Editorial August 27, 2019 Reporting and Interpretation of Randomized Clinical Trials Howard Bauchner, Robert M. Golub, Phil B. Fontanarosa JAMA. 2019;322(8):732-735. doi:10.1001/jama.2019.12056 High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence pyramid, either as stand-alone studies or as part of meta-analyses. However, the interpretation of an RCT is often complicated and involves an understanding of the ...

JAMA Clinical Guidelines Synopsis July 18, 2019 Management of Patients With Acute Ischemic Stroke James R. Brorson, Adam S. Cifu JAMA. Published online July 18, 2019. doi:10.1001/jama.2019.10436 Guideline title 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Release date January 24, 2018 Prior version 2013 Developer American Heart Association (AHA)/American Stroke Association (ASA) Funding ...

JAMA Network Clinical Guideline Synopsis April 17, 2019 The Society of Vascular Surgery Practice Guidelines on the Care of Patients With Abdominal Aortic Aneurysms Michol A. Cooper, Gilbert R. Upchurch Jr JAMA Surg. Published online April 17, 2019. doi:10.1001/jamasurg.2019.0566 Guideline title: The Society for Vascular Surgery Practice Guidelines on the Care of Patients with an Abdominal Aortic Aneurysm 指南标题：血管外科学会腹主动脉瘤患者诊...

ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients Question 1: Can we recommend the use of risk prediction models in daily clinical practice?我们能否推荐工作中采用风险预测模型？ Recommendations 推荐意见 Risk prediction models, because of their simplicity and high negative predictive values, should be used for identifying high-risk patients (Strong recommendation, low-quality evidence). 由于风险预测模型简单且阴性...

JAMA Clinical Guidelines Synopsis March 25, 2019 Management of Patients With Severe Aortic Stenosis With Transcatheter Valve Replacement AbdulRahman Dia, Adam S. Cifu, Atman P. Shah JAMA. 2019;321(15):1527-1528. doi:10.1001/jama.2019.1336 Guideline title 指南标题 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease 2014 AHA/ACC 心脏瓣膜病患者诊治指南的...

Optimization of the treatment with beta-lactam antibiotics in critically ill patients—guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie et Thérapeutique—SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’Anesthésie et Réanimation—SFAR) Guilhaumou et al. Critical Care (2019) 23:104 https://doi.org/10.1186/s13054-019-2378-9 Guidelines 指南 First area. Pharma...

PulmCrit: The surviving sepsis campaign 1-hour bundle is… back? February 12, 2019 by Josh Farkas The surviving sepsis campaign (SSC) has had substantial problems dating back to its inception.  The original backbone of the guidelines was a single-center trial by Rivers, which has largely been debunked.1–4  Initially the SSC was slow to let go of invasive early goal-directed therapy.  The SSC has finally started eliminating older dogma (e.g., ...

Practice | Rapid Recommendations Oxygen therapy for acutely ill medical patients: a clinical practice guideline Reed A C Siemieniuk, Derek K Chu, Lisa Ha-Yeon Kim, et al BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4169 (Published 24 October 2018) Cite this as: BMJ 2018;363:k4169

GUIDELINES Renal replacement therapy: summary of NICE guidance James Gilbert, Kate Lovibond, Andrew Mooney, et al BMJ 2018;363:k4303 doi: 10.1136/bmj.k4303 Indications for starting renal replacement therapy • Consider starting dialysis when indicated by the impact of symptoms of uraemia on daily living, or biochemical measures, or uncontrollable fluid overload, or at an eGFR of around 5-7 mL/min/1.73 m2 if there are no symptoms. [Based on low quality eviden...

Use sepsis bundles, or you’re breaking the (New York) law Sep 28, 2017 In 2013, New York's state government began regulating the care of sepsis. The state has since required its hospitals (and thus its doctors) to adhere to some version of a sepsis protocol that included a "bundle" to be delivered within 3 hours after sepsis recognition: blood cultures before antibiotics; lactate measurement; broad-spectrum antibiotics The Empire State legislature and health departmen...