Original Investigation  U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure Hua Wang, Liwei Zhang, Chen Ji, et al JAMA Cardiol Published Online: August 5, 2026 doi: 10.1001/jamacardio.2026.2779 Key Points Question  What is the association between left ventricular dimension and mortality in patients with heart failure? Findings  In thi...

Original Investigation  Nephrology Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial Matthew M. Churpek, Aiman Fatima, Olasunkanmi Anjorin, et al JAMA Netw Open 2026;9;(7):e2622554. doi:10.1001/jamanetworkopen.2026.22554 Key Points Question  Among inpatients at risk for severe acute kidney injury (AKI), does an early structured nephrology consultat...

Research Letter  Pacific Coast Surgical Association Faculty and Resident Perceptions of Learning Activities During Surgery Residency David M. Rosenberg, Cooper Nagaki, Christian de Virgilio, et al JAMA Surg 2026;161;(10):1093-1095. doi:10.1001/jamasurg.2026.3208 Nonclinical resident educational activities in general surgery residency, such as morbidity and mortality conference (M&M), are vital to the maturation of trai...

Article HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial Cecconi, M., Cortegiani, A., Noto, A. et al Intensive Care Med 52, 1619–1634 (2026) https://doi.org/10.1007/s00134-026-08501-7 Abstract Purpose The optimal mean arterial pressure (MAP) target in high-risk hypertensive patients undergoing major abdominal surgery remains uncle...

Critical Care: Original Research The Effects of Targeted Mild Hypercapnia on Right Ventricular Function After Out-of-Hospital Cardiac Arrest: A Substudy of the Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest Trial Mathias Baumann Melberg, Susanne D. Rootwelt, Arnljot Flaa, et al Chest 2026; 170: 105-117 https://doi.org/10.1016/j.chest.2025.11.017 Background Targeting hypercapnia during invasive mechanical ventilation with subseque...

Pulmonary Vascular: Original Research The Effect of a 2-Day Stay at High Altitude (2,500 m) on Right Ventricular Afterload and Oxygen Delivery in Patients With Pulmonary Vascular Disease: A Randomized Controlled Crossover Trial Julian Müller, Simon R. Schneider, Meret Bauer, et al Chest 2026 Available online 3 July 2026 https://doi.org/10.1016/j.chest.2026.06.032 Background High altitude may adversely affect patients with pulmonary vascular disease (PVD)...

Critical Care: Original Research The ARDS, Pneumonia, and Sepsis Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes Wesley H. Self, Carolyn S. Calfee, Samuel M. Brown, et al Chest 2026 Available online 13 July 2026 https://doi.org/10.1016/j.chest.2026.05.053 Background To enhance biological understanding of ARDS, pneumonia, and sepsis and to accelerate therapeutic development in these areas, t...

Critical Care: Original Research Diagnostic Yield of CT Imaging and Point-of-Care Ultrasound After In-Hospital Cardiac Arrest Luke Andrea, Jack Galfund, Lewis A. Eisen, et al Chest 2026; 170: 118-127 https://doi.org/10.1016/j.chest.2026.02.023 Abstract Background CT imaging and point-of-care ultrasound (POCUS) have demonstrated usefulness after out-of-hospital cardiac arrest (OHCA), but their diagnostic yield and impact after in-hospital cardiac arres...

Original Investigation  Anesthesiology Conventional vs Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubations: A Randomized Clinical Trial Benedikt Schmid, Linda Grüßer, Lukas Müller, et al JAMA Netw Open 2026;9;(8):e2625965. doi:10.1001/jamanetworkopen.2026.25965 Key Points Question  What are the first-pass success rates for tracheal intubations using video laryngoscopy with a Macintosh b...

Original Investigation  Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults: The SAVE-O2 AI Randomized Clinical Trial David J. Douin, John D. Rice, Mengli Xiao, et al JAMA Intern Med Published Online: August 3, 2026 doi: 10.1001/jamainternmed.2026.4023 Key Points Question  Can autonomous oxygen titration increase the proportion of time acutely ill adults receiving s...