Guideline-Driven LLM Boosts Sepsis Mortality Prediction  In Sepsis Tue, 2 Dec 2025 Sepsis remains a major cause of in-hospital mortality worldwide and places a substantial burden on intensive care units and healthcare systems. Despite regular updates to clinical guidance and advances in treatment, outcomes for many patients remain poor and early identification of those at highest risk continues to be challenging. Conventional risk scores and tradi...

Original Investigation  Statistics and Research Methods Design and Implementation of Observational Studies Emulating a Target Trial Yan Ren, Yulong Jia, Lingyan Liu, et al JAMA Netw Open 2026;9;(2):e2558262. doi:10.1001/jamanetworkopen.2025.58262 Key Points Question  In which clinical scenarios has target trial emulation (TTE) been applied, and how well do TTE studies adhere to key principles of target tr...

Original Investigation  Critical Care Medicine Albumin Replacement Therapy in Septic Shock: A Randomized Clinical Trial Yasser Sakr, Axel Nierhaus, Ulrike Schumacher, et al JAMA Netw Open 2026;9;(2):e2559297. doi:10.1001/jamanetworkopen.2025.59297 Key Points Question  Can the reported potential mortality reduction by albumin replacement in septic shock be confirmed in a randomized clinical trial? Findi...

Original Investigation  Emergency Medical Individual Clinician Volume and Mortality in Trauma Patients Jamison Beiriger, Christian Martin-Gill, David S. Silver, et al JAMA Surg Published Online: February 18, 2026 doi: 10.1001/jamasurg.2025.6741 Key Points Question  Is the patient volume of individual emergency medical services (EMS) clinicians associated with trauma patient outcomes? Findings...

Research Letter  Pediatrics Clinical Decision Support for Antibiotic Prescribing Duration in Children With Acute Otitis Media Matt Mason, Sara Ruth Slovin, Arezoo Zomorrodi, et al JAMA Netw Open 2026;9;(2):e2560066. doi:10.1001/jamanetworkopen.2025.60066 Introduction Acute otitis media (AOM) is the most common indication for antibiotics in children.1 The American Academy of Pediatrics recommends 10 days of the...

Original Investigation  Nutrition, Obesity, and Exercise Leisure-Time Physical Activity and Cancer Mortality Among Cancer Survivors Erika Rees-Punia, Lauren R. Teras, Christina C. Newton, et al JAMA Netw Open 2026;9;(2):e2556971. doi:10.1001/jamanetworkopen.2025.56971 Key Points Question  Is engagement in physical activity after a cancer diagnosis associated with longer survival among individuals with a h...

Original Investigation  Anesthesiology Guideline Adherence of Perioperative Antibiotics and Surgical Site Infections in Noncardiac Surgery Amit Bardia, MBBS, Hung-Mo Lin, Xiwen Zhao, et al JAMA Netw Open 2026;9;(2):e2559349. doi:10.1001/jamanetworkopen.2025.59349 Key Points Question  What is the association of adherence to Infectious Diseases Society of America (IDSA) perioperative antibiotic prophylaxis ...

ONLINE FIRST (FREE ACCESS) PERIOPERATIVE CARE IN THE ICU What's New in Intensive Care The perioperative brain: navigating neurological risks in non-neurosurgical patientsBadenes, R., Romero-Garcia, N. & Marshall, T.J. PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Physiological effects of prone positioning during invasive mechanical ventilation: beyond PaO2Cornejo, R., Papazian, L. & Martin Delgado, M.C. LATEST ARTICLES Original ...

Original Investigation  Infectious Diseases Chlorhexidine vs Povidone-Iodine and Incidence of Catheter-Related Infections: A Systematic Review and Meta-Analysis Bertrand Drugeon, Gabor Mihala, Jessica Schults, et al JAMA Netw Open 2026;9;(2):e2558954. doi:10.1001/jamanetworkopen.2025.58954 Key Points Question  What concentration and formulation of chlorhexidine or povidone-iodine is associated with the lo...

Research Letter  Pediatrics Availability of Higher-Level Neonatal Care in Rural and Urban US Hospitals, 2010-2022 Katy B. Kozhimannil, Emily C. Sheffield, Clara E. Busse, et al JAMA Netw Open 2026;9;(2):e2559680. doi:10.1001/jamanetworkopen.2025.59680 Introduction Infant mortality is elevated for residents of rural US communities, in which access to childbirth care has been declining.1,2 Infants with high-acuity cl...