Original Investigation  Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial Bernd Saugel, Agnes S. Meidert, Frank M. Brunkhorst, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.17235 Key Points Question  Does individualized perioperative blood pressure management based on preoperative n...

Original Investigation  Pacific Coast Surgical Association Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures: A Randomized Clinical Trial Jeffry Nahmias, Stephen Stopenski, Mallory Jebbia, et al JAMA Surg 2025;160;(10):1047-1056. doi:10.1001/jamasurg.2025.3221 Key Points Question  Does the addition of dexmedetomidine to standard multimodal analgesia reduce opioid consumpt...

Articles The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Cancer Collaborators Lancet 2025; 406: 1565-1586 Summary Background Cancer is a leading cause of death globally. Accurate cancer burden information is crucial for policy planning, but many countries do not have up-to-date cancer surveillance data. To inform global cancer-control effort...

Original Investigation  Implementing a Patient-Centered Education Bundle to Improve Venous Thromboembolism Prevention Elliott R. Haut, Oluwafemi P. Owodunni, Dauryne L. Shaffer, et al JAMA Surg Published Online: October 8, 2025 doi: 10.1001/jamasurg.2025.4136 Key Points Question  Does a comprehensive intervention to address missed doses of venous thromboembolism (VTE) prophylaxis reduce missed d...

Research Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial  Perry Wilson, Melissa Martin, Yu Yamamoto, et al BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.m4786 (Published 18 January 2021)Cite this as: BMJ 2021;372:m4786 Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injur...

Research Letter  Regulatory and Clinical Outcomes of Nononcology Accelerated Approvals Ian T. T. Liu, Gemma Reynolds, Aaron S. Kesselheim, et al JAMA 2025;334;(13):1194-1196. doi:10.1001/jama.2025.10726 The US Food and Drug Administration (FDA) accelerated approval pathway expedites drug approvals based on changes to surrogate or intermediate measures only “reasonably likely” to predict clinical benefit. Therapies grante...

ORIGINAL ARTICLE Impact of Artificial Intelligence–Based Triage Decision Support on Emergency Department Care R. Andrew Taylor, Chris Chmura, Jeremiah Hinson, et al Published February 27, 2025 NEJM AI 2025;2(3) DOI: 10.1056/AIoa2400296 Abstract BACKGROUND Emergency department (ED) triage methods are limited in their ability to risk-stratify patients and identify critical illnesses. Our objective was to examine t...

ORIGINAL ARTICLE Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans Miao Cai, Yan Xie, Ziyad Al-Aly N Engl J Med Published October 8, 2025 DOI: 10.1056/NEJMoa2510226 Abstract BACKGROUND Amid the declining clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and diminishing public uptake of annual coronavirus disease 2019 (Covid-19) vaccines, contemporary evidence on vaccine effecti...

Research Letter  Revisiting Minimum Case Volume Recommendations for Complex Surgery in Contemporary Practice Akash Kartik, Zhi Ven Fong, Chee-Chee Stucky, et al JAMA Published Online: October 8, 2025 doi: 10.1001/jama.2025.17274 The volume-outcome relationship informs policies guiding complex cancer surgery—historically, higher case volumes were associated with better postoperative mortality.1 Consequen...

ORIGINAL ARTICLE Hypertonic Saline or Carbocisteine in Bronchiectasis Judy M. Bradley, Brenda O’Neill, Daniel F. McAuley, et al N Engl J Med Published September 28, 2025 DOI: 10.1056/NEJMoa2510095 Abstract BACKGROUND Bronchiectasis guidelines are inconsistent with regard to the effectiveness of mucoactive agents, and their use varies geographically. Large trials are needed to assess safety and effectiveness. METHODS For this open-label, randomiz...