Original Research Quality of Human Expert versus Large Language Model Generated Multiple Choice Questions in the Field of Mechanical Ventilation Sami Safadi, Roxana Amirahmadi, Abdulhakim Tlimat, et al Chest Available online 18 July 2025 https://doi.org/10.1016/j.chest.2025.07.005 Abstract Background Mechanical ventilation (MV) is a critical competency in critical care training, yet standardized methods for assessing MV-related knowledge are lacking. ...

Intravenous Tenecteplase Before Endovascular Thrombectomy In ICU Tue, 3 Jun 2025 Intravenous thrombolysis before endovascular thrombectomy (EVT) in stroke patients has potential benefits for improving reperfusion but also carries a risk of increased intracranial haemorrhage. Since 2018, six randomised trials have found no significant difference in outcomes between combining thrombolysis (mainly with alteplase) and EVT versus EVT alone. Tenecteplase, a ...

Critical Care: Original Research Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Kevin P. Seitz, Bradley D. Lloyd, Li Wang, et al Chest Available online 4 April 2025 https://doi.org/10.1016/j.chest.2025.03.024 Background Whether the choice of ventilator mode affects outcomes for critically ill patients is unknown. Research Question What are the effects of 3 common ventilator modes (volume cont...

CRITICAL CARE: ORIGINAL RESEARCH Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial Edward T. Qian, Ryan M. Brown, Karen E. Jackson, et al Chest 2025; 168: 336-345 Abstract Background Balanced crystalloid solutions may improve clinical outcomes compared with saline for some critically ill adults, but it is unclear whether differences in composition between balanced crystalloid solutions affect outcomes. Research Question Does ...

OPTPRESS: Targeting High Mean Arterial Pressure for Patients With Septic Shock  In Sepsis Tue, 3 Jun 2025 Sepsis is a serious global health issue, with septic shock carrying a high mortality rate (~38.5%). The optimal blood pressure target for managing septic shock remains unclear. Recent trials show that maintaining a mean arterial pressure (MAP) above 65 mmHg isn’t always beneficial, but higher targets (80–85 mmHg) may help patients with chronic...

Original Investigation  Occupational Health Smartwatch Use and Physician Well-Being: A Randomized Clinical Trial Liselotte N. Dyrbye, Colin P. West, Angelina R. Wilton, et al JAMA Netw Open Published Online: August 18, 2025 2025;8;(8):e2527275. doi:10.1001/jamanetworkopen.2025.27275 Key Points Question  Does wearing a smartwatch and having access to its physiological data (eg, sleep, ste...

Original Investigation  Health Policy Variation, Overlap, and Stability in Defining Safety Net Hospitals Paula Chatterjee, Joshua M. Liao, Kano Amagai, et al JAMA Netw Open 2025;8;(7):e2523923. doi:10.1001/jamanetworkopen.2025.23923 Key Points Question  To what extent do different definitions for safety net hospitals overlap, change over time, and represent similar types of facilities? Findings &n...

Editor's Note  What if Readmission Prevents Death?—The Challenge of Composite Outcomes Deborah Grady, Raegan W. Durant, Timothy S. Anderson JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3709 Composite outcomes, which combine several different events into a single outcome, are frequently used in clinical trials. Clinical trials testing transition of care interventions often measure distinct outcomes such as readmissio...

Original Investigation  Proactive Telehealth-Based Sepsis Transition and Recovery Support, Hospital Readmission, and Mortality: A Randomized Clinical Trial Stephanie Parks Taylor, Tara Eaton, Aleta Rios, et al JAMA Intern Med Published Online: August 11, 2025 doi: 10.1001/jamainternmed.2025.3699 Key Points Question  Does a multicomponent, navigator-led sepsis transition and recovery (STAR) progr...

#EA25: Managing the Bloody AirwayIn ICUMon, 26 May 2025 Difficult airway management is a core competency for any anaesthesiologist and can often mean the difference between life and death. Among the most complex and high-risk scenarios is the bloody airway, where active bleeding significantly impairs visibility and complicates even standard difficult airway techniques. Failure to control bleeding in the airway is a major contributor to airway-related mortality. ...