Original Investigation 

Pediatrics

Antenatal Corticosteroids and Infectious Diseases Throughout Childhood

Fabienne Decrue, Emily M. Frier, Chun Lin, et al

JAMA Netw Open 2025;8;(10):e2536809. doi:10.1001/jamanetworkopen.2025.36809

Key Points

Question  Is maternal antenatal corticosteroid treatment associated with increased susceptibility for respiratory and nonrespiratory infections in offspring from childhood to adulthood?

Findings  In this cohort study of 1 548 538 mother-child pairs, exposure to antenatal corticosteroid treatment was significantly associated with an increased risk of respiratory and nonrespiratory infections in preterm and full-term children through age 21 years.

Meaning  These findings might help inform discussion around the benefits and long-term risks of maternal antenatal corticosteroid treatment.

Abstract

Importance  International guidelines recommend the use of antenatal corticosteroids (ACS) in pregnancies at risk of imminent preterm birth before 34 weeks’ gestation. However, whether ACS leads to long-term risk of infection from childhood to adulthood is unknown.

Objective  To determine whether preterm (<37 weeks’ gestation) and full-term (37-41 weeks’ gestation) children exposed to ACS are more susceptible to respiratory and nonrespiratory infections compared with ACS-unexposed children throughout childhood and adolescence.

Design, Setting, and Participants  This population-based cohort study used data from the multicenter Consortium for the Study of Pregnancy Treatments (Co-OPT) study, including data from nationwide registries for mothers and their children in Finland and Scotland. Singleton children born from 1997 to 2018 and 2006 to 2018 in Scotland and Finland, respectively, were followed up until 2018, death, or first infection. Data were analyzed between June 2022 and October 2023.

Exposures  Maternal ACS treatment.

Main Outcomes and Measures  Primary and secondary outcomes were the first diagnosis of respiratory or nonrespiratory infection after birth-related hospital discharge. Outcomes were stratified by gestational age at birth.

Results  Among 1 548 538 included mother-child pairs (mean [SD] maternal age, 29.4 [5.7] years; mean [SD] gestational age at birth, 39.2 [1.7] weeks; 759 082 [49.0%] female neonates), 49 263 children (3.2%) were ACS-exposed, of whom 34 806 (70.7%) were preterm and 14 457 (29.3%) were full term at birth. ACS-exposed children had more respiratory and nonrespiratory infections than nonexposed children (incidence rate, 65.2 vs 39.8 and 30.0 vs 17.9 per 1000 person-years, respectively). Compared with nonexposed children, higher risks for respiratory and nonrespiratory infections were found among ACS-exposed children born at 34 weeks 0 days to 36 weeks 6 days’ gestation (adjusted hazard ratios [HRs], 1.10 [95% CI, 1.06-1.14] and 1.19 [95% CI, 1.15-1.24]), 37 0/7 to 38 6/7 weeks’ gestation (adjusted HRs, 1.27 [95% CI, 1.21-1.32] and 1.17 [95% CI, 1.11-1.23]), and 39 weeks 0 days to 41 weeks 6 days’ gestation (adjusted HRs, 1.23 [95% CI, 1.16-1.30] and 1.31 [95% CI, 1.22-1.40]). However, ACS-exposed children born at 28 weeks 0 days to 31 weeks 6 days’ gestation and 32 weeks 0 days to 33 weeks 6 days’ gestation showed no association between ACS exposure and respiratory and nonrespiratory infections.

Conclusion and Relevance  In this cohort study, exposure to ACS was associated with increased risks of infections in full-term children until age 21 years. In preterm children born before 34 weeks’ gestation, no association between ACS and infections was found. To minimize the adverse effects of ACS treatment, more stringent criteria for ACS administration and better prediction tools for preterm birth are required.