Original Investigation September 11, 2018 Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial Patrick N. A. Harris, Paul A. Tambyah, David C. Lye, et al JAMA. 2018;320(10):984-994. doi:10.1001/jama.2018.12163 Abstract Importance 背景 Extended-spectrum β-lactamases mediate resistance to third-generation cephalosporins (eg,...

Intensive Care Medicine本周免费阅读 ONLINE FIRST THIS WEEK (FREE ACCESS) ​ What's New in Intensive Care ~ Laurent Brochard and Brian P. Kavanagh. Declaration of conflicts of interest: a ‘crooked’ line towards scientific integrity. What's New in Intensive Care ~ Philippe Durand et al. What’s new in lung ultrasound in the critically ill or injured child. What's New in Intensive Care ~ Chris Beet et al. Intensive care medicine in 2050: preventing harm. Review ~ Perrine Janiau...

News > Medscape Medical News Video Game Training Improves Physicians' Skill in RCT Veronica Hackethal, MD August 28, 2018 Two types of video games may reduce errors in trauma triage in the emergency department (ED), according to a study published online August 27 in the Proceedings of the National Academy of Sciences. 根据8月27日Proceedings of the National Academy of Sciences在线发表的研究显示，两种视频游戏能够减少急诊科(ED)创伤检诊中的错误。 "In a randomized control...

News > Medscape Medical News > Conference News > ESC 2018 TRICS 3: Restrictive Transfusion Appears Safe in CV Surgery August 28, 2018 MUNICH — New research suggests that patients undergoing cardiac surgery may not need a blood transfusion as soon as their blood hemoglobin (Hgb) levels fall below around 8.5 or 9.5 g/dL, and instead, this can wait until the levels drop further. Specifically, among patients with a moderate or higher risk of dying from cardiac surg...

Original Investigation August 28, 2018 Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial Jonathan R. Benger, Kim Kirby, Sarah Black, et al JAMA. 2018;320(8):779-791. doi:10.1001/jama.2018.11597 Abstract Importance 背景 The optimal approach to airway management during out-of-hospital cardiac arrest is unknown. 院外心跳骤停时气管管理最佳方...

Original Investigation August 28, 2018 Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Henry E. Wang, Robert H. Schmicker, Mohamud R. Daya, et al JAMA. 2018;320(8):769-778. doi:10.1001/jama.2018.7044 Abstract Importance 背景 Emergency medical services (EMS) commonly perform endotracheal intubation (ETI) or insertion of supraglottic airway...

ORIGINAL ARTICLE Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery C. David Mazer, Richard P. Whitlock, Dean A. Fergusson, et al N Engl J Med August 26, 2018 DOI: 10.1056/NEJMoa1808561 BACKGROUND 背景 We reported previously that, in patients undergoing cardiac surgery who were at moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal strategy with respect to the composite outcome of death from any caus...

Intensive Care Medicine ONLINE FIRST (FREE ACCESS) Original ~ Fernando G. Zampieri et al. Association of frailty with short-term outcomes, organ support and resource use in critically ill patients. Systematic Review ~ Lina Zhang et al. Association of conflicts of interest with the results and conclusions of goal-directed hemodynamic therapy research: a systematic review with meta-analysis. Original ~ Gerard Moreno et al. Corticosteroid treatment in critically ill patients ...

ORIGINAL ARTICLE Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care Lia Bally, Hood Thabit, Sara Hartnell, et al N Engl J Med 2018; 379:547-556 DOI: 10.1056/NEJMoa1805233 Abstract BACKGROUND 背景 In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in patients with type 1 diabetes. We want...

Articles Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial Hunter B Moore, Ernest E Moore, Michael P Chapman, et al Lancet 2018; 392: 283-291 Summary Background 背景 Plasma is integral to haemostatic resuscitation after injury, but the timing of administration remains controversial. Anticipating approval of lyophilised plasma by the US Food and Drug Administration, the US Department of Defe...