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ARTICLES|ONLINE FIRST Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial JoAnn Lindenfeld, Michael R Zile, Akshay S Desai, et al Lancet Published:August 27, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01754-2 Summary Background Previous studies have suggested that haemodynamic-guided management using an implantable pulmonary artery pressure monitor reduces heart failure hospitalisations in patients with moderatel...
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ORIGINAL ARTICLE Early Convalescent Plasma for High-Risk Outpatients with Covid-19 Frederick K. Korley, Valerie Durkalski-Mauldin, Sharon D. Yeatts, et al N Engl J Med August 18, 2021DOI: 10.1056/NEJMoa2103784 Abstract BACKGROUND Early administration of convalescent plasma obtained from blood donors who have recovered from coronavirus disease 2019 (Covid-19) may prevent disease progression in acutely ill, high-risk patients with Covid-19. METHODS I...
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ICU Management & Practice, Volume 20 - Issue 3, 2020 Infographic Problems associated with ageing, complications of critical illness in the elderly patient, and an overview of the gaps in the treatment of critically ill older adults.
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Research Letter August 13, 2021 Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection Zion Congrave-Wilson, Yesun Lee, Jaycee Jumarang, et al JAMA. Published online August 13, 2021. doi:10.1001/jama.2021.13967 While real-time reverse transcriptase–polymerase chain reaction (RT-PCR) on nasopharyngeal swabs is the current standard for SARS-CoV-2 detection, saliva is an attractive alternative...
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ARTICLES|ONLINE FIRST Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial PRISM trial group Lancet Respir Med Published:June 18, 2021 DOI: https://doi.org/10.1016/S2213-2600(21)00089- Summary Background Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuou...
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ARTICLES| VOLUME 9, ISSUE 8, P863-872, AUGUST 01, 2021 Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial Axel Bauer, Michael Schreinlechner, Nikolay Sappler, et al Lancet Respir Med 2021; 9: 863-872 DOI:https://doi.org/10.1016/S2213-2600(21)00214-9 Summary Background SARS-CoV-2 entry in human cells depends on angiotens...
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ORIGINAL ARTICLE Abelacimab for Prevention of Venous Thromboembolism Peter Verhamme, B. Alexander Yi, Annelise Segers, et al N Engl J Med 2021; 385:609-617DOI: 10.1056/NEJMoa2105872 Abstract BACKGROUND The role of factor XI in the pathogenesis of postoperative venous thromboembolism is uncertain. Abelacimab is a monoclonal antibody that binds to factor XI and locks it in the zymogen (inactive precursor) conformation. METHODS In this open-label, par...
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CORRESPONDENCE Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients Victoria G. Hall, Victor H. Ferreira, Terrance Ku, et al N Engl J Med August 11, 2021DOI: 10.1056/NEJMc2111462 TO THE EDITOR: In organ-transplant recipients, the standard two-dose vaccination strategy for coronavirus disease 2019 (Covid-19) has suboptimal immunogenicity.1 Both patients and health care providers have questioned whether a third-dose booster in t...
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ARTICLES| VOLUME 398, ISSUE 10303, P843-855, SEPTEMBER 04, 2021 Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial Ly-Mee Yu, Mona Bafadhel, Jienchi Dorward, et al Lancet 2021; 398: 843-855 Summary Background A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospit...
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ORIGINAL ARTICLE Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant Jamie Lopez Bernal, Nick Andrews, Charlotte Gower, et al N Engl J Med 2021; 385:585-594DOI: 10.1056/NEJMoa2108891 Abstract BACKGROUND The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected acros...
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