Suspension-Based Lower-Limb Rehabilitation for ICU-Acquired Weakness In ICU Wed, 21 Jan 2026 A recent trial evaluated the short-term efficacy of a suspension-based lower-limb rehabilitation device (SS) in patients with intensive care unit–acquired weakness (ICUAW). ICUAW is a frequent and serious complication of critical illness, characterised by symmetrical limb weakness, prolonged mechanical ventilation, functional impairment, and reduced quality of ...

Invasive & Non-Invasive Monitoring of Inspiratory Effort & Drive in Assisted Mechanical Ventilation In ICU Wed, 21 Jan 2026 A clinical review examined the invasive and non-invasive monitoring of inspiratory effort and respiratory drive in patients undergoing assisted mechanical ventilation (AMV). Following the acute phase of respiratory failure, AMV is commonly used to support spontaneous breathing, improve gas exchange, and reduce sedation req...

Invited Commentary  Infectious Diseases Is It Time to Use Single-Dose Amphotericin B for HIV-Related Cryptococcal Meningitis? Nathan C. Bahr, Radha Rajasingham, David R. Boulware JAMA Netw Open 2026;9;(1):e2553489. doi:10.1001/jamanetworkopen.2025.53489 Cryptococcal meningitis remains a life-threatening opportunistic infection among people with advanced HIV, even in high-resource settings. For decades, the standard induction regimen in the United State...

Acute Respiratory Distress Syndrome Molecular Phenotypes In ICU Wed, 21 Jan 2026 A new study investigated whether the two well-established molecular phenotypes of acute respiratory distress syndrome (ARDS)—hyperinflammatory and hypoinflammatory—are associated with distinct biological processes in the lung. Although these phenotypes were originally defined using plasma biomarkers and clinical variables and are known to differ in prognosis and treatment ...

ICU Dashboard Tracks Environmental Impact In ICU Tue, 13 Jan 2026 Green initiatives in Intensive Care Units (ICUs) increasingly focus on reducing the environmental footprint of routine care. Common measures include lowering glove use, replacing absorption pads with towels and shifting from disposable clothing to washable alternatives. While such actions are relatively simple to introduce, sustaining them requires structured monitoring. ICU teams need r...

Poetry and Medicine  28 Hours in the ICU Kaveh Danesh JAMA Published Online: March 11, 2026 doi: 10.1001/jama.2026.0660 I watch the sunrise I watch the sunset I watch the body fall apart while we tilt the horizon away from light knowing the sun setting in the West is rising in the East. I watch the sunrise I watch the sunrise I watch your pupils suspended midday between two horizons. [JAMA编者按]：ICU中的...

Redefining Sepsis Through Host–Microbe Dynamics In Sepsis Thu, 15 Jan 2026 Current approaches to classifying sepsis are limited because they rely too heavily on clinical features and host-only immune responses, while largely ignoring the role of the infecting microbes. Sepsis is a heterogeneous syndrome, and grouping patients based on clinical signs alone assumes a single underlying mechanism, which is often incorrect. This has hindered progress in und...

Invited Commentary  From Balanced Blood Products to Personalized Medicine in Acute Resuscitation of Trauma Patients Taylor E. Wallen, John B. Holcomb JAMA Surg Published Online: March 11, 2026 doi: 10.1001/jamasurg.2026.0195 Resuscitation of patients experiencing hemorrhagic shock has changed tremendously over the last 30 years, moving from crystalloid and red blood cells to balanced components, and now with whole blood (WB) administration gaining favo...

Weaning from VV-ECMO: Data from ESICM-Endorsed WEAN-ECMO Survey In ICU Thu, 15 Jan 2026 The use of venovenous extracorporeal membrane oxygenation (VV ECMO) for severe acute respiratory distress syndrome (ARDS) has risen substantially, and current guidelines recommend VV ECMO in selected patients to maintain adequate gas exchange while limiting ventilator-induced lung injury. Despite this, several critical components of ECMO management remain poorly sta...

Invited Commentary  Pediatrics Respiratory Management of Neonatal Acute Respiratory Distress Syndrome Lucy Loft, David G. Tingay JAMA Netw Open 2026;9;(3):e260220. doi:10.1001/jamanetworkopen.2026.0220 High frequency oscillatory ventilation (HFOV) has been used to treat respiratory failure in neonates since the early 1990s.1 HFOV supports gas exchange by delivering very low tidal volumes at fast rates (>2 Hz). Theoretically, these characteristics of HF...