Vitamin D and Sepsis Incidence and Mortality In Sepsis Wed, 1 Apr 2026 A recent article investigates the association between vitamin D status and the incidence of sepsis and subsequent mortality, using a large, population-based prospective cohort derived from the U.K. Biobank. Sepsis, a life-threatening organ dysfunction caused by a dysregulated immune response to infection, represents a major global health burden with high mortality, significant he...

Polymyxin B Haemoadsorption in Endotoxic Septic Shock In Sepsis Wed, 1 Apr 2026 A new article reports the findings of the Tigris trial investigating the efficacy and safety of polymyxin B haemoadsorption in patients with endotoxic septic shock (ESS). ESS is a severe subtype of septic shock characterised by high circulating endotoxin levels and multiorgan failure, and is associated with a high mortality rate. Given the absence of targeted therapies for ...

Broad-Spectrum Targeted Next-Generation Sequencing In ICU Thu, 9 Apr 2026 A recent commentary by Tseng et al. examines the clinical utility and practical challenges of implementing targeted next-generation sequencing (tNGS) for diagnosing severe pneumonia in ICU settings. While tNGS has demonstrated superior analytical sensitivity compared with conventional microbiological tests (CMTs), its real-world clinical value remains uncertain, particularly in t...

EDITORIAL Price of Protection — Microaxial Flow Pump in High-Risk PCI Brahmajee K. Nallamothu, Brett L. Wanamaker N Engl J Med 2026;394:1855-1856 DOI: 10.1056/NEJMe2602727 In the catheterization laboratory, the most consequential decisions are frequently not about whether to treat, but rather about how far to extend treatment. Nowhere is that tension more apparent than in high-risk percutaneous coronary intervention (PCI). In these cases, the margin between...

PERSPECTIVE Can AI Say “I Don’t Know”? Andrea Sikora, Leo A. Celi, Raja-Elie E. Abdulnour N Engl J Med 2026;394:1873-1875 DOI: 10.1056/NEJMp2517624 I will not be ashamed to say “I know not.” — Hippocratic Oath A first-year resident is asked, “What explains the patient’s rising creatinine?” She pauses. “I don’t know ….” The team reviews the patient’s medications and risk factors and chooses a cautious plan involving chec...

Vasoactive Medications and Microcirculation in Septic Shock In Sepsis Thu, 9 Apr 2026 A new review examines the effects of vasoactive medications on the microcirculation in septic shock to synthesise current knowledge and identify gaps in evidence. Sepsis remains a leading cause of inpatient mortality, with rates approaching 30%, and although management strategies focus on restoring macrohaemodynamic parameters such as mean arterial pressure (MAP) and ...

Invited Commentary  Exchange Transfusion for Severe Babesiosis—Insights From a Multicenter Retrospective Analysis Eric A. Meyerowitz, Johanna P. Daily JAMA Intern Med 2026;186;(5):607-608. doi:10.1001/jamainternmed.2026.0252 Babesia microti is a tickborne intraerythrocytic parasite reported in at least 24 states across the US, with 1827 cases reported in 2020.1 Rising cases have been attributed to climate and weather changes across the country. Severe bab...

Editorial  Dapagliflozin to Reduce the Risk of Perioperative Acute Kidney Injury in Elective Cardiac Surgery Wolfgang C. Winkelmayer, Glenn M. Chertow JAMA Published Online: July 30, 2026 doi: 10.1001/jama.2026.7477 Sodium-glucose cotransporter 2 (SGLT2) inhibitors have constituted a major advancement for the treatment of patients with chronic kidney disease and/or heart failure, with sizeable benefits in reducing progression of kidney disease and in r...

Editorial  The Price of Advice—Do Management Consultants Deliver Value to Nonprofit Hospitals? Thomas C. Buchmueller, Helen G. Levy JAMA Published Online: May 4, 2026 doi: 10.1001/jama.2026.4362 In a well-publicized case that stoked public outrage, Providence, a nonprofit health system headquartered in the state of Washington, implemented a program in 2018 called Rev Up to increase revenue collection from patients.1 Following enforcement action by the ...

R2D2-ICU: Restrictive vs Liberal Physical Restraint Strategies In ICU Tue, 17 Mar 2026 Findings from the Restrictive Use of Restraints and Delirium Duration in ICU (R2D2-ICU) trial were presented at the 45th ISICEM in Brussels. The trial investigated whether a restrictive (low-use) versus liberal (high-use) wrist-strap physical restraint strategy improves outcomes in critically ill adults receiving invasive mechanical ventilation. Physical restraint...