Original Investigation  Public Health Computed Tomographic Screening Intervals for Patients at Moderate Risk of Lung Cancer Koen de Nijs, Harry J. de Koning, Pianpian Cao, et al JAMA Netw Open 2025;8;(7):e2523044. doi:10.1001/jamanetworkopen.2025.23044 Key Points Question  Can the benefits of lung cancer screening be preserved while reducing the burden by adapting the annual screening interval to age, sex...

Phosphate-Sparing Solution to Prevent Hypophosphataemia in Patients Undergoing CRRT In ICU Tue, 20 May 2025 ICU Management & Practice, Volume 25 - Issue 2, 2025 Phosphate-based solutions used during continuous renal replacement therapy (CRRT) significantly reduce the incidence of hypophosphataemia in critically ill patients. These solutions are safe, improve phosphate balance, and may shorten ICU stay and ventilation duration, though further multice...

Noninvasive Ventilation vs High-Flow Nasal Oxygen After Extubation In ICU Mon, 12 May 2025 In ICUs, extubation decisions are challenging, as 20-30% of patients experience post-extubation respiratory failure, with 10-15% requiring reintubation. Reintubation has high mortality rates and is a key patient outcome in the post-extubation period.  Noninvasive ventilation (NIV) and high-flow nasal oxygen (HFNO) therapies, when applied immediately after...

Original Investigation  Statistics and Research Methods Predictive Modeling of Heterogeneous Treatment Effects in RCTs: A Scoping Review Joe V. Selby, Carolien C. H. M. Maas, Bruce H. Fireman, et al JAMA Netw Open 2025;8;(7):e2522390. doi:10.1001/jamanetworkopen.2025.22390 Key Points Question  How often has the 2020 Predictive Approaches to Treatment Heterogeneity (PATH) Statement been cited in published ...

LATEST ISSUE IN MEMORIAM In Memoriam Rinaldo Bellomo: A RemembranceKellum J. A., Ostermann  M. & Ronco C. Rinaldo Bellomo: relentless architect of modern intensive careForni L. G., Hodgson C. & Prowle J. R. ICU TOOLBOX Editorial From bedside to data and back to bedside: why do we need better data to perform trauma phenotyping and improve trauma care?Gauss T., Bouzat P .& Josse J. The Doppler combined assessment of splanchnic perfusion a...

Original Investigation  Health Informatics Operationalization of Artificial Intelligence Applications in the Intensive Care Unit: A Systematic Review Willemijn E. M. Berkhout, Julia J. van Wijngaarden, Jessica D. Workum, et al JAMA Netw Open 2025;8;(7):e2522866. doi:10.1001/jamanetworkopen.2025.22866 Key Points Question  What is the current state of artificial intelligence (AI) use in intensive care units...

Pathophysiological Role and Management of Carbon Dioxide in Acute Brain Injury In ICU Mon, 12 May 2025 Maintaining proper cerebral oxygen delivery is crucial for preventing secondary ischaemic injury in patients with acute brain injuries (ABI). Arterial carbon dioxide tension (PaCO₂) significantly influences cerebral blood flow (CBF). When intracranial pressure (ICP) is not elevated, adjusting PaCO₂ to an optimal level can support sufficient cerebral o...

Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL) Mekontso Dessap, A., Ricard, JD., Contou, D. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08002-z Abstract Purpose To determine the dose of melatonin with an optimal pharmacokinetic profile and to test whether this dose reduces the prevalence of deliri...

Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial Voiriot, G., Argaud, L., Cohen, Y. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08014-9 Abstract Purpose Multiplex polymerase chain reaction (mPCR) testing has the potential to rapidly and accurately identify causative microorganisms in patients wi...

Mechanical Power in ARDS: Hand in Hand With Gattinoni ICU Management & Practice, Volume 25 - Issue 2, 2025 PRINT OPTIMISED SCREEN OPTIMISED High levels of mechanical power are associated with a higher incidence of lung damage and worse outcomes in patients with Acute Respiratory Distress Syndrome. This article explores the fundamentals of mechanical power, proper regulation of ventilatory support and the prevention of lung damage associated with mecha...