Original Research Quality of Human Expert versus Large Language Model Generated Multiple Choice Questions in the Field of Mechanical Ventilation Sami Safadi, Roxana Amirahmadi, Abdulhakim Tlimat, et al Chest Available online 18 July 2025 https://doi.org/10.1016/j.chest.2025.07.005 Abstract Background Mechanical ventilation (MV) is a critical competency in critical care training, yet standardized methods for assessing MV-related knowledge are lacking. ...

Critical Care: Original Research Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Kevin P. Seitz, Bradley D. Lloyd, Li Wang, et al Chest Available online 4 April 2025 https://doi.org/10.1016/j.chest.2025.03.024 Background Whether the choice of ventilator mode affects outcomes for critically ill patients is unknown. Research Question What are the effects of 3 common ventilator modes (volume cont...

CRITICAL CARE: ORIGINAL RESEARCH Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial Edward T. Qian, Ryan M. Brown, Karen E. Jackson, et al Chest 2025; 168: 336-345 Abstract Background Balanced crystalloid solutions may improve clinical outcomes compared with saline for some critically ill adults, but it is unclear whether differences in composition between balanced crystalloid solutions affect outcomes. Research Question Does ...

Original Investigation  Occupational Health Smartwatch Use and Physician Well-Being: A Randomized Clinical Trial Liselotte N. Dyrbye, Colin P. West, Angelina R. Wilton, et al JAMA Netw Open Published Online: August 18, 2025 2025;8;(8):e2527275. doi:10.1001/jamanetworkopen.2025.27275 Key Points Question  Does wearing a smartwatch and having access to its physiological data (eg, sleep, ste...

Original Investigation  Health Policy Variation, Overlap, and Stability in Defining Safety Net Hospitals Paula Chatterjee, Joshua M. Liao, Kano Amagai, et al JAMA Netw Open 2025;8;(7):e2523923. doi:10.1001/jamanetworkopen.2025.23923 Key Points Question  To what extent do different definitions for safety net hospitals overlap, change over time, and represent similar types of facilities? Findings &n...

Original Investigation  Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality: A Randomized Clinical Trial Stephanie Parks Taylor, Tara Eaton, Aleta Rios, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3699 Key Points Question  Does a multicomponent, navigator-led sepsis transition and recovery (STAR) progr...

Research Letter  Trends in Utilization of Microaxial Flow Pump and Intra-Aortic Balloon Pump Across 3 Countries Dennis T. Ko, Sharon Ayayo, Amitava Banerjee, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3881 Rising health care spending is threatening the sustainability of health systems in many high-income countries.1While health technology assessment (HTA) is used ...

Original Investigation  Global Burden of Disease Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021 GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators JAMA Neurol 2025;82;(8):765-787. doi:10.1001/jamaneurol.2025.1522 Key Points Question  What is the global burden of nontraumatic subarachnoid hemorrhage (SAH)? Findings  Results of this cross-...

Original Investigation  Prophylactic Antibiotics for Upper Gastrointestinal Bleeding in Patients With Cirrhosis: A Systematic Review and Bayesian Meta-Analysis Connor Prosty, Dean Noutsios, Laurie-Rose Dubé, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3832 Key Points Question  Are shorter durations (including 0 days) noninferior to longer durations of antib...

Original Investigation  Global Scaling of a Surgical Infection Prevention Program to 5 Low-Resource Countries Writing Group for the Clean Cut Investigators Group JAMA Surg Published Online: August 13, 2025 doi: 10.1001/jamasurg.2025.2790 Key Points Question  Can a previously validated quality improvement program shown to be effective in preventing surgical infections in Ethiopia be scaled to other low-income settings through...