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2025年02月12日 时讯速递, 进展交流 [Clin Infect Dis发表论文]:非呼吸机相关的医院获得性肺炎患者院内死亡的可预防性已关闭评论

JOURNAL ARTICLE

Preventability of Hospital Deaths in Patients With Non-Ventilator Hospital-Acquired Pneumonia

Alexander M Tatara,  Anna Apostolopoulou,  Anna A Agan,  et al

Clinical Infectious Diseases 2024; 79: 1269-1276

https://doi.org/10.1093/cid/ciae418

Abstract

Background

Crude and adjusted mortality rates for patients with non-ventilator hospital-acquired pneumonia (NV-HAP) are among the highest of all healthcare-associated infections, leading to calls for greater prevention. Patients prone to NV-HAP, however, tend to be severely ill at baseline, making it unclear whether their high mortality rates are due to NV-HAP, their underlying conditions, or both.

Methods

Two infectious disease physicians conducted detailed medical record reviews on 150 randomly selected adults from 4 hospitals who died in-hospital following an NV-HAP event between April 2016 and May 2021. Reviewers abstracted risk factors, estimated the preventability of NV-HAP, identified causes of death, and adjudicated the preventability of death.

Results

The patients’ median age was 69.3 (IQR, 60.7–77.4) years and 43.3% were female. Comorbidities were common: 57% had cancer, 30% chronic kidney disease, 29% chronic lung disease, and 27% had heart failure. At least 1 hospice-eligible condition was present before NV-HAP in 54% and “Do Not Resuscitate” orders in 24%. Most (99%) had difficult-to-modify NV-HAP risk factors: 76% altered mental status, 35% dysphagia, and 27% nasogastric/orogastric tubes. NV-HAP was deemed possibly or probably preventable in 21% and hospital death likely or very likely preventable in 8.6%.

Conclusions

Most patients who die following NV-HAP have multiple, severe underlying comorbidities and difficult-to-modify risk factors for NV-HAP. Only 1 in 5 NV-HAPs that culminated in death and 1 in 12 deaths following NV-HAP were judged potentially preventable. This does not diminish the importance of NV-HAP prevention programs but informs expectations about the potential magnitude of their impact on hospital deaths.

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