Editorial  November 11, 2024 Intratracheal Budesonide Combined With Surfactant in Extremely Preterm Infants Erik A. Jensen JAMA. Published online November 11, 2024. doi:10.1001/jama.2024.19641 Infants born extremely premature (those with gestational ages of less than 28 weeks at delivery) are at risk of both acute and subsequent chronic respiratory insufficiency due in part to absent or inadequate production of pulmonary surfactant. More than...

Restrictive vs Liberal Transfusion Strategy in Acute Brain Injury In ICU Mon, 14 Oct 2024 The indications for red blood cell transfusions in critically ill patients without life-threatening bleeding are debated, particularly due to the balance between risks and benefits. While anaemia is linked to increased morbidity and mortality, blood transfusions can also lead to complications such as infection or lung injury. Several randomised clinical trials in ...

Editorial  September 25, 2024 Feasibility of Fever Prevention in Vascular Brain Injury Teresa May, Lori Shutter JAMA. 2024;332(18):1521-1522. doi:10.1001/jama.2024.16415 How to manage fever in the neurocritical care unit in patients with acute stroke was clearly a question in need of an answer. The association of fever burden with poor outcome for diverse conditions in the neurocritical care unit has been well described.1-3 However, distinguishing asso...

Telemedicine vs Emergency Department for Opioid Use Disorder In ICU Wed, 24 Jul 2024 A new study shows that telemedicine referrals for patients with opioid use disorder (OUD) are more effective than in-person emergency department visits for initiating and maintaining medication-assisted treatment (MAT) through outpatient clinics. The findings are published in the Journal of Substance Use and Addiction Treatment. This is the first study comparing tel...

Using AI to Examine Brain Activity Following TBI In ICU Wed, 24 Jul 2024

Sepsis Alert Systems, Mortality, Adherence to SSC In Sepsis Wed, 24 Jul 2024 Sepsis is a global health issue with high mortality and morbidity rates among hospitalised patients. To enhance the quality of sepsis management, the Surviving Sepsis Campaign (SSC) developed an evidence-based bundle comprising five key elements to be implemented within the first hours of sepsis recognition. These elements include fluid resuscitation with 30 mL/kg of crystallo...

Sepsis Patients Could Get Faster Treatment In Sepsis Fri, 21 Jun 2024 Patients with sepsis could be treated based on their immune system’s response to infection rather than their symptoms. New research has revealed that people’s genetic makeup significantly influences their response to sepsis. This understanding could help identify those who would benefit from specific treatments and pave the way for developing targeted therapies. The findings are p...

Renal Protective Effect, Role of Vitamin B6 in Sepsis In Sepsis Sun, 23 Jun 2024 Sepsis can progress to multiple organ dysfunction syndrome or multiorgan failure. Globally, sepsis-related deaths are estimated at 11 million annually, representing 19.7% of total deaths, with a global age-standardised death rate of 148.1 per 100,000 people. Despite advancements in treatment, the case fatality rate for sepsis remains high at 30% to 70%. Treating sepsis is ...

The Way to a Patient’s Heart — Vascular Access in Cardiac Arrest Niklas Nielsen N Engl J Med Published October 31, 2024 DOI: 10.1056/NEJMe2412901 Every year, thousands of lives are saved with cardiopulmonary resuscitation (CPR). Yet, overall survival among patients with out-of-hospital cardiac arrest is approximately 10%, even in well-performing emergency medical systems. The interventions that are undertaken at the scene of a cardiac arrest are the most likel...

Organ Donation After Extracorporeal Cardiopulmonary Resuscitation In ICU Sat, 22 Jun 2024 With the global demand for organ transplants on the rise, the shortage of available organs has worsened, leaving the supply insufficient to meet the growing need. One way to address this crisis is to identify potential organ donors, particularly by screening for brain death in ICUs, especially after cardiac arrest. Extracorporeal cardiopulmonary resuscitation (...