Research Special Paper Impact of physician assistants on quality of care: rapid review Nicola Cooper, Steven Agius, Kate Freeman, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2025-086358 (Published 03 July 2025)Cite this as: BMJ 2025;390:e086358 Abstract Objective To determine the impact of physician assistants, compared with physicians, on quality of care in the context of an ongoing UK policy review. Design Rapid systematic revie...

Original Investigation  Infectious Diseases Adherence to Quality-of-Care Indicators and Mortality Outcomes in Patients With MRSA Bacteremia: A Post Hoc Analysis of the CAMERA2 Randomized Clinical Trial Russel Lee, Yanan Zhu, Neela J. Rai, et al JAMA Netw Open 2025;8;(7):e2523220. doi:10.1001/jamanetworkopen.2025.23220 Key Points Question  Is clinical trial participation associated with improved adherence to 7 evidence-based quality-of-care...

Research Letter  Statistics and Research Methods Confounder Selection in Observational Studies in High-Impact Medical and Epidemiological Journals Luis C. L. Correia, Rafael F. Mascarenhas, Felipe S. C. De Menezes, et al JAMA Netw Open 2025;8;(7):e2524176. doi:10.1001/jamanetworkopen.2025.24176 Introduction There is growing interest in using observational data and methods to evaluate questions about the causal effects o...

Original Investigation  Infectious Diseases Microbiota Transplantation Among Patients Receiving Long-Term Care: The Sentinel REACT Nonrandomized Clinical Trial Michael H. Woodworth, Ahmed Babiker, Radhika Prakash-Asrani, et al JAMA Netw Open 2025;8;(7):e2522740. doi:10.1001/jamanetworkopen.2025.22740 Key Points Question  Is fecal microbiota transplantation (FMT) acceptable and safe for long-term acute car...

Original Investigation  Public Health Computed Tomographic Screening Intervals for Patients at Moderate Risk of Lung Cancer Koen de Nijs, Harry J. de Koning, Pianpian Cao, et al JAMA Netw Open 2025;8;(7):e2523044. doi:10.1001/jamanetworkopen.2025.23044 Key Points Question  Can the benefits of lung cancer screening be preserved while reducing the burden by adapting the annual screening interval to age, sex...

Original Investigation  Statistics and Research Methods Predictive Modeling of Heterogeneous Treatment Effects in RCTs: A Scoping Review Joe V. Selby, Carolien C. H. M. Maas, Bruce H. Fireman, et al JAMA Netw Open 2025;8;(7):e2522390. doi:10.1001/jamanetworkopen.2025.22390 Key Points Question  How often has the 2020 Predictive Approaches to Treatment Heterogeneity (PATH) Statement been cited in published ...

LATEST ISSUE IN MEMORIAM In Memoriam Rinaldo Bellomo: A RemembranceKellum J. A., Ostermann  M. & Ronco C. Rinaldo Bellomo: relentless architect of modern intensive careForni L. G., Hodgson C. & Prowle J. R. ICU TOOLBOX Editorial From bedside to data and back to bedside: why do we need better data to perform trauma phenotyping and improve trauma care?Gauss T., Bouzat P .& Josse J. The Doppler combined assessment of splanchnic perfusion a...

Original Investigation  Health Informatics Operationalization of Artificial Intelligence Applications in the Intensive Care Unit: A Systematic Review Willemijn E. M. Berkhout, Julia J. van Wijngaarden, Jessica D. Workum, et al JAMA Netw Open 2025;8;(7):e2522866. doi:10.1001/jamanetworkopen.2025.22866 Key Points Question  What is the current state of artificial intelligence (AI) use in intensive care units...

Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL) Mekontso Dessap, A., Ricard, JD., Contou, D. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08002-z Abstract Purpose To determine the dose of melatonin with an optimal pharmacokinetic profile and to test whether this dose reduces the prevalence of deliri...

Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial Voiriot, G., Argaud, L., Cohen, Y. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08014-9 Abstract Purpose Multiplex polymerase chain reaction (mPCR) testing has the potential to rapidly and accurately identify causative microorganisms in patients wi...