Intensive Care Medicine ONLINE FIRST THIS WEEK(FREE ACCESS) Original ~ Maryna Masyuk - Prognostic relevance of serum lactate kinetics in critically ill patients Systematic Review ~ Leona Bannon - The effectiveness of non-pharmacological interventions in reducing the incidence and duration of delirium in critically ill patients: a systematic review and meta-analysis Editorial ~ Peter Pickkers - Treatment with a polymyxin B filter to capture endot...

Assessment of vocal cord movement by ultrasound in the ICU Zhengshang Ruan, Rongrong Ren, Wenwen Dong, et al Intensive Care Med 2018 Abstract Purpose 目的 Ultrasound can be used to non-invasively and rapidly examine airway conditions, but vocal cord visualization with the traditional approaches is poor. Our aim was to compare the accuracies of front-side transverse-axis ultrasound (FTU), lateral-side longitudinal-axis ultrasound (LLU), and the combination of both approac...

Alleviating inflammation: new inhibitor could treat ARDS in future A newly discovered OGG1 inhibitor has been found to decrease lung inflammation in mice and could in future treat acute respiratory distress syndrome (ARDS), sepsis and autoimmune diseases. The six-year study, by an international team of researchers, is published in Science. The research shows that the OGG1 protein, which is involved in repairing oxidated DNA, signals inflammation. The researchers set out t...

Intensive Care Medicine Erythromycin versus metoclopramide for post-pyloric spiral nasoenteric tube placement: a randomized non-inferiority trial Bei Hu, Xin Ouyang, Liming Lei, et al Intensive Care Med 2018 Abstract Purpose 目的 To determine whether erythromycin is non-inferior to metoclopramide in facilitating post-pyloric placement of self-propelled spiral nasoenteric tubes (NETs) in critically ill patients. 验证红霉素辅助重症患者自推进式螺旋型鼻肠管幽门后置管的...

Original Investigation December 4, 2018 Association of Oral Anticoagulants and Proton Pump Inhibitor Cotherapy With Hospitalization for Upper Gastrointestinal Tract Bleeding Wayne A. Ray, Cecilia P. Chung, Katherine T. Murray, et al JAMA. 2018;320(21):2221-2230. doi:10.1001/jama.2018.17242 Abstract Importance 背景 Anticoagulant choice and proton pump inhibitor (PPI) cotherapy could affect the risk of upper gastrointestinal tract bleeding, a frequent and potential...

Head To Head Patient commentary: Stop hyping artificial intelligence—patients will always need human doctors Michael Mittelman, Sarah Markham, Mark Taylor BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4669 (Published 07 November 2018) Cite this as: BMJ 2018;363:k4669 If regulated and well implemented, machines that learn have the potential to bring huge benefit to patients, but who wants to receive a terminal diagnosis from a robot? ask Michael Mittelman, Sarah Markham,...

ORIGINAL ARTICLE One-Year Outcomes after PCI Strategies in Cardiogenic Shock Holger Thiele, Ibrahim Akin, Marcus Sandri, et al N Engl J Med 2018; 379:1699-1710 DOI: 10.1056/NEJMoa1808788 Abstract BACKGROUND 背景 Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found to be lower with percutane...

Deep learning algorithms for detection of critical findings in head CT scans: a retrospective study Sasank Chilamkurthy, Rohit Ghosh, Swetha Tanamala, et al Lancet 2018; 392: 2388-2396 Summary Background 背景 Non-contrast head CT scan is the current standard for initial imaging of patients with head trauma or stroke symptoms. We aimed to develop and validate a set of deep learning algorithms for automated detection of the following key findings from these scans: intracra...

Intensive Care Medicine本周免费阅读 ONLINE FIRST THIS WEEK (FREE ACCESS) Original ~ Pichoy Danial. Percutaneous versus surgical femoro-femoral veno-arterial ECMO: a propensity score matched study . Original ~ Pekka Jakkula. Targeting low-normal or high-normal mean arterial pressure after cardiac arrest and resuscitation: a randomised pilot trial. Editorial ~ Pierre Delaere. Tracheal transplantation. From the Inside ~ Luca Carenzo. This is not a drill. Imaging in Intensive ...

Head To Head Could artificial intelligence make doctors obsolete? Jörg Goldhahn, Vanessa Rampton, Giatgen A Spinas BMJ 2018; 363 doi: https://doi.org/10.1136/bmj.k4563 (Published 07 November 2018) Cite this as: BMJ 2018;363:k4563 Machines that can learn and correct themselves already perform better than doctors at some tasks, says Jörg Goldhahn, but Vanessa Rampton and Giatgen A Spinas maintain that machines will never be able to replicate the inter-relational quality of ...