CLINICAL INVESTIGATION Phenylephrine Vs. Norepinephrine on the Renin–Angiotensin–Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial Chen, Junda; Wang, Xinghe; Yin, Tianyu; et al Crit Care Med 2025; 53(12): e2629-e2641 DOI: 10.1097/CCM.0000000000006912 Objectives:  This study aimed to explore how phenylephrine (PE) and norepinephrine (NE) affect renin–angiotensin–aldosterone system (RA...

Original Investigation  Pediatrics Hospital Admissions After Early-Onset Neonatal Bacterial Infection Management Guidelines in France Léna Paucard, Bérénice Varga, Elsa Kermorvant-Duchemin, et al JAMA Netw Open 2025;8;(11):e2545436. doi:10.1001/jamanetworkopen.2025.45436 Key Points Question  Were the 2017 French guidelines on early-onset neonatal bacterial infections (EONIs), which replaced systematic mic...

Original Investigation  Changes in Health Care Use and Outcomes After Turnover in Primary Care Adrienne H. Sabety, Anupam B. Jena, Michael L. Barnett JAMA Intern Med 2021;181;(2):186-194 doi:10.1001/jamainternmed.2020.6288 Key Points Question  What is the association of health care use and outcomes with the loss of a primary care physician? Findings  In this cohort study of 359 470 Medicare beneficiari...

ORIGINAL ARTICLE Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis Charmaine E. Lok, Michael Farkouh, Brenda R. Hemmelgarn, et al N Engl J Med Published November 7, 2025 DOI: 10.1056/NEJMoa2513032 Abstract BACKGROUND Cardiovascular disease is the leading cause of death in patients receiving hemodialysis, yet effective preventive therapies remain limited. Supplementation with n−3 polyunsaturated fatty acids, especial...

CRITICAL CARE: ORIGINAL RESEARCH Oxygen Saturation Targets and Neurologic Outcomes Following Cardiac Arrest: A Secondary Analysis of the Pragmatic Investigation of Optimal Oxygen Targets Trial Stephanie C. DeMasi, Alexander T. Clark, Amelia L. Muhs, et al Chest 2025; 168: 1131-1140 DOI: 10.1016/j.chest.2025.04.027 External Link Abstract Background More than 600,000 adults in the United States experience an out-of-hospital or in-hospital cardiac arrest...

ORIGINAL ARTICLE A Multicomponent Intervention to Improve Maternal Infection Outcomes David Lissauer, Luis Gadama, Catriona Waitt, et al N Engl J Med Published November 19, 2025 Abstract BACKGROUND Maternal infection and sepsis are major causes of maternal death and severe illness worldwide, particularly in low- and middle-income countries. Inconsistent implementation of evidence-based recommendations for infection prevention and management and delays in...

Articles Duration of the serological response and effectiveness of the inactivated influenza vaccine in healthy adults aged 18–65 years: a systematic review and meta-analysis Joshua Nazareth, Neyme Veli, Daniel Pan, et al Lancet Microbe 2025; 6: 101136 https://doi.org/10.1016/j.lanmic.2025.101136 Summary Background The protection provided by the inactivated influenza vaccine (IIV) in adults can wane during a single influenza season. We aimed to assess...

Critical Care: Original Research Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT) David J. Gagnon, Kristin M. Burkholder, Alexandra J. Weissman, et al Chest 2025 Available online 28 August 2025 https://doi.org/10.1016/j.chest.2025.08.007 Background Antibiotic prophylaxis following out-of-hospital cardiac arrest (OHCA) reduces ear...

Articles Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study Adela Alcolea-Medina, Luke B Snell, Gul Humayun, et al Lancet Microbe 2025; 6: 101174 https://doi.org/10.1016/j.lanmic.2025.101174 Summary Background Most clinical metagenomic studies do not provide rapid results, detect pathogens from all microbial kingdoms, or measure clinical impacts. ...

Articles The aetiology and prevalence of preoperative anaemia in patients undergoing major surgery (ALICE): an international, prospective, observational cohort study Suma Choorapoikayil, David M Baron, Donat R Spahn, et al Lancet Global Health 2025; 13: e2041-e2050 https://doi.org/10.1016/S2214-109X(25)00320-1   Summary Background Preoperative anaemia is a major risk factor for perioperative morbidity. Because iron deficiency is widely assumed to b...