Original Investigation  March 7, 2023 Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Babak J. Orandi, M. Chandler McLeod, Paul A. MacLennan, et al JAMA. 2023;329(9):735-744. doi:10.1001/jama.2023.1080 Key Points Question  Was the US Food and Drug Administration (FDA) mandate to limit acetaminophen (paracetamol) to ...

COMMENT|ONLINE FIRST PANORAMIC: important insights into molnupiravir use in COVID-19 Michael R Kidd, Paul M Kelly Lancet Published: December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02593-4 Oral antivirals have been an important addition to efforts to minimise adverse COVID-19 outcomes in individuals at high risk. Although no head-to-head comparisons of the widely available treatments molnupiravir and nirmatrelvir–ritonavir have been published, ea...

Original Investigation  October 26, 2022 Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis Naomi E. Hammond, John Myburgh, Ian Seppelt, et al JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.19709 Key Points Question  In adults receiving mechanical ventilation in the in...

Original Investigation  Caring for the Critically Ill Patient October 26, 2022 Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial The SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.17927 Key Points Quest...

Comment Intravenous thrombolysis before thrombectomy for acute ischaemic stroke Pooja Khatri Lancet 2022; 400: 76-78 https://doi.org/10.1016/S0140-6736(22)01286-7 Before endovascular therapy, patients with ischaemic stroke due to occlusion of large arteries were treated with only intravenous thrombolysis, specifically alteplase. Intravenous thrombolysis recanalised about 25% of occluded large arteries, resulting in fewer than 30% of patients achieving funct...

Original Investigation Caring for the Critically Ill PatientMarch 8, 2022 Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial The ICU-RESUS and Eunice Kennedy Shriver National Institute of Child Health; and Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups JAMA. 2022;327(10)...

CORRESPONDENCE Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2 Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, et al N Engl J Med March 9, 2022DOI: 10.1056/NEJMc2201933 TO THE EDITOR: The omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease 2019 (Covid-19), has spread rapidly around the world and has already become the predominant variant circu...

ARTICLES|ONLINE FIRST Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis Antimicrobial Resistance Collaborators Lancet Published:January 19, 2022DOI:https://doi.org/10.1016/S0140-6736(21)02724-0 Summary Background Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs fo...

Dear Bin, 亲爱的杜斌大夫 Dear Wang, 亲爱的王春耀大夫 I guess that your Department of Emergency is very busy with the corona virus epidemy. 我想你们医院的急诊室正忙于应对冠状病毒的疫情。 What is implemented in China to fight against the Corona virus epidemy is really impressive for the International Medical Community. We are totally confident that your country will be successful to control the epidemy. We wish you a rapid and complete success. 中国为抗击...

2019-4-29 （十一） 我的家庭教育包括两部分，妈妈教我学习古文，认识中国固有的文化和传统的历史，弥补了学校教育的一大缺陷。爸爸的书橱为我提供课外读物的重要来源。爸爸书橱虽小，对我很有吸收力。我能不受约束地享有着最自由的时间。爸爸藏书不多，很杂。不知为什么在上世纪30年代，他从旧书店买回来几本法国经典小说。其中有两本，《法国短篇小说集》和《悲惨世界》原文版，至今仍保存着。虽然爸爸曾经参加过业余的短期初级法语学习，他没有能力阅读名著的原文版。他显然也不是为我准备，因为我在193...