Special Communication  Health Informatics January 3, 2025 Digital Health Technology Research Funded by the National Institutes of Health Pablo Cure, Thomas Radman, Jaime Mihoko Doyle, et al JAMA Netw Open. 2025;8(1):e2452976. doi:10.1001/jamanetworkopen.2024.52976 Abstract Importance  Digital health in biomedical research and its expanding list of potential clinical applications are rapidly e...

Original Investigation  Pulmonary Medicine January 3, 2025 Factors in Initial Anticoagulation Choice in Hospitalized Patients With Pulmonary Embolism William B. Stubblefield, Ron Helderman, Natalie Strokes, et al JAMA Netw Open. 2025;8(1):e2452877. doi:10.1001/jamanetworkopen.2024.52877 Key Points Question  What are factors associated with initial anticoagulation choice in hospitalized patien...

Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis Huseyin Naci, Peter Murphy, Beth Woods, et al Lancet 2025; 405: 50-60 Published Online December 12, 2024https://doi.org/10.1016/S0140-6736(24)02352-3 Summary Background Health systems experience difficult trade-offs when paying for new drugs. In England, funding recommendations by the National Institu...

RESEARCH ARTICLE COMPUTER SCIENCES Promotional language and the adoption of innovative ideas in science Hao Peng, Huilian Sophie Qiu, Henrik Barslund Fosse, et al PNAS 2024: 121 (25); e2320066121 Significance Using three longitudinal samples of funded and unfunded grant applications from three of the world’s largest funders—the NIH, the NSF, and the Novo Nordisk Foundation—we find that the percentage of promotional language in a grant proposal is associa...

ORIGINAL ARTICLE Highly Pathogenic Avian Influenza A(H5N1) Virus Infections in Humans Shikha Garg, Katie Reinhart, Alexia Couture, et al N Engl J Med Published December 31, 2024 Abstract BACKGROUND Highly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry in the United States, with sporadic human cases. We describe characteristics of human A(H5N1) cases identified from March through October 2024 in the ...

ONLINE FIRST (FREE ACCESS) ARTIFICIAL INTELLIGENCE IN ICU TOPICAL COLLECTION Editorial Does artificial intelligence close gaps in clinical pharmacology in the ICU? Gijsen M. and De Waele J. J. What if we do, but what if we don’t? The opportunity cost of artificial intelligence hesitancy in the intensive care unit Spencer E-J, Economou-Zavlanos N. J. and van Genderen M. E. The role of artificial intelligence in life-sustaining treatment decisions: curr...

Research Letter  December 30, 2024 Antibody Response to Respiratory Syncytial Virus Vaccination in Immunocompromised Persons Andrew H. Karaba, Camille Hage, Isabella Sengsouk, et al JAMA. Published online December 30, 2024. doi:10.1001/jama.2024.25395 Respiratory syncytial virus (RSV) infection causes high morbidity in immunocompromised persons.1Novel prefusion F (preF)–containing RSV vaccines showed 13- to ...

ORIGINAL ARTICLE Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy Marianna Fontana, John L. Berk, Julian D. Gillmore, et al N Engl J Med 2025;392:33-44 DOI: 10.1056/NEJMoa2409134 Abstract BACKGROUND Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, fatal disease. Vutrisiran, a subcutaneously administered RNA interference therapeutic agent, inhibits the production of hepatic transthyretin. 转甲状腺素...

Research Letter  November 11, 2024 Online Retailer Nonadherence to Age Verification, Shipping, and Flavor Restrictions on E-Cigarettes Raquel M. Harati, Shannon E. Ellis, Nora Satybaldiyeva, et al JAMA. 2024;332(24):2113-2114. doi:10.1001/jama.2024.21597 To curtail youth access to vaping products, the 2020 Preventing Online Sales of E-Cigarettes to Children Act implemented a ban on the use of the United States Postal ...

Original Investigation  December 30, 2024 Pain Coping Skills Training for Patients Receiving Hemodialysis: The HOPE Consortium Randomized Clinical Trial Laura M. Dember, Jesse Y. Hsu, Rajnish Mehrotra, et al JAMA Intern Med. Published online December 30, 2024. doi:10.1001/jamainternmed.2024.7140 Key Points Question  Does pain coping skills training (PCST), a cognitive behavioral intervention, re...