ARTICLES| VOLUME 11, ISSUE 8, E567-E579, AUGUST 2024 Efficacy and safety of sovleplenib (HMPL-523) in adult patients with chronic primary immune thrombocytopenia in China (ESLIM-01): a randomised, double-blind, placebo-controlled, phase 3 study Yu Hu, Xiaofan Liu, Hu Zhou, et al Lancet Hematol 2024; 11: E567-E579 Published:June 14, 2024 DOI:https://doi.org/10.1016/S2352-3026(24)00139-X Summary Background Sovleplenib, a novel spleen tyrosine kinase (SY...

Original Investigation  Neurology August 2, 2024 Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis Cornelis N. van Ettekoven, Fabian D. Liechti, Matthijs C. Brouwer, et al JAMA Netw Open. 2024;7(8):e2424802. doi:10.1001/jamanetworkopen.2024.24802 Key Points Question  What is the case fatality ratio (CFR) of bacterial meningitis and ho...

Original Investigation  Surgery August 2, 2024 Comparison of Medical Research Abstracts Written by Surgical Trainees and Senior Surgeons or Generated by Large Language Models Alexis M. Holland, William R. Lorenz, Jack C. Cavanagh, et al JAMA Netw Open. 2024;7(8):e2425373. doi:10.1001/jamanetworkopen.2024.25373 Key Points Question  Can large language models generate convincing medical research...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OPEN ACCESS ~ OriginalTwenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trialWigmore G. J. et al Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis Mølgaard Nielsen F. et al EditorialThe limitations of evidence-based medicine compel the practice of personalized ...

Original Investigation  Surgery August 2, 2024 Surgical Repair vs Splenectomy in Patients With Severe Traumatic Spleen Injuries Dominik A. Jakob, Martin Müller, Apostolos Kolitsas, et al JAMA Netw Open. 2024;7(8):e2425300. doi:10.1001/jamanetworkopen.2024.25300 Key Points Question  Is splenic repair associated with better outcomes compared with splenectomy in patients with traumatic splenic i...

Original Investigation  June 27, 2024 A More Selective vs a Standard Risk-Stratified, Heparin-Based, Obstetric Thromboprophylaxis Protocol Macie L. Champion, Christina T. Blanchard, Michelle Y. Lu, et al JAMA. 2024;332(4):310-317. doi:10.1001/jama.2024.8684 Key Points Question  Among patients with increased risk of postpartum venous thromboembolism, does a more selective protocol for initiating postpartum...

Original Investigation  July 31, 2024 Venous Thromboembolism Prophylaxis in High-Risk Pediatric Trauma Patients Amanda B. Witte, Kyle Van Arendonk, Carisa Bergner, et al JAMA Surg. Published online July 31, 2024. doi:10.1001/jamasurg.2024.2487 Key Points Question  Does the application of high-risk guidelines allow for safe and appropriate administration of venous thromboembolism (VTE) prophylaxi...

Research Personal protective effect of wearing surgical face masks in public spaces on self-reported respiratory symptoms in adults: pragmatic randomised superiority trial Runar Barstad Solberg, Atle Fretheim, Ingeborg Hess Elgersma, et ak BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2023-078918 (Published 24 July 2024) Cite this as: BMJ 2024;386:e078918 Abstract Objective To evaluate the personal protective effects of wearing versus not wearing s...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalThrombolysis before venoarterial ECMO for high-risk pulmonary embolism: a retrospective cohort studyLevy D. et al Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trialFreund Y. et al OPEN ACCESS ~ OriginalStandardised and automated assessment of head computed tomography reliably predicts poor functional outcome aft...

Effect of the 1-h bundle on mortality in patients with suspected sepsis in the emergency department: a stepped wedge cluster randomized clinical trial Freund, Y., de Abreu, M.C., Lebal, S. et al. Intensive Care Med 50, 1086–1095 (2024). https://doi.org/10.1007/s00134-024-07509-1 Abstract Purpose The efficacy of the 1-h bundle for emergency department (ED) patients with suspected sepsis, which includes lactate measurement, blood culture, broad-spectrum an...