perioperative ARDS: beyond definitions toward etiology-driven care.Romagnoli, S., Ball, L. & Jaber, S. LATEST ARTICLES Original The predicted body weight equation overestimates lung sizes of female, critically ill patients: an analysis o...

Original Investigation  Less Is More Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial Alastair D. Hay, Samantha Abbs, Matthew Ridd, et al JAMA Intern Med Published Online: May 18, 2026 doi: 10.1001/jamainternmed.2026.1426 Key Points Question  Can a rapid multiplex microbiological point-of-care test (RM-POCT) safely reduce ...

Polymyxin B Haemoadsorption in Endotoxic Septic Shock In Sepsis Wed, 1 Apr 2026 A new article reports the findings of the Tigris trial investigating the efficacy and safety of polymyxin B haemoadsorption in patients with endotoxic septic shock (ESS). ESS is a severe subtype of septic shock characterised by high circulating endotoxin levels and multiorgan failure, and is associated with a high mortality rate. Given the absence of targeted therapies for ...

Original Investigation  Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial William J. Meurer, Sharon D. Yeatts, Romergryko G. Geocadin, et al JAMA Published Online: August 5, 2026 doi: 10.1001/jama.2026.10247 Key Points Question  In comatose survivors of out-of-hospital cardiac arrest treated with therapeutic hypothermia at 33 °C, what duration of cooling maximizes neurological re...

Articles The impact of artificial intelligence-driven decision support on uncertain antimicrobial prescribing: a randomised, multimethod study William J Bolton, Richard Wilson, Mark Gilchrist, et al Lancet Digital Health 2025; 7: 100912 https://doi.org/10.1016/j.landig.2025.100912 Summary Background Challenges exist when translating artificial intelligence (AI)-driven clinical decision support systems (CDSSs) from research into health-care settings, p...

JAMA Clinical Guidelines Synopsis  Perioperative Cardiovascular Medication Management for Noncardiac Surgery David E. Winchester, Jeet J. Mehta, Jason T. Alexander JAMA 2026;335;(19):1717-1718. doi:10.1001/jama.2026.0067 Guideline title 2024 AHA/ACC/ACS/ASNC/HRS/SCA/SCCT/SCMR/SVM Guideline for Perioperative Cardiovascular Management for Noncardiac Surgery Release date September 24, 2024 Prior version 2014 Developers and funding sources&...

Broad-Spectrum Targeted Next-Generation Sequencing In ICU Thu, 9 Apr 2026 A recent commentary by Tseng et al. examines the clinical utility and practical challenges of implementing targeted next-generation sequencing (tNGS) for diagnosing severe pneumonia in ICU settings. While tNGS has demonstrated superior analytical sensitivity compared with conventional microbiological tests (CMTs), its real-world clinical value remains uncertain, particularly in t...