Research Prophylactic tranexamic acid for the prevention of postpartum haemorrhage in women with placenta praevia: multicentre, double blind, randomised, placebo controlled, phase 3 trial Lizi Zhang, Shilei Bi, Lian Chen, et al BMJ 2026; 393 doi: https://doi.org/10.1136/bmj-2026-089636 (Published 13 May 2026)Cite this as: BMJ 2026;393:e089636 Abstract Objective To investigate whether prophylactic tranexamic acid reduces the incidence of postpartum haem...

Original Investigation  Life Expectancy in Chronic Obstructive Pulmonary Disease Surya P. Bhatt, Yifei Sun, Yuhan Wang, et al JAMA Intern Med Published Online: May 17, 2026 doi: 10.1001/jamainternmed.2026.0207 Key Points Question  What is the association of chronic obstructive pulmonary disease (COPD) with life expectancy and does this vary by severity of airflow obstruction? Findings &n...

ONLINE FIRST (FREE ACCESS) ARDS 60TH ANNIVERSARY What’s New in Intensive Medicine  The emerging role of diaphragm neurostimulation in ARDSDres, M., Heunks, L. & Goligher, E.C. Understanding the Disease Perioperative ARDS: beyond definitions toward etiology-driven care.Romagnoli, S., Ball, L. & Jaber, S. LATEST ARTICLES Original The predicted body weight equation overestimates lung sizes of female, critically ill patients: an analysis o...

Original Investigation  Less Is More Rapid Respiratory Microbiological Point-of-Care Testing and Antibiotic Use in Primary Care: A Randomized Clinical Trial Alastair D. Hay, Samantha Abbs, Matthew Ridd, et al JAMA Intern Med Published Online: May 18, 2026 doi: 10.1001/jamainternmed.2026.1426 Key Points Question  Can a rapid multiplex microbiological point-of-care test (RM-POCT) safely reduce ...

Original Investigation  Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest: The ICECAP Randomized Clinical Trial William J. Meurer, Sharon D. Yeatts, Romergryko G. Geocadin, et al JAMA Published Online: August 5, 2026 doi: 10.1001/jama.2026.10247 Key Points Question  In comatose survivors of out-of-hospital cardiac arrest treated with therapeutic hypothermia at 33 °C, what duration of cooling maximizes neurological re...

Articles The impact of artificial intelligence-driven decision support on uncertain antimicrobial prescribing: a randomised, multimethod study William J Bolton, Richard Wilson, Mark Gilchrist, et al Lancet Digital Health 2025; 7: 100912 https://doi.org/10.1016/j.landig.2025.100912 Summary Background Challenges exist when translating artificial intelligence (AI)-driven clinical decision support systems (CDSSs) from research into health-care settings, p...

ORIGINAL ARTICLE A Phase 3 Trial of Brepocitinib in Dermatomyositis Ruth Ann Vleugels, Julie J. Paik, Iazsmin Bauer Ventura, et al N Engl J Med 2026;394:1883-1893 DOI: 10.1056/NEJMoa2503531 Abstract BACKGROUND Brepocitinib is a first-in-class, oral, selective TYK2–JAK1 inhibitor that blocks cytokine signaling, which has been implicated in dermatomyositis. METHODS In this phase 3, double-blind, randomized, place...

ORIGINAL ARTICLE Ensitrelvir for Covid-19 Postexposure Prophylaxis in Household Contacts Frederick G. Hayden, Masaharu Shinkai, Tristan W. Clark, et al N Engl J Med 2026;394:1905-1915 Abstract BACKGROUND Ensitrelvir, an oral inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3C-like protease, is approved in Japan for the treatment of mild-to-moderate coronavirus disease 2019 (Covid-19). Previously...

Original Investigation  Surgery Surgeon Volume and Clinical Outcomes After Robotic Elective and Emergency General Surgery Natasha Houshmand, I-Fan Shih, Alistair J. Kent, et al JAMA Netw Open 2026;9;(5):e2611774. doi:10.1001/jamanetworkopen.2026.11774 Key Points Question  Is annual surgeon robotic case volume associated with outcomes for both elective and emergency robotic general surgery procedures? F...

Original Investigation  Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial Maartina J. P. Oosterom-Eijmael, Abraham H. Hulst, Nelson P. Monteiro de Oliveira, et al JAMA Published Online: July 30, 2026 doi: 10.1001/jama.2026.9268 Key Points Question  Among patients undergoing elective cardiac surgery, does dapagliflozin, initiated 1 day prior to surgery, reduce acute kidney injury at 7 days after su...