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[JAMA发表述评]:解决持续或间断输注β-内酰胺类抗生素治疗脓毒症的难题已关闭评论
Editorial  June 12, 2024 Resolving the Dilemma on Continuous vs Intermittent β-Lactam Antibiotics in Sepsis W. Joost Wiersinga, Michiel A. van Agtmael JAMA. Published online June 12, 2024. doi:10.1001/jama.2024.10168 The Surviving Sepsis Campaign guidelines recommend that adults with sepsis or septic shock should receive prolonged infusion of β-lactams (after an initial bolus) vs conventional intermittent infusion.1 However, this is only...
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[JAMA Netw Open发表论文]:美国呼吸道合胞病毒、新冠病毒及流感病毒感染成年住院患者的疾病严重程度已关闭评论
Original Investigation  Infectious Diseases April 4, 2024 Severity of Respiratory Syncytial Virus vs COVID-19 and Influenza Among Hospitalized US Adults Diya Surie, Katharine A. Yuengling, Jennifer DeCuir, et al JAMA Netw Open. 2024;7(4):e244954. doi:10.1001/jamanetworkopen.2024.4954 Key Points Question  How does disease severity of respiratory syncytial virus (RSV) compare with COVID-19 and influenza among adults hospitalized...
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[Heptatology发表论文]:氨甲环酸治疗肝硬化患者的上消化道出血已关闭评论
ORIGINAL ARTICLE Tranexamic acid in upper gastrointestinal bleed in patients with cirrhosis - a randomized controlled trial Kumar, Manoj, Venishetty, Shantan, Jindal, Ankur et al Hepatology ():10.1097/HEP.0000000000000817, March 5, 2024. | DOI: 10.1097/HEP.0000000000000817 Abstract Background and aims:  Patients with Child-Turcotte-Pugh (CTP) class B and C cirrhosis with upper GI bleeding (UGIB) have systemic as well as localized (in the mucosa of o...
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[JAMA发表论文]:创伤患者的叹气通气已关闭评论
Original Investigation  Caring for the Critically Ill Patient October 25, 2023 Sigh Ventilation in Patients With Trauma: The SiVent Randomized Clinical Trial Richard K. Albert, Gregory J. Jurkovich, John Connett, et al JAMA. Published online October 25, 2023. doi:10.1001/jama.2023.21739 Key Points Question  Does adding sigh breaths to the usual care of trauma patients receiving mechanical ventilation increase ventilator-free d...
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[JAMA发表论文]:早期经验性大剂量冷沉淀治疗创伤后出血已关闭评论
Original Investigation  Caring for the Critically Ill Patient October 12, 2023 Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury: The CRYOSTAT-2 Randomized Clinical Trial Ross Davenport, Nicola Curry, Erin E. Fox, et al JAMA. Published online October 12, 2023. doi:10.1001/jama.2023.21019 Key Points Question  Does transfusion of early and empirical high-dose cryoprecipitate in addition to stand...
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[JAMA发表论文]:FDA限制对乙酰氨基酚与阿片联合处方的命令及随后住院及急性肝衰的相关性已关闭评论
Original Investigation  March 7, 2023 Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Babak J. Orandi, M. Chandler McLeod, Paul A. MacLennan, et al JAMA. 2023;329(9):735-744. doi:10.1001/jama.2023.1080 Key Points Question  Was the US Food and Drug Administration (FDA) mandate to limit acetaminophen (paracetamol) to ...
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[Lancet发表述评]:PANORAMIC:莫努匹韦用于治疗新冠肺炎的已关闭评论
COMMENT|ONLINE FIRST PANORAMIC: important insights into molnupiravir use in COVID-19 Michael R Kidd, Paul M Kelly Lancet Published: December 22, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)02593-4 Oral antivirals have been an important addition to efforts to minimise adverse COVID-19 outcomes in individuals at high risk. Although no head-to-head comparisons of the widely available treatments molnupiravir and nirmatrelvir–ritonavir have been published, ea...
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[JAMA发表论文]:选择性胃肠道去污染与ICU接受机械通气患者住院病死率的相关性:一项系统回顾与meta分析已关闭评论
Original Investigation  October 26, 2022 Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis Naomi E. Hammond, John Myburgh, Ian Seppelt, et al JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.19709 Key Points Question  In adults receiving mechanical ventilation in the in...
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[JAMA发表论文]:选择性胃肠道去污染对接受机械通气的危重病患者住院病死率的影响已关闭评论
Original Investigation  Caring for the Critically Ill Patient October 26, 2022 Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial The SuDDICU Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group JAMA. Published online October 26, 2022. doi:10.1001/jama.2022.17927 Key Points Quest...
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[Lancet发表述评]:急性缺血性卒中取栓前静脉溶栓已关闭评论
Comment Intravenous thrombolysis before thrombectomy for acute ischaemic stroke Pooja Khatri Lancet 2022; 400: 76-78 https://doi.org/10.1016/S0140-6736(22)01286-7 Before endovascular therapy, patients with ischaemic stroke due to occlusion of large arteries were treated with only intravenous thrombolysis, specifically alteplase. Intravenous thrombolysis recanalised about 25% of occluded large arteries, resulting in fewer than 30% of patients achieving funct...
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