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ARTICLES| VOLUME 9, ISSUE 12, P1427-1438, DECEMBER 01, 2021 Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial Jozefien Declercq, Karel F A Van Damme, Elisabeth De Leeuw, et al Lancet Respir Med 2021; 9: 1427-1438 Summary Background Infections with SARS-CoV-2 continue to cause significant morbidity and mortality. Interleukin (IL)-1 and IL-6 ...
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ARTICLES| VOLUME 9, ISSUE 12, P1419-1426, DECEMBER 01, 2021 Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Respir Med 2021; 9: 1419-1426 Summary Background Colchicine has been proposed as a treatment for COVID-19 based on its anti-inflammatory actions. We aimed to evaluate the efficacy and safety of colchicine in patients admitte...
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Original Investigation December 21, 2021 Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial Silje Watterdal Syversen, Kristin Kaasen Jørgensen, Guro Løvik Goll, et al JAMA. 2021;326(23):2375-2384. doi:10.1001/jama.2021.21316 Abstract Importance  Proactive therapeutic drug monitoring (TDM...
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ARTICLES|ONLINE FIRST Rivaroxaban versus no anticoagulation for post-discharge thromboprophylaxis after hospitalisation for COVID-19 (MICHELLE): an open-label, multicentre, randomised, controlled trial Eduardo Ramacciotti, Leandro Barile Agati, Daniela Calderaro, et al Lancet Published:December 15, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)02392-8 Summary Background Patients hospitalised with COVID-19 are at risk for thrombotic events after disch...
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ARTICLES| VOLUME 399, ISSUE 10321, P237-248, JANUARY 15, 2022 Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial Scott A Halperin, Lingyun Ye, Donna MacKinnon-Cameron, et al Lancet 2022; 399: 237-248 Summary Background ...
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Original Investigation December 20, 2021 Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial Ting Li, Jun Li, Liyong Yuan, et al JAMA. Published online December 20, 2021. doi:10.1001/jama.2021.22647 Abstract Importance  In adults undergoing hip fracture surgery, regional anesthesia may reduce postoperative delirium, but there is ...
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ARTICLES|ONLINE FIRST Immunogenicity, safety, and reactogenicity of heterologous COVID-19 primary vaccination incorporating mRNA, viral-vector, and protein-adjuvant vaccines in the UK (Com-COV2): a single-blind, randomised, phase 2, non-inferiority trial Arabella S V Stuart, Robert H Shaw, Xinxue Liu, et al Lancet Published:December 06, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)02718-5 Summary Background Given the importance of flexible use of di...
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ARTICLES| VOLUME 398, ISSUE 10318, P2258-2276, DECEMBER 18, 2021 Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial Alasdair P S Munro, Leila Janani, Victoria Cornelius, et al Lancet 2021; 398: 2258-2276 Summary Background Few data exist on the comparative safety and immunogenicity of differen...
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Original Investigation December 13, 2021 Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial Peter A. Dargaville, C. Omar F. Kamlin, Francesca Orsini, et al JAMA. Published online December 13, 2021. doi:10.1001/jama.2021.21892 Abstract Importance  The benefits of surfactant administrati...
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Original Investigation Caring for the Critically Ill PatientDecember 8, 2021 Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial Brian E. Driver, Matthew W. Semler, Wesley H. Self, et al JAMA. Published online December 8, 2021. doi:10.1001/jama.2021.22002 Abstract Importance  For critically i...
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