LATEST ISSUE IN MEMORIAM In Memoriam Rinaldo Bellomo: A RemembranceKellum J. A., Ostermann  M. & Ronco C. Rinaldo Bellomo: relentless architect of modern intensive careForni L. G., Hodgson C. & Prowle J. R. ICU TOOLBOX Editorial From bedside to data and back to bedside: why do we need better data to perform trauma phenotyping and improve trauma care?Gauss T., Bouzat P .& Josse J. The Doppler combined assessment of splanchnic perfusion a...

Original Investigation  Health Informatics Operationalization of Artificial Intelligence Applications in the Intensive Care Unit: A Systematic Review Willemijn E. M. Berkhout, Julia J. van Wijngaarden, Jessica D. Workum, et al JAMA Netw Open 2025;8;(7):e2522866. doi:10.1001/jamanetworkopen.2025.22866 Key Points Question  What is the current state of artificial intelligence (AI) use in intensive care units...

Pathophysiological Role and Management of Carbon Dioxide in Acute Brain Injury In ICU Mon, 12 May 2025 Maintaining proper cerebral oxygen delivery is crucial for preventing secondary ischaemic injury in patients with acute brain injuries (ABI). Arterial carbon dioxide tension (PaCO₂) significantly influences cerebral blood flow (CBF). When intracranial pressure (ICP) is not elevated, adjusting PaCO₂ to an optimal level can support sufficient cerebral o...

Melatonin for prevention of delirium in patients receiving mechanical ventilation in the intensive care unit: a multiarm multistage adaptive randomized controlled clinical trial (DEMEL) Mekontso Dessap, A., Ricard, JD., Contou, D. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08002-z Abstract Purpose To determine the dose of melatonin with an optimal pharmacokinetic profile and to test whether this dose reduces the prevalence of deliri...

Combined use of a multiplex PCR and serum procalcitonin to reduce antibiotic exposure in critically ill patients with community-acquired pneumonia: the MULTI-CAP randomized controlled trial Voiriot, G., Argaud, L., Cohen, Y. et al. Intensive Care Med(2025). https://doi.org/10.1007/s00134-025-08014-9 Abstract Purpose Multiplex polymerase chain reaction (mPCR) testing has the potential to rapidly and accurately identify causative microorganisms in patients wi...

Mechanical Power in ARDS: Hand in Hand With Gattinoni ICU Management & Practice, Volume 25 - Issue 2, 2025 PRINT OPTIMISED SCREEN OPTIMISED High levels of mechanical power are associated with a higher incidence of lung damage and worse outcomes in patients with Acute Respiratory Distress Syndrome. This article explores the fundamentals of mechanical power, proper regulation of ventilatory support and the prevention of lung damage associated with mecha...

Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial Ke, L., Li, G., Mao, W. et al. Intensive Care Med (2025). https://doi.org/10.1007/s00134-025-08020-x Abstract Purpose Acute necrotic collection (ANC) is an early, local complication of necrotizing pancreatitis, and guidelines recommend a deliberate delay in treating ANC. In patients with ear...

Predicting Septic Shock Mortality in ICUs with AI  In Sepsis Sun, 4 May 2025 Septic shock, a severe manifestation of sepsis, poses a persistent threat to patients in intensive care units (ICUs), with its complex pathophysiology and high mortality rates making early intervention difficult. Previous machine learning models have attempted to predict sepsis outcomes but were limited by narrow patient scopes, insufficient validation, or low generalisab...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT OPEN ACCESS ~ What's New in Intensive Care Renal replacement therapyGaudry S., Srisawat N. & Joannidis M. LATEST ARTICLES Original Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohortMonet C., Bouziane J., Pensier J., et al. Altered lower brainstem neurophysiological response is asso...

Original Investigation  Health Informatics Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions: A Systematic Review and Meta-Analysis Badal S. B. Pattar, Abigail Ackroyd, Emir Sevinc, et al JAMA Netw Open 2025;8;(7):e2521785. doi:10.1001/jamanetworkopen.2025.21785 Key Points Question  Are electronic health record (EHR)–based interventions associated with reduced risk of hospital...