JAMA Insights  June 26, 2023 Prophylaxis Against Pneumocystis jirovecii Pneumonia in Adults Shiwei Zhou, Samuel L. Aitken JAMA. Published online June 26, 2023. doi:10.1001/jama.2023.9844 Pneumocystis jirovecii is an opportunistic fungal pathogen that causes life-threatening pneumonia in immunocompromised patients. Patients with Pneumocystis pneumonia (PCP) typically present with fever, nonproductive cough, dyspnea, an...

A New Global Definition of Acute Respiratory Distress Syndrome Michael A. Matthay, Yaseen Arabi, Alejandro C. Arroliga, et al Am J Respir Crit Care Med Published July 24, 2023 10.1164/rccm.202303-0558WS Abstract Background Since the 2012 Berlin Definition of the Acute Respiratory Distress Syndrome (ARDS), several developments have supported the need for an expansion of the definition, including the use of high flow nasal oxygen (HFNO), expanding use of p...

JAMA Clinical Guidelines Synopsis  June 17, 2023 Caring for Patients With Acute Respiratory Distress Syndrome: Summary of the 2023 ESICM Practice Guidelines Derek C. Angus, Christopher W. Seymour, Kirsten Bibbins-Domingo JAMA. Published online June 17, 2023. doi:10.1001/jama.2023.6812 Guideline title ESICM Guidelines on Acute Respiratory Distress Syndrome: Definition, Phenotyping and Respiratory Support Strategies Release date Ju...

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7 Domain 6: PEEP and recruitment maneuvers Question 6.1: In patients with ARDS undergoing invasive mechanical ventilation, does ...

Conference Reports and Expert Panel Open Access Published: 16 June 2023 ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies Grasselli, G., Calfee, C.S., Camporota, L. et al. Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07050-7 Domain 1: ARDS definition Domain 2: ARDS phenotyping Question 2.1: How do we define an ARDS sub-phenotype? Based on the currently avai...

GUIDELINES Published: 04 April 2023 ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia Ignacio Martin-Loeches, Antoni Torres, Blin Nagavci, et al Intensive Care Med (2023). https://doi.org/10.1007/s00134-023-07033-8 Question 1: In patients with sCAP, should rapid microbiological techniques be added to current testing of blood and respiratory tract samples? RecommendationsIf the technology is available, we&nb...

Guidelines Open Access Published: 01 March 2023 The European guideline on management of major bleeding and coagulopathy following trauma: sixth edition Rolf Rossaint, Arash Afshari, Bertil Bouillon, et al Crit Care 2023; 27: 80 I. Initial resuscitation and prevention of further bleeding Minimal elapsed time Recommendation 1 We recommend that severely injured patients be transported directly to an appropriate trauma facility (Grade 1B...

JAMA Clinical Guidelines Synopsis  February 16, 2023 Management of Thoracic Aortic Dissection Irbaz Hameed, Adam S. Cifu, Prashanth Vallabhajosyula JAMA. Published online February 16, 2023. doi:10.1001/jama.2023.0265 Guideline titles American Association for Thoracic Surgery Expert Consensus Document: Surgical Treatment of Acute Type A Aortic Dissection; Society of Thoracic Surgeons/American Association for Thoracic Surgery Clinical Prac...

Medical News in Brief  February 8, 2023 Updated COVID-19 Guidance for People Who Are Immunocompromised Emily Harris JAMA. Published online February 8, 2023. doi:10.1001/jama.2023.1176 In late January, the US Food and Drug Administration announced that Evusheld (the combined monoclonal antibodies tixagevimab and cilgavimab) is not currently authorized for emergency use because it’s likely ineffective against more than 90% o...