Invited Commentary  Nephrology AI-Enabled Acute Kidney Injury Prediction and the Challenge of Prevention Charat Thongprayoon, Francesco Pesce, Wisit Cheungpasitporn JAMA Netw Open 2026;9;(7):e2622565. doi:10.1001/jamanetworkopen.2026.22565 Acute kidney injury (AKI) remains one of the most common, serious, and consequential complications of hospitalization. It is associated with longer hospital stays, higher costs, greater short-term and long-term morta...

Original Investigation  U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure Hua Wang, Liwei Zhang, Chen Ji, et al JAMA Cardiol Published Online: August 5, 2026 doi: 10.1001/jamacardio.2026.2779 Key Points Question  What is the association between left ventricular dimension and mortality in patients with heart failure? Findings  In thi...

Multidisciplinary Telemedicine Intervention for ICU Recovery In ICU Tue, 7 Jul 2026 A randomised controlled trial evaluated the feasibility of delivering a multidisciplinary telemedicine ICU recovery clinic for survivors of critical illness and of collecting long-term recovery outcomes. Survivors of sepsis and acute respiratory distress syndrome (ARDS) frequently develop post-intensive care syndrome (PICS), which encompasses persistent cognitive, psych...

Original Investigation  Nephrology Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial Matthew M. Churpek, Aiman Fatima, Olasunkanmi Anjorin, et al JAMA Netw Open 2026;9;(7):e2622554. doi:10.1001/jamanetworkopen.2026.22554 Key Points Question  Among inpatients at risk for severe acute kidney injury (AKI), does an early structured nephrology consultat...

Research Letter  Pacific Coast Surgical Association Faculty and Resident Perceptions of Learning Activities During Surgery Residency David M. Rosenberg, Cooper Nagaki, Christian de Virgilio, et al JAMA Surg 2026;161;(10):1093-1095. doi:10.1001/jamasurg.2026.3208 Nonclinical resident educational activities in general surgery residency, such as morbidity and mortality conference (M&M), are vital to the maturation of trai...

Editorial  Trials Terminated Early: When Is Enough, Enough? Alison J. Huang, Roger J. Lewis JAMA Published Online: August 5, 2026 doi: 10.1001/jama.2026.8878 What does it mean to stop a clinical trial early? In the early days of the modern randomized trial, it meant the research had not gone according to plan.1 Trialists were expected to adhere to the sample sizes they originally proposed based on early assumptions about underlying event rates, loss to...

Article HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial Cecconi, M., Cortegiani, A., Noto, A. et al Intensive Care Med 52, 1619–1634 (2026) https://doi.org/10.1007/s00134-026-08501-7 Abstract Purpose The optimal mean arterial pressure (MAP) target in high-risk hypertensive patients undergoing major abdominal surgery remains uncle...

Chest Infections: Original Research Clinical Sampling Challenges in Diagnosing Severe Respiratory Viral Infections Antonio Piralla, Cristina Russo, Stefania Ranno, et al Chest 2026; 170: 41-53 https://doi.org/10.1016/j.chest.2025.12.056 Background Respiratory viruses are a primary cause of pneumonia in both children and adults, particularly in cases of severe acute respiratory infection (SARI) requiring hospitalization. Although molecular diagnostic tech...

Invited Commentary  Anesthesiology A New Trial to Better Define the Role of Video Laryngoscopes Luc Desmedt, Jean-Baptiste Lascarro JAMA Netw Open 2026;9;(8):e2625982. doi:10.1001/jamanetworkopen.2026.25982 Endotracheal intubation is among the most frequently performed high-stakes procedures in anesthesiology. In the operating room (OR), it is usually planned, controlled, and uneventful; outside the OR, it may occur in critically ill patients with litt...

Critical Care: Original Research The Effects of Targeted Mild Hypercapnia on Right Ventricular Function After Out-of-Hospital Cardiac Arrest: A Substudy of the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest Trial Mathias Baumann Melberg, Susanne D. Rootwelt, Arnljot Flaa, et al Chest 2026; 170: 105-117 https://doi.org/10.1016/j.chest.2025.11.017 Background Targeting hypercapnia during invasive mechanical ventilation with subseque...