Original Investigation  Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial Himanshu Narang, Daizee Talukdar, Bipul Kumar, et al JAMA Intern Med Published Online: April 20, 2026 doi: 10.1001/jamainternmed.2026.0655 Key Points Question  Is fecal microbiota transplant (FMT) effective in achieving gut decolonization of...

Original Investigation  Fast Antimicrobial Susceptibility Testing for Gram-Negative Bacteremia: The FAST Randomized Clinical Trial Ritu Banerjee, Lauren Komarow, Yixuan Li, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2026.5487 Key Points Question  Does use of rapid antimicrobial susceptibility testing directly from blood culture bottles positive for gram-negative bacteria impro...

Original Investigation  Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults Timothy J. Savage, Anne M. Butler, Matthew P. Kronman, et al JAMA Published Online: April 18, 2026 doi: 10.1001/jama.2025.26902 Key Points Question  For acute sinusitis in adults younger than 65 years, is standard-dose amoxicillin-clavulanate associated with different risks of treatment failure and adver...

Original Investigation  Gastroenterology and Hepatology Computer-Assisted Colonoscopy in High–Adenoma Detection Rate Settings in a High-Risk Population: A Randomized Clinical Trial Wen-Feng Hsu, Chen-Ya Kuo, Hsu-Heng Yen, et al JAMA Netw Open 2026;9;(4):e264881. doi:10.1001/jamanetworkopen.2026.4881 Key Points Question  Does the use of computer-aided detection (CAD) during colonoscopy improve adenoma dete...

Original Investigation  Surgery β-Lactam vs Non–β-Lactam Prophylaxis in Elective Colorectal Surgery Curtis D. Collins, Eric Hartsfield, Robert K. Cleary, et al JAMA Netw Open 2026;9;(4):e266708. doi:10.1001/jamanetworkopen.2026.6708 Key Points Question  Are surgical prophylaxis regimens containing β-lactam antibiotics associated with lower surgical site infections (SSIs) compared with non–β-lactam alternative regimens in patients undergoin...

Original Investigation  Health Informatics Large Language Model Performance and Clinical Reasoning Tasks Arya S. Rao, Kaiz P. Esmail, Richard S. Lee, et al JAMA Netw Open 2026;9;(4):e264003. doi:10.1001/jamanetworkopen.2026.4003 Key Points Question  Can off-the-shelf large language models (LLMs) demonstrate reliable performance across the clinical workflow? Findings  In this cross-sectional study of 21 frontier LLMs tested on ...

ORIGINAL ARTICLE Cefazolin for Methicillin-Susceptible Staphylococcus aureus Bacteremia The Staphylococcus aureus Network Adaptive Platform (SNAP) Trial Group N Engl J Med 2026;394:2329-2339 DOI: 10.1056/NEJMoa2506905 Abstract BACKGROUND Staphylococcus aureus bacteremia is associated with high mortality. Whether cefazolin or an antistaphylococcal penicillin should be preferred for the treatment of methicillin-susceptible S. aureus&...

Original Investigation  An American College of Surgeons National Quality Improvement Collaborative to Enhance Lung Cancer Surgical Quality Kelley Chan, Eileen M. Reilly, Ryan C. Jacobs, et al JAMA Surg Published Online: April 15, 2026 doi: 10.1001/jamasurg.2026.0902 Key Points Question  Can a national quality improvement (QI) collaborative model increase compliance for a lung cancer operative standard? Findings  Among 354 accr...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS Understanding the Disease Cardiac output and determinantsBhattacharjee, S., Ferrer, R. & Hamzaoui, O. LATEST ARTICLES Editorial Defining ECMO complications: a step towards improving clinical outcomes?Brown, A., Barbaro, R. Update on long-term physical disability after critical illness: the burden of post-intensive care syndromeHermann, M., Karner, V. & Schaller, S.J. Immunosuppressiv...

Original Investigation  Intrawound Tobramycin Plus Vancomycin to Prevent Surgical Site Infection in Tibial Fractures: The TOBRA Randomized Clinical Trial Major Extremity Trauma Research Consortium (METRC) JAMA Published online: April 15, 2026 doi: 10.1001/jama.2026.4023 Key Points Question  Is the combination of intrawound tobramycin and vancomycin powder more effective than vancomycin powder alone to reduce deep surgical site infection in...