Original Investigation  Anesthesiology Guideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery Amit Bardia, MBBS, Hung-Mo Lin, Xiwen Zhao, et al JAMA Netw Open 2026;9;(2):e2559349. doi:10.1001/jamanetworkopen.2025.59349 Key Points Question  What is the association of adherence to Infectious Diseases Society of America (IDSA) perioperative antibiotic prophylaxis ...

ONLINE FIRST (FREE ACCESS) PERIOPERATIVE CARE IN THE ICU What's New in Intensive Care The perioperative brain: navigating neurological risks in non-neurosurgical patientsBadenes, R., Romero-Garcia, N. & Marshall, T.J. PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Physiological effects of prone positioning during invasive mechanical ventilation: beyond PaO2Cornejo, R., Papazian, L. & Martin Delgado, M.C. LATEST ARTICLES Original ...

Original Investigation  Infectious Diseases Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis Bertrand Drugeon, Gabor Mihala, Jessica Schults, et al JAMA Netw Open 2026;9;(2):e2558954. doi:10.1001/jamanetworkopen.2025.58954 Key Points Question  What concentration and formulation of chlorhexidine or povidone-iodine is associated with the lo...

Research Letter  Pediatrics Availability of Higher-Level Neonatal Care in Rural and Urban US Hospitals, 2010-2022 Katy B. Kozhimannil, Emily C. Sheffield, Clara E. Busse, et al JAMA Netw Open 2026;9;(2):e2559680. doi:10.1001/jamanetworkopen.2025.59680 Introduction Infant mortality is elevated for residents of rural US communities, in which access to childbirth care has been declining.1,2 Infants with high-acuity cl...

Original Investigation  Critical Care Medicine Physician Variation in Early Sepsis Management Ithan D. Peltan, Danielle Groat, Jorie Butler, et al JAMA Netw Open 2026;9;(2):e2556945. doi:10.1001/jamanetworkopen.2025.56945 Key Points Question  Are sepsis treatment practice patterns characterized by faster antimicrobial initiation associated with increased overtreatment, and what are their mechanisms? Fi...

Article Health outcomes according to severity of acute kidney injury at ICU admission: a population-based cohort study Hundemer, G.L., Dumicho, A.Y., Knoll, G.A. et al. Intensive Care Med(2026). Published: 05 February 2026 https://doi.org/10.1007/s00134-026-08317-5 Abstract Purpose The presence and severity of acute kidney injury (AKI) upon ICU admission provides important short- and long-term prognostic information. Existing reports have been limited...

Articles Recombinant factor VIIa versus placebo for spontaneous intracerebral haemorrhage within 2 h of symptom onset (FASTEST): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial Joseph P Broderick, Andrew M Naidech, Jordan J Elm, et al Lancet Available online 4 February 2026 https://doi.org/10.1016/S0140-6736(26)00097-8 Summary Background Recombinant factor VIIa has been shown to slow bleeding in patients with intracerebral h...

Article The comparison of circuit lifespan between integration and separation approach in extracorporeal membrane oxygenation patients requiring continuous renal replacement therapy support: a randomized controlled trial (E-CRRT Trial) Tangjitaree, P., Thanapongsatorn, P., Sinjira, T. et al. Intensive Care Med (2026). https://doi.org/10.1007/s00134-026-08302-y Abstract Background The estimated incidence of acute kidney injury requiring renal replacement ...

HUMANITIES: ORIGINAL RESEARCHVolume 169, Issue 2P486-495February 2026 Post-Intensive Care Syndrome Awareness and Communication: Surveys of ICU Providers and Patients Mark L. Rolfsen, Matthew F. Mart, Hannah Kieffer, et al Chest 2026; 169: 486-495 DOI: 10.1016/j.chest.2025.08.048 Abstract Background Survivors of critical illness often experience new or worsening impairments in various domains of health after discharge, collectively referred to as post-...

JOURNAL ARTICLE EDITOR'S CHOICE Retreatment With Nirmatrelvir/Ritonavir Following Return of COVID-19 Symptoms and SARS-CoV-2 Positivity Wuyan Zhang, Steven G Terra, Edward Alan Weinstein, et al Clinical Infectious Diseases, Volume 82, Issue 1, 15 January 2026, Pages e33–e40, https://doi.org/10.1093/cid/ciaf548 Abstract Background Rebound of coronavirus disease 2019 (COVID-19) is defined as return of symptoms and/or viral positivity af...