ARTICLES|ONLINE FIRST Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial Matthew F Mart, Leanne M Boehm, Amy L Kiehl, et al Lancet Respire Med Published:April 30, 2024 DOI:https://doi.org/10.1016/S2213-2600(24)00077-8 Summary Background Delirium is common during critical illness and is associated with long-term cognitive impairment and disability. Antip...

Original Investigation  Pediatrics June 5, 2024 Delays to Antibiotics in the Emergency Department and Risk of Mortality in Children With Sepsis Roni D. Lane, Troy Richardson, Halden F. Scott, et al JAMA Netw Open. 2024;7(6):e2413955. doi:10.1001/jamanetworkopen.2024.13955 Key Points Question  Is the timing of antibiotic administration associated with sepsis-attributable mortality in pediatric...

Decision-Making in the PICU: Ethical Aspects in Paediatric Critical Patients In ICU Fri, 19 Apr 2024 This article highlights some particularities to be considered when making decisions in paediatric ICUs and the role of parents (or legal guardians) and the physician in the dilemma involved in paediatric decision-making.   In these times, an ill individual is believed to be an autonomous moral agent to make decisions regarding their health. Decis...

Invited Commentary  Critical Care Medicine May 31, 2024 Sepsis Quality Measurement and the Fraying of the Safety Net Jeremy M. Kahn JAMA Netw Open. 2024;7(5):e2412781. doi:10.1001/jamanetworkopen.2024.12781 Hospitals in the US are increasingly subject to government regulations intended to improve the quality of care for patients with sepsis. Examples include the Centers for Medicare and Medicaid Services sepsis management bundle program (S...

Original Investigation  Emergency Medicine May 7, 2024 Use of a Large Language Model to Assess Clinical Acuity of Adults in the Emergency Department Christopher Y. K. Williams, Travis Zack, Brenda Y. Miao, et al JAMA Netw Open. 2024;7(5):e248895. doi:10.1001/jamanetworkopen.2024.8895 editorial comment icon  Editorial  Comment Key Points Question  Can a large language ...

Original Investigation  Geriatrics May 31, 2024 Geriatric End-of-Life Screening Tool Prediction of 6-Month Mortality in Older Patients Adrian D. Haimovich, Ryan C. Burke, Larry A. Nathanson, et al JAMA Netw Open. 2024;7(5):e2414213. doi:10.1001/jamanetworkopen.2024.14213 Key Points Question  Can the Geriatric End-of-Life Screening Tool (GEST) accurately identify older adults in the emergency ...

Transforming Research to Improve Therapies for Trauma In ICU Tue, 30 Apr 2024 The impact of trauma on global health is significant, resulting in millions of deaths and disabilities annually, with a particularly high toll on young people. However, the elderly are also increasingly affected. Variances in trauma-related death patterns worldwide are influenced by factors such as prompt treatment availability and the prevalence...

Original Investigation  Geriatrics May 31, 2024 Corticosteroid Injections and Risk of Fracture Terin T. Sytsma, Shannon Thomas; Karen M. Fischer, et al JAMA Netw Open. 2024;7(5):e2414316. doi:10.1001/jamanetworkopen.2024.14316 Key Points Question  Are high numbers of corticosteroid injections (CSIs) associated with subsequent fractures? Findings  In this cohort study of 7197 pati...

ONLINE FIRST (FREE ACCESS) ESICM GUIDELINES GuidelinesEuropean Society of Intensive Care Medicine clinical practice guideline on fluid therapy in adult critically ill patients. Part 1: the choice of resuscitation fluidsArabi Y. M. et al TOPICAL COLLECTION "ICU TOOLBOX" EditorialEmpirical antimicrobials in the intensive care unitDe Bus L., Arvaniti K. and Sjövall F.Using echocardiography to predict fluid-responsiveness and manage the need for fluidsVi...

Original Investigation  Hematology May 31, 2024 Optimal Oral Iron Therapy for Iron Deficiency Anemia Among US Veterans Nilang Patel, Scott G. Silvey, Pradeep Arora, et al JAMA Netw Open. 2024;7(5):e2414305. doi:10.1001/jamanetworkopen.2024.14305 Key Points Question  What is the preferred oral iron supplementation strategy in patients with iron deficiency anemia (IDA)? Findings  I...