Research Letter  Oncology “Me-Too” Drugs Compared With Original Drugs in Randomized Clinical Trials Timothée Olivier, Calvin Smith, Vinay Prasad, et al JAMA Intern Med Published Online: July 14, 2025 doi: 10.1001/jamainternmed.2025.2892 The development of “me-too” or “next-in-class” drugs in oncology may offer benefits including improved efficacy, better safety profiles, or economic competition.1,2 Addi...

Enteral Nutrition in Critically Ill Patients  In ICU Tue, 6 May 2025 Enteral nutrition delivers essential nutrients to treat or prevent disease-related malnutrition in critically ill patients. This malnutrition, influenced by poor intake and inflammation, can impact the effectiveness of nutrition therapy. Evidence from recent randomised trials in both critically ill and non-critically ill patients has shaped current practices.  A recent re...

Editorials Addressing the indirect health burden of covid-19 Zhihao Lei BMJ 2025; 390 doi: https://doi.org/10.1136/bmj.r1268 (Published 02 July 2025)Cite this as: BMJ 2025;390:r1268 Consider collateral impacts when planning for future crises The covid-19 pandemic’s impact extends far beyond the direct effects of infection and death, resulting in sharp increases in other causes of illness and death that demand attention. A new time-series analysis of the Glo...

Original Investigation  Public Health Body Mass Index in Children Before, During, and After the COVID-19 Pandemic Frederik Kirkemann Jensen, Sigrid Bjerge Gribsholt, Sara Schwartz, et al JAMA Netw Open 2025;8;(7):e2519528. doi:10.1001/jamanetworkopen.2025.19528 Key Points Question  Did prevalence of underweight, overweight, and obesity in schoolchildren change during and after the COVID-19 pandemic compared wi...

In-Hospital Mortality Using Admission CT Perfusion in Severe TBI  In ICU Tue, 6 May 2025 Traumatic brain injury (TBI) is classified into mild, moderate, and severe categories, with severe TBI (defined by a Glasgow Coma Scale ≤8) being the leading cause of hospitalisation, disability, and mortality worldwide. Globally, over 50 million people suffer from TBI annually, costing around $400 billion each year. Severe TBI is a clinical emergency that ...

Research Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic: time-series modelling analysis of global burden of disease study 2021 Can Chen, Wenkai Zhou, Yifan Cui, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2024-083868 (Published 02 July 2025)Cite this as: BMJ 2025;390:e083868 Abstract Objective To quantify and identify the main caus...

CRITICAL CARE: ORIGINAL RESEARCHVolume 168, Issue 1P119-130July 2025 Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial Xiao Tang, Yan-Mei Gu, Yuan Shi, et al Chest 2025; 168: 119-130 Abstract Background The cuff leak test (CLT) is an important tool to assess the risk of upper airway obstruction after extubation. Research Questi...

CRITICAL CARE: ORIGINAL RESEARCHVolume 168, Issue 1P106-118July 2025Open AccessDownload Full Issue Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life Nicolas Paul, Elena Ribet Buse, Julius J. Grunow, et al Chest 2025; 168: 106-118 Abstract Background There is limited knowledge about long-term mortality, care pathways, and health-related quality of life (HrQoL) among patients in the IC...

Invited Commentary  Surgery Variability in Delirium After Noncardiac Surgery—Nature vs Nurture Jessica D. Spence, Emilie Belley-Côté JAMA Netw Open 2025;8;(7):e2519476. doi:10.1001/jamanetworkopen.2025.19476 In adults older than 60 years, surgery is a well-known precipitant of delirium, an acute neuropsychiatric condition characterized by an altered consciousness and fluctuating episodes of confusion and inattention.1 A recent systematic review2&n...

RECUVAP: Consensual Definition of VAP Recurrences and Various Types  In ICU Tue, 6 May 2025 Ventilator-associated pneumonia (VAP) is a common healthcare-associated infection in ICUs, linked to increased mortality, longer mechanical ventilation, and extended ICU stays. Diagnostic criteria for the first episode of VAP include clinical suspicion, chest x-ray infiltrates, and positive microbiological cultures from lower respiratory tract specimens. Ho...