Reducing Hospitalisations Through Risk Prediction  In ICU Mon, 7 Jul 2025 Preventing unplanned hospital admissions among older adults is an ongoing challenge for hospitals seeking to maintain patient safety while optimising resource use. Emergency admissions are associated with adverse outcomes, including cognitive decline, hospital-acquired infections and repeat admissions. Understanding the factors that contribute to such admissions is critical ...

Original Investigation  Proactive vs Reactive Treatment of Hypotension During Surgery: The PRETREAT Randomized Clinical Trial Matthijs Kant, Wilton A. van Klei, Markus W. Hollmann, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.18007 Key Points Question  Does intraoperative blood pressure management with a mean arterial pressure goal stratified by preoperatively determined ...

Original Investigation  Individualized Perioperative Blood Pressure Management in Patients Undergoing Major Abdominal Surgery: The IMPROVE-multi Randomized Clinical Trial Bernd Saugel, Agnes S. Meidert, Frank M. Brunkhorst, et al JAMA Published Online: October 12, 2025 doi: 10.1001/jama.2025.17235 Key Points Question  Does individualized perioperative blood pressure management based on preoperative n...

Mortality and Antibiotic Timing in Deep Learning-Derived Sepsis Risk Groups In Sepsis Tue, 15 Jul 2025 Sepsis affects over 1.7 million people annually in the U.S., causing more than 350,000 deaths and over $62 billion in healthcare costs. The 2021 Surviving Sepsis Campaign (SSC) guidelines recommend antibiotic timing based on illness severity and sepsis probability, creating four risk categories, but this classification is subjective and ofte...

Original Investigation  Pacific Coast Surgical Association Dexmedetomidine for Analgesia in Nonintubated Patients With Traumatic Rib Fractures: A Randomized Clinical Trial Jeffry Nahmias, Stephen Stopenski, Mallory Jebbia, et al JAMA Surg 2025;160;(10):1047-1056. doi:10.1001/jamasurg.2025.3221 Key Points Question  Does the addition of dexmedetomidine to standard multimodal analgesia reduce opioid consumpt...

Comment Reducing just-in-case primary care antibiotic prescribing in children Alastair D Hay, Emily Brown Lancet 2025; 406: 1538-1540 As health-care workers around the world will attest, infections are extremely common in children in primary care and community settings.1, 2 In The Lancet, Jan Yvan Verbakel and colleagues' pragmatic, cluster-randomised, controlled trial (ARON),3 set in a high-income primary care system, reports the culminati...

Articles The global, regional, and national burden of cancer, 1990–2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Cancer Collaborators Lancet 2025; 406: 1565-1586 Summary Background Cancer is a leading cause of death globally. Accurate cancer burden information is crucial for policy planning, but many countries do not have up-to-date cancer surveillance data. To inform global cancer-control effort...

Invited Commentary  Reducing Missed Doses of VTE Prophylaxis John T. Simpson, Krista L. Haines, Suresh Agarwal JAMA Surg Published Online: October 8, 2025 doi: 10.1001/jamasurg.2025.4142 In their prospective cohort study, Haut et al1 apply a quality improvement intervention to reduce missed venous thromboembolism (VTE) chemoprophylaxis among patients hospitalized in a community hospital. Through nursing education, real-time missed dose alerts, and a pa...

Original Investigation  Implementing a Patient-Centered Education Bundle to Improve Venous Thromboembolism Prevention Elliott R. Haut, Oluwafemi P. Owodunni, Dauryne L. Shaffer, et al JAMA Surg Published Online: October 8, 2025 doi: 10.1001/jamasurg.2025.4136 Key Points Question  Does a comprehensive intervention to address missed doses of venous thromboembolism (VTE) prophylaxis reduce missed d...

Research Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial  Perry Wilson, Melissa Martin, Yu Yamamoto, et al BMJ 2021; 372 doi: https://doi.org/10.1136/bmj.m4786 (Published 18 January 2021)Cite this as: BMJ 2021;372:m4786 Abstract Objective To determine whether electronic health record alerts for acute kidney injury would improve patient outcomes of mortality, dialysis, and progression of acute kidney injur...