CORRESPONDENCE|ONLINE FIRST Thromboembolism and the Oxford–AstraZeneca COVID-19 vaccine: side-effect or coincidence? Søren Dinesen Østergaard, Morten Schmidt, Erzsébet Horváth-Puhó, et al Lancet Published: March 30, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00762-5 By mid March, 2021, vaccination against COVID-19 using the ChAdOx1 nCoV-19 (AZD1222) vaccine from Oxford–AstraZeneca1, 2was paused in a number of European countries due to reports of thrombo...

ORIGINAL ARTICLE A Microbiota-Directed Food Intervention for Undernourished Children Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, et al N Engl J Med April 7, 2021DOI: 10.1056/NEJMoa2023294 BACKGROUND More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed developme...

ONLINE FIRST (FREE ACCESS)  Abraham P. et al. - Trauma patients do not benefit from a viscoelastic haemostatic assay-guided protocol, but why?MacDonald B. ~Fear and insight in the ICU bedChaudhuri D. et al. -  Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysisEvangelista I. et al. - Renal pyonephrosis with massive pleural empyema Cecconi M. et al. ~ Diversity and inclusivity...

ARTICLES| VOLUME 397, ISSUE 10285, P1637-1645, MAY 01, 2021 Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet 2021; 397: 1637-1645 Summary Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This ran...

ARTICLES| VOLUME 397, ISSUE 10280, P1204-1212, MARCH 27, 2021 Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study Christian Holm Hansen, Daniela Michlmayr, Sophie Madeleine Gubbels, et al. Lancet 2021; 397: 1204-1212 DOI:https://doi.org/10.1016/S0140-6736(21)00575-4 Summary Background 背景 The degree to which infection with SA...

Original Investigation Caring for the Critically Ill PatientMarch 25, 2021 Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial Domenico Luca Grieco, Luca S. Menga, Melania Cesarano, et al JAMA. Published online March 25, 2021. doi:10.1001/jama.2021.4682 Abstract Importance 背...

ARTICLES| VOLUME 397, ISSUE 10283, P1447-1458, APRIL 17, 2021 Effect of infusion set replacement intervals on catheter-related bloodstream infections (RSVP): a randomised, controlled, equivalence (central venous access device)–non-inferiority (peripheral arterial catheter) trial Claire M Rickard, Nicole M Marsh, Emily N Larsen, et al Lancet 2021; 397: 1447-1458 DOI:https://doi.org/10.1016/S0140-6736(21)00351-2 Summary Background The opt...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Ventilator Weaning and Discontinuation Practices for Critically Ill Patients Karen E. A. Burns, Leena Rizvi, Deborah J. Cook, et al JAMA. 2021;325(12):1173-1184. doi:10.1001/jama.2021.2384 Abstract Importance 背景 Although most critically ill patients receive invasive mechanical ventilation (IMV), few studies have characterized ...

ORIGINAL ARTICLE Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial Rianne van Rijn, Ivo J. Schurink, Yvonne de Vries, et al N Engl J Med 2021; 384:1391-1401DOI: 10.1056/NEJMoa2031532 Abstract BACKGROUND Transplantation of livers obtained from donors after circulatory death is associated with an increased risk of nonanastomotic biliary strictures. Hypothermic oxygenated machine perfusion of livers may reduce the incidence of bili...

Original Investigation Caring for the Critically Ill PatientMarch 23/30, 2021 Intubation Practices and Adverse Peri-intubation Events in Critically Ill Patients From 29 Countries Vincenzo Russotto, Sheila Nainan Myatra, John G. Laffey, et al JAMA. 2021;325(12):1164-1172. doi:10.1001/jama.2021.1727 Abstract Importance 背景 Tracheal intubation is one of the most commonly performed and high-risk intervention...