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Editorial September 13, 2017 Counting Sepsis, an Imprecise but Improving Science Kristina E. Rudd, Anthony Delaney, Simon Finfer AMA. 2017;318(13):1228-1229. doi:10.1001/jama.2017.13697 Sepsis, most succinctly defined as organ dysfunction due to infection, is estimated to account for more than 5 million deaths around the world each year and to cause or contribute to approximately half of all deaths occurring in hospitals in the United States.1,2 A 2016 report from the...
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High-Frequency Oscillation in Acute Respiratory Distress Syndrome: The End of the Story? Vincent JL. Am J Respir Crit Care Med 2017; 196: 670-671 Acute respiratory distress syndrome (ARDS) is still associated with considerable morbidity and mortality (1). It is characterized by acute onset of diffuse inflammatory lung injury, which causes increased pulmonary vascular permeability, leading to increased lung weight, loss of aerated lung tissue, decreased lung compliance, and...
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CORRESPONDENCE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis N Engl J Med 2017; 377:994-995 DOI: 10.1056/NEJMc1708979 The authors reply: In response to Saleh: we do not have specific information on monitoring in the usual-care (control) groups. However, all three original trials1-3 were conducted at sites that did not systematically apply any protocolized approach to resuscitation of patients with sepsis as part of usual care and, by definit...
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News > Reuters Health Information Hypervirulent Carbapenem-resistant Klebsiella Pneumoniae Emerges By Will Boggs MD September 08, 2017 NEW YORK (Reuters Health) - An ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae caused a fatal outbreak in a Chinese hospital and could pose a threat elsewhere, researchers report. 研究人员报告,一种ST11耐碳青霉烯高毒力肺炎克雷白杆菌在一家中国医院内导致致死性暴发流行,且可能对其他地区造成危害。 “This new type of superbug...
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CORRESPONDENCE Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis N Engl J Med 2017; 377:994-995 DOI: 10.1056/NEJMc1708979 To the Editor: 致编辑 In reporting the results of their meta-analysis of individual patient data from three trials, the Protocolized Resuscitation in Sepsis Meta-Analysis (PRISM) investigators (June 8 issue)1 conclude that early, goal-directed therapy (EGDT) did not result in better outcomes than usual care in the resuscit...
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Fluid Challenge: Its Impact on Fluid Responsiveness The fluid challenge is considered the gold standard for diagnosis of fluid responsiveness. A new systematic review finds that the duration of the fluid infusion in a fluid challenge has a significant influence on fluid responsiveness – i.e., a rapid infusion increases the proportion of patients with a positive response. However, the type and volume of fluid or the time of assessment does not appear to have any effect o...
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[编者按]:2017年4月8日,我们在网站上介绍了JAMA在线发表的RCT结果:肺保护性通气基础上肺复张对术后肺部并发症的影响。近日,JAMA刊登了两封读者来信,对该研究结果提出了自己的看法。 Comment & Response August 15, 2017 Alveolar Recruitment Strategies After Cardiac Surgery—Reply Marcelo B. P. Amato, Marcia S. Volpe, Ludhmila A. Hajjar JAMA. 2017;318(7):668-669. doi:10.1001/jama.2017.8697 In Reply Drs Li and Shi raised concerns about which of our study groups actually provided...
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Global Study: Most ICU Patients Underfed A large international multicentre cohort study shows that most of the patients are underfed during their ICU stay. In their findings published in the journal Clinical Nutrition, researchers say most of the patients in intensive care are receiving the same amount of calories regardless of their condition, patient's well-being is not satisfied, and delayed nutrition is more frequent. The findings show poor adherence to nutritional gu...
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[编者按]:2017年4月8日,我们在网站上介绍了JAMA在线发表的RCT结果:肺保护性通气基础上肺复张对术后肺部并发症的影响。近日,JAMA刊登了两封读者来信,对该研究结果提出了自己的看法。 Comment & Response August 15, 2017 Alveolar Recruitment Strategies After Cardiac Surgery Guohui Li, Xueyin Shi JAMA. 2017;318(7):667. doi:10.1001/jama.2017.8689 To the Editor Dr Costa Leme and colleagues1 reported that an intensive alveolar recruitment strategy resulted in less-severe pulmonary...
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