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THE BRAIN IN THE LINE OF FIRE

Editorial

Neurotoxicity of sedative drugs: a matter of concern in adults?
Landoni G., Kotani Y. & Lomivorotov V.

Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidney
van Regenmortel N., van der Jagt M.

Transfusion targets after acute brain injury: the view of the trialists
Taccone, F. S., English, S. W. & Turgeon, A. F. 

OPEN ACCESS ~ What's New in Intensive Care

Delirium versus encephalopathy: a call for precise terminology
Kotfis, K., Kress, J.P. & Slooter, A.J.C.

STANDARD OF CARE IN THE INTENSIVE CARE UNIT

Editorial

Key principles and recent developments for ventilatory management of the surgical critically ill patient
De Jong, A., Jaber, S. & Schaefer, M.

What's New in Intensive Care

Why interventions to prevent acute kidney injury are needed now and why preventing long-term outcomes will only come later
Kellum, J.A., Zarbock, A.

LATEST ARTICLES

Conference Reports and Expert Panel

European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3—fluid removal at de-escalation phase
Ostermann, M., Alshamsi, F., Artigas Raventos, A. et al., on behalf of the European Society of Intensive Care Medicine

British societies guideline on the management of emergencies in patients on extracorporeal membrane oxygenation
Akhtar, W., Brain, N., Hernandez Caballero, C. et al.

Original

Heterogeneity in the response to a high vs low mean arterial pressure target in patients with septic shock a post hoc analysis of a randomized controlled trial

Pirracchio, R., Fong, N. & Legrand, M.

Temporal stability of phenotypes of acute respiratory distress syndrome: clinical implications for early corticosteroid therapy and mortality

Pensier, J., Fosset, M., Paschold, BS. et al.

Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial

Futier, E., De Jong, A., Cirenei, C. et al.

OPEN ACCESS ~ Original

A reappraisal of association between ventilator-associated events and mortality among critically ill patients using marginal structural model: multicenter observational study

Nakahashi, S., Suzuki, K., Nakashima, T. et al.

Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study

Schellongowski, P., Darmon, M., Eller, P. et al.

Monocyte HLA-DR expression in septic shock patients: insights from a 20-year real-world cohort of 1023 cases

Monneret, G., Lafon, T., Gossez, M. et al.

Effects of The Caregiver Pathway intervention on symptoms of post-intensive care syndrome among family caregivers to critically ill patients: long-term results from a randomized controlled trial
Watland, S., Solberg Nes, L., Ekeberg, Ø. et al.

Determinants of ICU memories and the impact on the development and trajectory of post-traumatic stress symptoms: a multicenter longitudinal cohort study
Kooken, R.W.J., Tilburgs, B., Slooter, A.J.C. et al.

Understanding the Disease

Head up, face down—a practical framework for proning brain-injured patients with ARDS
Wahlster, S., Town, J.A. & Robba, C.

Narrative Review

Antibiotic therapy for severe bacterial infections
Timsit, JF., Ling, L., de Montmollin, E. et al.

OPEN ACCESS ~ Narrative Review
Echocardiography guided management of atrial fibrillation
Balik, M., Vignon, P., Chew, M.S. et al. 

Systematic review

Ethical tensions and professional attitudes toward circulatory death organ donation in the ICU: a systematic review
Grossi, A.A., Baiardo Redaelli, M., Procaccio, F. et al.

Melatonin and delirium in the intensive care units: a systematic review and meta-analysis of randomized controlled trials
Lakbar, I., Poole, D., Delamarre, L. et al.

Editorial

Re-evaluating the impact of ventilator-associated events on mortality in critically ill patients: insights from advanced causal modelling
Iba, T., Ferrer, R. & Klompas, M.

From acute to chronic: the long-term consequences of AKI in South and Southeast Asia
Selby, N. M. & Bobot, M.

What's New in Intensive Care

Post-intensive care syndrome is a potential consequence of critical care: can intensivists afford to look away?
Rousseau, AF., Fraipont, V., Preiser, JC.

Lactate dynamics as a marker of perfusion: physiological interpretation and pitfalls
Levy, B., Hernandez, G. & Taccone, F.

OPEN ACCESS ~ What's New in Intensive Care
Exploring the dark side of the moon: diagnostic errors in critically ill patients
Valentin, A., Flaatten, H. & Dünser, M.W.

Understanding the Disease

Ten tips on non-therapeutic hypothermia
Nielsen, N. D., Spadoni, T., Leone, M. 

Imaging in Intensive Care Medicine

Nonketotic hyperglycemic hemichorea
Chen, JQ., Fan, WN.

Urinary tract fungus balls in an immunocompromised patient with persistent candida albicans fungemia
Hérault A., Vangheluwe L., Alexandre K. et al.

Scientific Letter

Sustainable development and intensive care medicine: high time for implementing education tools!
Guihenneuc, J., Ayraud-Thevenot, S., Lecronier, M. et al.