RECOVERY: World’s Largest COVID-19 Clinical Trial In the UK, the world’s largest clinical trial of potential coronavirus treatments, the Randomised Evaluation of COVID-19 Therapy trial (RECOVERY), is underway. It is aimed at assessing the effects of different treatments, including repurposed and novel drugs, on major outcomes in COVID-19.  You may also like: COVID-19 Will Revolutionise Imaging Practices The trial began on 19 March, and has been progress...

北京协和医院王春耀 ICU Management & Practice, Volume 20 - Issue 1, 2020 Personal Experience With Severe COVID-19 After 66 days in Wuhan COVID-2019 has become a worldwide pandemic. After working in Wuhan as intensive care physicians for 2 months, we have gained significant experience and would like to share our experience about daily care and supportive therapies for severe COVID-19 patients with our colleagues all over the world. The goal is for all of us to ...

ARTICLES|ONLINE FIRST Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial Yasuyuki Kakihana, Osamu Nishida, Takumi Taniguchi, et al. Lancet Respir Med Published:March 31, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30037-0 Summary Background Tachycardia and atrial fibrillation frequently occur in patients bei...

Research Letter May 21, 2020 Postmortem Examination of Patients With COVID-19 Tina Schaller, Klaus Hirschbühl, Katrin Burkhardt, et al JAMA. 2020;323(24):2518-2520. doi:10.1001/jama.2020.8907 Approximately 15% of individuals affected by coronavirus disease 2019 (COVID-19) develop severe disease, and 5% to 6% are critically ill (respiratory failure and/or multiple organ dysfunction or failure).1,2 Severely ill and critically ill patients have a high mortal...

Mechanical Ventilation in COVID-19 There is no specific treatment for COVID-19 patients. For those who develop respiratory failure and are unable to oxygenate with non-invasive methods, critical care doctors are providing supportive therapy. Since the pandemic started, mechanical ventilation has routinely been employed to oxygenate seriously ill COVID-19 patients. Each hospital has developed its own criteria for identifying patients who require mechanical ven...

Original Investigation June 23/30, 2020 Effect of Intraoperative Dexamethasone on Major Complications and Mortality Among Infants Undergoing Cardiac Surgery: The DECISION Randomized Clinical Trial Vladimir Lomivorotov, Igor Kornilov, Vladimir Boboshko, et al JAMA. 2020;323(24):2485-2492. doi:10.1001/jama.2020.8133 Abstract Importance Corticosteroids are widely used in pediatric cardiac surgery to blunt systemic inflammatory response and to...

Research Letter June 15, 2020 Hospital-Wide SARS-CoV-2 Antibody Screening in 3056 Staff in a Tertiary Center in Belgium Deborah Steensels, Els Oris, Laura Coninx, et al JAMA. Published online June 15, 2020. doi:10.1001/jama.2020.11160 Belgium has a high burden of coronavirus disease 2019 (COVID-19), especially the region surrounding the Hospital East-Limburg, a tertiary care center.1 Infection prevention measures were instituted in the hospital ...

ARTICLES|ONLINE FIRST GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study Giacomo De Luca, Giulio Cavalli, Corrado Campochiaro, et al Lancet Rheumatol Published:June 16, 2020 DOI:https://doi.org/10.1016/S2665-9913(20)30170-3 Summary Background Mortality in patients with COVID-19 pneumonia and systemic hyperinflammation is high. We aimed to examine whether mavrilimumab, a...

Research Letter | April 22, 2020 Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection Giacomo Spinato, Cristoforo Fabbris,  Jerry Polesel, et al JAMA. 2020;323(20):2089-2090. doi:10.1001/jama.2020.6771 Since December 2019, a pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally.1 A spectrum of disease severity has been reported, with m...

Effect of Dexamethasone in Hospitalized Patients with COVID-19 – Preliminary Report RECOVERY Collaborative Group ABSTRACT Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing progression to respiratory failure and death. Methods: The Randomised Evaluation of COVID-19 therapy (RECOVERY) trial is a randomized, controlled, open-label, adaptive, platform ...