Original Investigation  Caring for the Critically Ill Patient October 25, 2023 Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial Richard K. Albert, Gregory J. Jurkovich, John Connett, et al JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.21739 Key Points Question  Does adding sigh breaths to the usual care of trauma patients receiving mechanical ventilation increase ventilator-free d...

Original Investigation  Caring for the Critically Ill Patient October 12, 2023 Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial Ross Davenport, Nicola Curry, Erin E. Fox, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.21019 Key Points Question  Does transfusion of early and empirical high-dose cryoprecipitate in addition to stand...

Original Investigation  March 7, 2023 Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Babak J. Orandi, M. Chandler McLeod, Paul A. MacLennan, et al JAMA. 2023;329(9):735-744. doi:10.1001/jama.2023.1080 Key Points Question  Was the US Food and Drug Administration (FDA) mandate to limit acetaminophen (paracetamol) to ...

COMMENT|ONLINE FIRST PANORAMIC: important insights into molnupiravir use in COVID-19 Michael R Kidd, Paul M Kelly Lancet Published: December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02593-4 Oral antivirals have been an important addition to efforts to minimise adverse COVID-19 outcomes in individuals at high risk. Although no head-to-head comparisons of the widely available treatments molnupiravir and nirmatrelvir–ritonavir have been published, ea...

Original Investigation  October 26, 2022 Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis Naomi E. Hammond, John Myburgh, Ian Seppelt, et al JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.19709 Key Points Question  In adults receiving mechanical ventilation in the in...

Original Investigation  Caring for the Critically Ill Patient October 26, 2022 Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial The SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.17927 Key Points Quest...

Comment Intravenous thrombolysis before thrombectomy for acute ischaemic stroke Pooja Khatri Lancet 2022; 400: 76-78 https://doi.org/10.1016/S0140-6736(22)01286-7 Before endovascular therapy, patients with ischaemic stroke due to occlusion of large arteries were treated with only intravenous thrombolysis, specifically alteplase. Intravenous thrombolysis recanalised about 25% of occluded large arteries, resulting in fewer than 30% of patients achieving funct...

Original Investigation Caring for the Critically Ill PatientMarch 8, 2022 Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial The ICU-RESUS and Eunice Kennedy Shriver National Institute of Child Health; and Human Development Collaborative Pediatric Critical Care Research Network Investigator Groups JAMA. 2022;327(10)...

CORRESPONDENCE Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2 Emi Takashita, Noriko Kinoshita, Seiya Yamayoshi, et al N Engl J Med March 9, 2022DOI: 10.1056/NEJMc2201933 TO THE EDITOR: The omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is responsible for coronavirus disease 2019 (Covid-19), has spread rapidly around the world and has already become the predominant variant circu...

ARTICLES|ONLINE FIRST Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis Antimicrobial Resistance Collaborators Lancet Published:January 19, 2022DOI:https://doi.org/10.1016/S0140-6736(21)02724-0 Summary Background Antimicrobial resistance (AMR) poses a major threat to human health around the world. Previous publications have estimated the effect of AMR on incidence, deaths, hospital length of stay, and health-care costs fo...