ARTICLES|ONLINE FIRST Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial JoAnn Lindenfeld, Michael R Zile, Akshay S Desai, et al Lancet Published:August 27, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)01754-2 Summary Background Previous studies have suggested that haemodynamic-guided management using an implantable pulmonary artery pressure monitor reduces heart failure hospitalisations in patients with moderatel...

ORIGINAL ARTICLE Early Convalescent Plasma for High-Risk Outpatients with Covid-19 Frederick K. Korley, Valerie Durkalski-Mauldin, Sharon D. Yeatts, et al N Engl J Med August 18, 2021DOI: 10.1056/NEJMoa2103784 Abstract BACKGROUND Early administration of convalescent plasma obtained from blood donors who have recovered from coronavirus disease 2019 (Covid-19) may prevent disease progression in acutely ill, high-risk patients with Covid-19. METHODS I...

ICU Management & Practice, Volume 20 - Issue 3, 2020 Infographic Problems associated with ageing, complications of critical illness in the elderly patient, and an overview of the gaps in the treatment of critically ill older adults.

Research Letter August 13, 2021 Change in Saliva RT-PCR Sensitivity Over the Course of SARS-CoV-2 Infection Zion Congrave-Wilson, Yesun Lee, Jaycee Jumarang, et al JAMA. Published online August 13, 2021. doi:10.1001/jama.2021.13967 While real-time reverse transcriptase–polymerase chain reaction (RT-PCR) on nasopharyngeal swabs is the current standard for SARS-CoV-2 detection, saliva is an attractive alternative...

ARTICLES|ONLINE FIRST Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial PRISM trial group Lancet Respir Med Published:June 18, 2021 DOI: https://doi.org/10.1016/S2213-2600(21)00089- Summary Background Respiratory complications are an important cause of postoperative morbidity. We aimed to investigate whether continuou...

ARTICLES| VOLUME 9, ISSUE 8, P863-872, AUGUST 01, 2021 Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial Axel Bauer, Michael Schreinlechner, Nikolay Sappler, et al Lancet Respir Med 2021; 9: 863-872 DOI:https://doi.org/10.1016/S2213-2600(21)00214-9 Summary Background SARS-CoV-2 entry in human cells depends on angiotens...

ORIGINAL ARTICLE Abelacimab for Prevention of Venous Thromboembolism Peter Verhamme, B. Alexander Yi, Annelise Segers, et al N Engl J Med 2021; 385:609-617DOI: 10.1056/NEJMoa2105872 Abstract BACKGROUND The role of factor XI in the pathogenesis of postoperative venous thromboembolism is uncertain. Abelacimab is a monoclonal antibody that binds to factor XI and locks it in the zymogen (inactive precursor) conformation. METHODS In this open-label, par...

CORRESPONDENCE Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients Victoria G. Hall, Victor H. Ferreira, Terrance Ku, et al N Engl J Med August 11, 2021DOI: 10.1056/NEJMc2111462 TO THE EDITOR: In organ-transplant recipients, the standard two-dose vaccination strategy for coronavirus disease 2019 (Covid-19) has suboptimal immunogenicity.1 Both patients and health care providers have questioned whether a third-dose booster in t...

ARTICLES| VOLUME 398, ISSUE 10303, P843-855, SEPTEMBER 04, 2021 Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial Ly-Mee Yu, Mona Bafadhel, Jienchi Dorward, et al Lancet 2021; 398: 843-855 Summary Background A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospit...

ORIGINAL ARTICLE Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant Jamie Lopez Bernal, Nick Andrews, Charlotte Gower, et al N Engl J Med 2021; 385:585-594DOI: 10.1056/NEJMoa2108891 Abstract BACKGROUND The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected acros...