Original Investigation  January 27, 2025 Termination of Resuscitation Rules for In-Hospital Cardiac Arrest Mathias J. Holmberg, Asger Granfeldt, Ari Moskowitz, et al JAMA Intern Med. Published online January 27, 2025. doi:10.1001/jamainternmed.2024.7814 Key Points Question  Can a clinical decision rule guide termination of resuscitation efforts during in-hospital cardiac arrest? Findings ...

Original Investigation  January 27, 2025 Negative Pressure Dressings to Prevent Surgical Site Infection After Emergency Laparotomy: The SUNRRISE Randomized Clinical Trial SUNRRISE Trial Study Group JAMA. Published online January 27, 2025. doi:10.1001/jama.2024.24764 Key Points Question  Among patients undergoing emergency laparotomy, is there a difference in surgical site infection (SSI) rates when the wound is treated with ...

Original Investigation  Diabetes and Endocrinology January 21, 2025 Use of Albumin-Adjusted Calcium Measurements in Clinical Practice Noémie Desgagnés, James A. King, Gregory A. Kline, et al JAMA Netw Open. 2025;8(1):e2455251. doi:10.1001/jamanetworkopen.2024.55251 Key Points Question  How accurate are the calcium adjustment formulas that are used in clinical practice? Findings  ...

Original Investigation  January 15, 2025 Association Between Surgeon Stress and Major Surgical Complications Jake Awtry, Sarah Skinner, Stephanie Polazzi, et al JAMA Surg. Published online January 15, 2025. doi:10.1001/jamasurg.2024.6072 Key Points Question  Is surgeon physiological stress, as deduced from the sympathovagal balance measured via heart rate variability analysis, associated with pa...

Research Letter  January 2, 2025 Knowledge and Worry Following Review of Standard vs Patient-Centered Pathology Reports Cathryn J. Lapedis, Sophia R. Kurnot, Sarah E. Bergholtz, et al JAMA. Published online January 2, 2025. doi:10.1001/jama.2024.25461 The immediate release of test results to patients via patient portals is required.1,2 Unfortunately, pathology reports contain complex medical terminology...

Original Investigation  Caring for the Critically Ill Patient March 18, 2025 Optimal Vasopressin Initiation in Septic Shock: The OVISS Reinforcement Learning Study Alexandre Kalimouttou, Jason N. Kennedy, Jean Feng, et al JAMA. Published online March 18, 2025. doi:10.1001/jama.2025.3046 Key Points Question  Does a reinforcement learning model identify the optimal initiation rule for vasopress...

Original Investigation  Caring for the Critically Ill Patient March 18, 2025 Inhaled Sedation in Acute Respiratory Distress Syndrome: The SESAR Randomized Clinical Trial Matthieu Jabaudon, Jean-Pierre Quenot, Julio Badie, et al JAMA. Published online March 18, 2025. doi:10.1001/jama.2025.3169 Key Points Question  Is a strategy of inhaled sedation with sevoflurane safe and associated with improved clinical outcomes in patients ...

Original Investigation  Infectious Diseases January 15, 2025 Blood Culture Use in Medical and Surgical Intensive Care Units and Wards Valeria Fabre, Yea-Jen Hsu, Karen C. Carroll, et al JAMA Netw Open. 2025;8(1):e2454738. doi:10.1001/jamanetworkopen.2024.54738 Key Points Question  What is the blood culture use rate of medical and medical-surgical intensive care units (ICUs) and wards in the U...

Original Investigation  January 15, 2025 Palliative Care Initiated in the Emergency Department: A Cluster Randomized Clinical Trial Corita R. Grudzen, Nina Siman, Allison M. Cuthel, et al JAMA. Published online January 15, 2025. doi:10.1001/jama.2024.23696 Key Points Question  What is the effect of a multicomponent intervention to initiate palliative care in the emergency department on hospital ...

Original Investigation  January 13, 2025 Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis Ya Gao, Yunli Zhao, Ming Liu, et al JAMA Intern Med. Published online January 13, 2025. doi:10.1001/jamainternmed.2024.7193 Key Points Question  What is the optimal antiviral drug in the treatment of patients with nonsevere influenza virus infection? ...