Original Investigation  AI in Medicine Individualized Prediction of Platelet Transfusion Outcomes in Preterm Infants With Severe Thrombocytopenia Hilde van der Staaij, Ilaria Prosepe, Camila Caram-Deelder, et al JAMA 2025;334;(14):1267-1277. doi:10.1001/jama.2025.14194 Key Points Question  When and in which preterm infants with severe thrombocytopenia do platelet transfusions reduce the risk of major bleeding or death? Findings &nb...

Research Letter  Social Media Use Trajectories and Cognitive Performance in Adolescents Jason M. Nagata, Jennifer H. Wong, Kristen E. Kim, et al JAMA Published Online: October 13, 2025 doi: 10.1001/jama.2025.16613 Social media is an increasingly important aspect of early adolescent lives, and trajectories of use have been correlated with negative psychosocial outcomes.1,2 Studies of the link between total screen time and cognitive performance in those ...

Two cases of Middle East respiratory syndrome (MERS) in travellers returning to France from the Arabian Peninsula Epidemiological update 5 Dec 2025 On 3 December 2025, the French Ministry of Health reported two imported human Middle East respiratory syndrome (MERS) cases with travel history to the Arabian Peninsula. The two affected individuals participated in the same group trip. No secondary cases have been identified so far. French authorities are implement...

Original Investigation  Health Informatics Use of an AI Scribe and Electronic Health Record Efficiency Kevin Pearlman, Wen Wan, Sachin Shah, et al JAMA Netw Open 2025;8;(10):e2537000. doi:10.1001/jamanetworkopen.2025.37000 Key Points Question  Is an ambulatory clinician’s use of an artificial intelligence (AI) scribe associated with improved efficiency in the electronic health record (EHR) when compared w...

Original Investigation  Critical Care Medicine One-Year Outcomes After Traumatic Brain Injury and Early Extracranial Surgery in the TRACK-TBI Study Christopher J. Roberts, Amelia W. Maiga, Jason Barber, et al JAMA Netw Open 2025;8;(10):e2537271. doi:10.1001/jamanetworkopen.2025.37271 Key Points Question  Are traumatic brain injury (TBI) outcomes at 1 year worse in individuals exposed to extracranial surge...

Original Investigation  Public Health Air Purifier Intervention for Respiratory Viral Exposure in Elementary Schools: A Secondary Analysis of a Randomized Clinical Trial Ye Sun, Dastan Haghnazari, Ching-Ying Huang, et al JAMA Netw Open 2025;8;(10):e2536951. doi:10.1001/jamanetworkopen.2025.36951 Key Points Question  Is the use of high-efficiency particulate air (HEPA) purifiers associated with reduced res...

Research Special Paper Patterns of war related trauma in Gaza during armed conflict: survey study of international healthcare workers Omar El-Taji, Ameer Ali, Osaid Alser, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-087524 (Published 25 September 2025)Cite this as: BMJ 2025;390:e087524 Abstract Objective To systematically document the patterns of war related injuries in Gaza, Palestine. Design Survey study of international he...

Research Non-invasive high frequency oscillatory ventilation for primary respiratory support in extremely preterm infants: multicentre randomised controlled trial Yang Li, Xingwang Zhu, Ling-Jun Li, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-085569 (Published 06 October 2025)Cite this as: BMJ 2025;391:e085569 Abstract Objective To test the hypothesis that non-invasive high frequency oscillatory ventilation (NHFOV) is more efficacious tha...

Original Investigation  Aging and Health Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Clinical Trial Babar A. Khan, Sikandar H. Khan, Anthony J. Perkins, et al JAMA Intern Med Published Online: October 13, 2025 doi: 10.1001/jamainternmed.2025.5263 Key Points Question  Among critically ill, mechanically ventilated older adults ...

Original Investigation  Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.18007 Key Points Question  Does intraoperative blood pressure management with a mean arterial pressure goal stratified by preoperatively determined ...