Original Investigation  January 13, 2025 Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis Ya Gao, Yunli Zhao, Ming Liu, et al JAMA Intern Med. 2025;185(3):293-301. doi:10.1001/jamainternmed.2024.7193 Key Points Question  What is the optimal antiviral drug in the treatment of patients with nonsevere influenza virus infection? Findings  I...

Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial Francis Couturaud, Jeannot Schmidt, Olivier Sanchez, et al Lancet 2025; 405: 725-735 Summary Background In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has ...

Research Letter  Physician Work Environment and Well-Being February 24, 2025 Trends in Physician Electronic Health Record Time and Message Volume A Jay Holmgren, Nate C. Apathy, Christine A. Sinsky, et al JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8138 Physician work is increasingly centered around the electronic health record (EHR), which consumes nearly 50% of sc...

Original Investigation  Physician Work Environment and Well-Being February 24, 2025 Mortality Among US Physicians and Other Health Care Workers Vishal R. Patel, Michael Liu, Christopher M. Worsham, et al JAMA Intern Med. Published online February 24, 2025. doi:10.1001/jamainternmed.2024.8432 Key Points Question  How do mortality rates differ by sex, race, and ethnicity among physicians and ot...

The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa The African Critical Illness Outcomes Study (ACIOS) Investigators Lancet 2025; 405: 715-724 Summary Background Critical illness represents a major global health-care burden and critical care is an essential component of hospital care. There are few data describing the prevalence, treatment, and outcomes of critically ill patients in Afri...

Research Discrepancies in neglected tropical diseases burden estimates in China: comparative study of real-world data and Global Burden of Disease 2021 data (2004-2020) Guo-Jing Yang, Han-Qi Ouyang, Zi-Yu Zhao, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-080969 (Published 18 February 2025)Cite this as: BMJ 2025;388:e080969 Abstract Objectives To assess the discrepancies between real-world data and the Global Burden of Disease (GBD) 2021 e...

Research Effect of high flow nasal cannula oxygenation on incidence of hypoxia during sedated gastrointestinal endoscopy in patients with obesity: multicentre randomised controlled trial Leilei Wang, Yuanyuan Zhang, Dan Han, et al BMJ 2025; 388 doi: https://doi.org/10.1136/bmj-2024-080795 (Published 11 February 2025)Cite this as: BMJ 2025;388:e080795 Abstract Objective To determine whether high flow nasal cannula (HFNC) oxygenation can reduce the incid...

Research Letter  February 17, 2025 Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals Daniel Shepshelovich, Dafna Yahav, Danielle R. Rome, et al JAMA Intern Med. Published online February 17, 2025. doi:10.1001/jamainternmed.2024.7694 The extent of heterogeneity in end points reported by randomized clinical trials (RCTs) of atherosc...

Research Letter  Health Policy February 19, 2025 Health Care Staffing Shortages and Potential National Hospital Bed Shortage Richard K. Leuchter, Benjo A. Delarmente, Sitaram Vangala, et al JAMA Netw Open. 2025;8(2):e2460645. doi:10.1001/jamanetworkopen.2024.60645 Introduction Between August 2020 and April 2024, US hospitals were mandated to report weekly occupancy to the Department of Health and Human...

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection Dimitri M Drekonja, Aasma Shaukat, Yuan Huang, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 52–60, https://doi.org/10.1093/cid/ciae467 Abstract Background Clostridioides difficile infection (CDI) is the most common cause of healthcare–associated in...