Original Investigation  April 16, 2025 Operative vs Nonoperative Treatment of Acute Cholecystitis in Older Adults With Multimorbidity Rachael C. Acker, Sara P. Ginzberg, James Sharpe, et al JAMA Surg. Published online April 16, 2025. doi:10.1001/jamasurg.2025.0729 Key Points Question  Is operative or nonoperative treatment better for treating acute cholecystitis in older adults with multimorbidi...

Research Letter  Gastroenterology and Hepatology May 21, 2025 Acute Kidney Injury and Hepatorenal Syndrome Among Hospitalized Patients With Chronic Liver Disease Robert J. Wong, Jeyasankar Balasubramanian, Mary Panaccio, et al JAMA Netw Open. 2025;8(5):e2511816. doi:10.1001/jamanetworkopen.2025.11816 Introduction The prevalence of chronic liver disease (CLD) is increasing,1,2 with alcohol-related ...

Update: Guidelines on Adult Critical Care Ultrasonography In ICU Tue, 4 Mar 2025 Critical care ultrasonography (CCUS) is a point-of-care tool used by clinicians to aid diagnosis, manage care, and guide procedures for critically ill patients. It has become widely adopted in critical care, but its impact on patient outcomes remains uncertain. This executive summary updates previous CCUS guidelines by comparing clinical outcomes with and without CCUS i...

Original Investigation  Less Is More April 10, 2025 Improving Empiric Antibiotic Selection for Patients Hospitalized With Skin and Soft Tissue Infection: The INSPIRE 3 Skin and Soft Tissue Randomized Clinical Trial Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Intern Med. Published online April 10, 2025. doi:10.1001/jamainternmed.2025.0887 Key Points Question  Can computerized pr...

Invited Commentary  Pediatrics April 11, 2025 Vasoactive Selection for Pediatric Septic Shock—Where to Begin? Scott L. Weiss JAMA Netw Open. 2025;8(4):e254726. doi:10.1001/jamanetworkopen.2025.4726 Vasoactive medications are commonly used to reverse cardiovascular dysfunction and optimize tissue perfusion in children with fluid-refractory or fluid-averse septic shock. The 2020 Surviving Sepsis Campaign International Guidelines for the Mana...

Variability in Interprofessional ICU Staffing In ICU Tue, 4 Mar 2025 ICU staffing varies widely due to factors like physician work-hour limitations, increased use of advanced practice providers (NPs and PAs), telemedicine, and shortages of healthcare workers, including nurses and ICU physicians. There is limited and low-quality data to guide staffing decisions, with most research focusing on individual roles rather than the interprofessional teams that...

Original Investigation  Pediatrics April 11, 2025 Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock Matthew A. Eisenberg, Nathan Georgette, Alexandra H. Baker, et al JAMA Netw Open. 2025;8(4):e254720. doi:10.1001/jamanetworkopen.2025.4720 Key Points Question  Is there an association between the first vasoactive agent administered and outcomes in children with se...

Research Letter  April 9, 2025 Concordance of 30-Day Mortality and In-Hospital Mortality or Hospice Discharge After Sepsis Hallie C. Prescott, Megan Heath, Namita Jayaprakash, et al JAMA. Published online April 9, 2025. doi:10.1001/jama.2025.2526 Sepsis contributes to 1.7 million adult hospitalizations and 350 000 deaths annually in the United States.1To encourage improvements in sepsis management and outcom...

Invited Commentary  Health Informatics April 7, 2025 Are All Cytokine Storms Born Equal? Andre C. Kalil, Anum Abbas, Sias J. Scherger JAMA Netw Open. 2025;8(4):e253466. doi:10.1001/jamanetworkopen.2025.3466 One of the most difficult medical challenges we have faced for decades is regarding the human host response to infectious and noninfectious insults. We are still lacking understanding on what constitutes adaptive and maladaptive host re...

Original Investigation  Health Informatics April 7, 2025 Cytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy James P. Long, Rishab Prakash, Paul Edelkamp Jr, et al JAMA Netw Open. 2025;8(4):e253455. doi:10.1001/jamanetworkopen.2025.3455 Key Points Question  How do clinical patterns and outcomes of cytokine storm (CS) vary among etiologies of cytokine releas...