Research Effectiveness of drug interventions to prevent delirium after surgery for older adults: systematic review and network meta-analysis of randomised controlled trials Matthew Luney, Luke Holdsworth, Arwa Hanaga, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085539 (Published 12 February 2026)Cite this as: BMJ 2026;392:e085539 Abstract Objective To identify which drugs are effective at preventing...

Articles Survival effect of prehospital emergency anaesthesia with intubation in risk-stratified patients with major trauma: a causal modelling study Amy PK Nelson, Nick Dodds, Mohamad Zeina, et al Lancet Respir Med Available online 11 February 2026 https://doi.org/10.1016/S2213-2600(25)00370-4 Summary Background Trauma is among the top 10 most common causes of disability worldwide, accounting for more than 100 million disability-adjusted life-years (...

Original Investigation  Surgery Antibiotic Prophylaxis Strategies and Surgical Site Infections in Colorectal Surgery: A Systematic Review and Network Meta-Analysis Shahrzad Motaghi, Samer G. Karam, Francesca Mulazzani, et al JAMA Netw Open 2026;9;(2):e2560095. doi:10.1001/jamanetworkopen.2025.60095 Key Points Question  Which antibiotic prophylaxis regimens are associated with the lowest risk of surgical s...

Guideline-Driven LLM Boosts Sepsis Mortality Prediction  In Sepsis Tue, 2 Dec 2025 Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance and advances in treatment, outcomes for many patients remain poor and early identification of those at highest risk continues to be challenging. Conventional risk scores and tradi...

Original Investigation  Statistics and Research Methods Design and Implementation of Observational Studies Emulating a Target Trial Yan Ren, Yulong Jia, Lingyan Liu, et al JAMA Netw Open 2026;9;(2):e2558262. doi:10.1001/jamanetworkopen.2025.58262 Key Points Question  In which clinical scenarios has target trial emulation (TTE) been applied, and how well do TTE studies adhere to key principles of target tr...

Original Investigation  Critical Care Medicine Albumin Replacement Therapy in Septic Shock: A Randomized Clinical Trial Yasser Sakr, Axel Nierhaus, Ulrike Schumacher, et al JAMA Netw Open 2026;9;(2):e2559297. doi:10.1001/jamanetworkopen.2025.59297 Key Points Question  Can the reported potential mortality reduction by albumin replacement in septic shock be confirmed in a randomized clinical trial? Findi...

Original Investigation  Emergency Medical Individual Clinician Volume and Mortality in Trauma Patients Jamison Beiriger, Christian Martin-Gill, David S. Silver, et al JAMA Surg Published Online: February 18, 2026 doi: 10.1001/jamasurg.2025.6741 Key Points Question  Is the patient volume of individual emergency medical services (EMS) clinicians associated with trauma patient outcomes? Findings...

Research Letter  Pediatrics Clinical Decision Support for Antibiotic Prescribing Duration in Children With Acute Otitis Media Matt Mason, Sara Ruth Slovin, Arezoo Zomorrodi, et al JAMA Netw Open 2026;9;(2):e2560066. doi:10.1001/jamanetworkopen.2025.60066 Introduction Acute otitis media (AOM) is the most common indication for antibiotics in children.1 The American Academy of Pediatrics recommends 10 days of the...

Original Investigation  Nutrition, Obesity, and Exercise Leisure-Time Physical Activity and Cancer Mortality Among Cancer Survivors Erika Rees-Punia, Lauren R. Teras, Christina C. Newton, et al JAMA Netw Open 2026;9;(2):e2556971. doi:10.1001/jamanetworkopen.2025.56971 Key Points Question  Is engagement in physical activity after a cancer diagnosis associated with longer survival among individuals with a h...

Original Investigation  Anesthesiology Guideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery Amit Bardia, MBBS, Hung-Mo Lin, Xiwen Zhao, et al JAMA Netw Open 2026;9;(2):e2559349. doi:10.1001/jamanetworkopen.2025.59349 Key Points Question  What is the association of adherence to Infectious Diseases Society of America (IDSA) perioperative antibiotic prophylaxis ...