Human-Centred AI in Critical Care  In ICU Thu, 11 Dec 2025 A recent review advocates for a fundamental shift in how artificial intelligence is integrated into intensive care units, moving away from a narrow focus on model development towards comprehensive human-centred AI system design. The discussion is based on the World Health Organization’s 2021 ethical framework, which establishes six core principles for AI in healthcare: protecting human aut...

ImmunoSep: Precision Immunotherapy to Improve Sepsis Outcomes  In Sepsis Thu, 11 Dec 2025 Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Many immunotherapy trials have failed because sepsis presents with highly variable immune states, ranging from excessive inflammation to profound immunosuppression. A precision-medicine approach, guided by rapid biomarker-based immune profiling, may therefore be need...

Metabolic Shifts Precede Sepsis Organ Dysfunction In Sepsis Wed, 6 Aug 2025 Sepsis is a severe condition causing widespread organ damage and failure, affecting multiple systems like cardiovascular, immune, and metabolic. Understanding of the mechanisms remains limited, hindering targeted treatments. Metabolism, especially mitochondrial dysfunction, has emerged as a key factor in sepsis progression. Biomarkers like lactate are commonly used, though t...

What Drives ICU Staff to Act on Sustainability  In ICU Mon, 10 Nov 2025 Environmental sustainability is an increasingly visible challenge in intensive care, where resource-intensive care processes intersect with rising expectations for greener practice. Evidence from a multi-centre survey across nine French hospitals offers a detailed view of how intensive care unit (ICU) healthcare workers (HCWs) approach this agenda, how much time they are willi...

Invited Commentary  Trauma Patient Volume and Clinician Outcomes—Practice Makes Perfect? Kenji Inaba, Nichole Bosson JAMA Surg Published Online: February 18, 2026 doi: 10.1001/jamasurg.2025.6752 Regionalization is a standard across many industries, with well-defined benefits in terms of resource aggregation, improved efficiency, and downstream cost savings. By concentrating expertise and experience, it also stands to reason that, for the care of the in...

International Severity of Illness Scoring System In ICU Wed, 26 Nov 2025 Developing a globally applicable critical care severity score is an urgent priority for improving research, benchmarking, quality improvement, and public health response across diverse health systems. Severity scores have long been central to ICU practice, supporting benchmarking, risk adjustment, resource allocation, and disease characterisation. Yet, most existing scores were de...

Editorial  Evaluating Cryopreserved and Liquid-Stored Platelets for Bleeding During Cardiac Surgery Timothy A. Pritt JAMA Surg Published Online: February 18, 2026 doi: 10.1001/jamasurg.2025.6723 There is no substitute for blood during the treatment of hemorrhage. From the first reported successful transfusion of human blood to treat postpartum hemorrhage in 1825,1 to the early use of whole blood in combat casualty care during World War I,2 an...

Invited Commentary  Anesthesiology Antibiotic Selection and Redosing to Prevent Surgical Site Infections—When Timing Is Not Enough Nicole A. Wilson JAMA Netw Open 2026;9;(2):e2559356. doi:10.1001/jamanetworkopen.2025.59356 Surgical site infections (SSIs) remain among the most common and costly complications following surgery, despite decades of quality improvement efforts. In this context, the multicenter cohort study by Bardia et al1 provides timely a...

LTVV and Mortality in Patients With Acute Brain Injury In ICU Wed, 19 Nov 2025 A recent study examined whether low-tidal-volume ventilation (LTVV) is associated with lower mortality in mechanically ventilated patients with acute brain injury (ABI).  LTVV has become standard care in patients with acute respiratory distress syndrome (ARDS) but its use in the ABI population remains controversial due to concerns about intracranial hypertension and the ...

Predictive Modelling for Respiratory Support With LLM-Driven Guideline In ICU Wed, 19 Nov 2025 A research study from the University of California, San Diego, describes an innovative approach to improving respiratory support decisions in intensive care units by integrating a large language model with an existing deep learning system. The work addresses a critical clinical challenge: determining whether patients at high risk of requiring invasive mechanical ...