Research Effectiveness of mRNA-1273 against delta, mu, and other emerging variants of SARS-CoV-2: test negative case-control study Katia J Bruxvoort, Lina S Sy, Lei Qian, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068848 (Published 15 December 2021)Cite this as: BMJ 2021;375:e068848 Abstract Objectives To evaluate the effectiveness of the mRNA-1273 vaccine against SARS-CoV-2 variants and assess its effectiveness against the delta variant...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES Originals Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort studyAngriman F. et al. OPEN ACCESS ~ Veno-venous extracorporeal membrane oxygenation (vv-ECMO) for severe respiratory failure in adult cancer patients: a retrospective multicenter analysisKochanek M. et al. Factors associated with acute mesenteric ischemia among critically ill ventilated patie...

ORIGINAL ARTICLE Population Immunity and Covid-19 Severity with Omicron Variant in South Africa Shabir A. Madhi, Gaurav Kwatra, Jonathan E. Myers, et al N Engl J Med February 23, 2022DOI: 10.1056/NEJMoa2119658 Abstract BACKGROUND The B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified on November 25, 2021, in Gauteng province, South Africa. Data regarding the seroprevalence of SARS-CoV-2 IgG in...

ICU Management & Practice, Volume 21 - Issue 6, 2021 Emergencies in Malignant Haematology for the Intensivist An overview of emergencies that are commonly seen in malignant haematology, side effects of novel therapies, and complications of allogeneic haematologic stem cell transplant. Introduction Critical illness is common in patients with haematologic malignancies. Recent data demonstrate that 14% of patients will require ICU admission within one ye...

Research Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial BMJ 2022; 376 doi: https://doi.org/10.1136/bmj-2021-068407 (Published 07 January 2022)Cite this as: BMJ 2022;376:e06840 Abstract Objective To assess the effect of statin treatment versus placebo on clinical outcomes in patients with covid-19 admitted to the intensive care unit (ICU). Design INSPIRATION/IN...

COMMENT| VOLUME 10, ISSUE 3, P223-224, MARCH 01, 2022 Stimulating severe COVID-19: the potential role of GM-CSF antagonism Helen L Leavis, Frank L van de Veerdonk, Srinivas Murthy Lancet Respir Med 2022; 10: 223-224 Over the past 20 months of the COVID-19 pandemic, a great deal has been crystallised about the ideal therapeutic targets for infected patients. For very sick patients who require hospitalisation, we now know that targeting the dysreg...

ICU Management & Practice, Volume 21 - Issue 6, 2021 Indirect Calorimetry in Mechanically Ventilated Patients to Assess Nutritional Targets An overview of the physiological aspects of indirect calorimetry, its limitations in use, the available literature and future prospects for tailored nutrition. Introduction Medical nutrition therapy (MNT) is an essential part of patient care in the intensive care unit (ICU) setting. Similar to mechanical ventilati...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES ICM Rapid Practice GuidelinesERC-ESICM guidelines on temperature control after cardiac arrest in adultsSandroni C. et al. OriginalsMental health symptoms in family members of COVID-19 ICU survivors 3 and 12 months after ICU admission: a multicentre prospective cohort studyHeesakkers H. et al.Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in...

ORIGINAL ARTICLEFREE PREVIEW 24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk Yuan Ma, Feng J. He, Qi Sun, et al N Engl J Med 2022; 386:252-263DOI: 10.1056/NEJMoa2109794 Abstract BACKGROUND The relation between sodium intake and cardiovascular disease remains controversial, owing in part to inaccurate assessment of sodium intake. Assessing 24-hour urinary excretion over a period of multiple days is considered to be an accurate metho...

ONLINE FIRST (FREE ACCESS) LATEST ARTICLES OriginalUndocumented migrants in French intensive care units in 2011–2018: retrospective nationwide studyHraiech S. et al. Systematic Review Effect of prone positioning on survival in adult patients receiving venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysisPapazian L. et al. EditorialTowards evidence-based staffing: the promise a...