Articles Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis Ioannis Gallos, Caitlin R Williams, Malcolm J Price, et al Lancet 2025; 406: 1969-1982 https://doi.org/10.1016/S0140-6736(25)01639-3 Summary Background Postpartum haemorrhage (excessive bleeding after birth) is a leading cause of maternal mortality and morbidity worldwide. However...

Comment Treatment of MSSA bacteraemia: a call for a personalised approach Carol M Kao, Stephanie A Fritz Lancet Available online 17 October 2025 https://doi.org/10.1016/S0140-6736(25)01844-6 Staphylococcus aureus infections remain a formidable health threat, responsible for the most infection-related deaths worldwide and a mortality rate of up to 30%, despite contemporary infection prevention practices, antimicrobial stewardship, and nov...

Original Investigation  Eltrombopag for Newly Diagnosed Pediatric Immune Thrombocytopenia Requiring Treatment: The PINES Randomized Clinical Trial Kristin A. Shimano, Amanda B. Grimes, Shipra Kaicker, et al JAMA Published Online: October 22, 2025 doi: 10.1001/jama.2025.18168 Key Points Question  What is the efficacy of eltrombopag compared with standard therapy in children with newly diagnosed i...

Patient-Important Upper Gastrointestinal Bleeding In ICU Fri, 26 Sep 2025 Critically ill patients are prone to stress-related erosions that can lead to upper gastrointestinal (GI) bleeding. While previous studies defined clinically important bleeding by investigator criteria, a new outcome measure, patient-important upper GI bleeding, was developed with input from ICU survivors and families. This definition excludes haemodynamic or lab thresholds and i...

Articles Cloxacillin versus cefazolin for meticillin-susceptible Staphylococcus aureus bacteraemia (CloCeBa): a prospective, open-label, multicentre, non-inferiority, randomised clinical trial Charles Burdet, Nadia Saïdani, Céline Dupieux, et al Lancet Available online 17 October 2025 https://doi.org/10.1016/S0140-6736(25)01624-1 Summary Background Although widely used, cefazolin efficacy for the treatment of meticillin-susceptible Staphylococcus...

Research Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial Parco M Siu, Danny J Yu, Angus P Yu, et al BMJ 2025; 391 doi: https://doi.org/10.1136/bmj-2025-084320 (Published 26 November 2025)Cite this as: BMJ 2025;391:e084320 Abstract Objective To assess whether tai chi is non-inferior to cognitive behavioural therapy for insomnia (CBT-I), the first line treatment, for managin...

Original Investigation  Hematology Cost-Effectiveness of Cryopreserved vs Liquid-Stored Platelets for Managing Surgical Bleeding Zhomart Orman, Michael C. Reade, Denese C. Marks, et al JAMA Netw Open 2025;8;(12):e2554363. doi:10.1001/jamanetworkopen.2025.54363 Key Points Question  Are cryopreserved platelets cost-effective compared with liquid-stored platelets for managing active bleeding in patients unde...

Original Investigation  Rituximab for Relapsing Nephrotic Syndrome in Adults: A Randomized Clinical Trial Yoshitaka Isaka, Yusuke Sakaguchi, Maki Shinzawa, et al JAMA 2025;334;(22):2011-2019. doi:10.1001/jama.2025.19316 Key Points Question  Does rituximab, compared with placebo, prevent relapse in adult patients with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome? Findings&n...

Ventilatory Management of the Surgical Critically Ill Patient In ICU Fri, 26 Sep 2025 Postoperative management of critically ill surgical patients requires tailored approaches for each type of surgery, but core principles, especially optimising mechanical ventilation, remain consistent.  A recent article outlines essential strategies and recent advances in best practices for respiratory support in ICU postoperative care. The IMPROVE trial de...

Original Investigation  Gastroenterology and Hepatology Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis: A Randomized Clinical Trial Wenhua He, Ling Ding, Zhijun Liu, et al JAMA Netw Open 2025;8;(11):e2542124. doi:10.1001/jamanetworkopen.2025.42124 Key Points Question  Is low-molecular-weight heparin combined with insulin superior to insulin alone in improving clinical...