Original Investigation
Surgery
August 2, 2024
Surgical Repair vs Splenectomy in Patients With Severe Traumatic Spleen Injuries
Dominik A. Jakob, Martin Müller, Apostolos Kolitsas, et al
JAMA Netw Open. 2024;7(8):e2425300. doi:10.1001/jamanetworkopen.2024.25300
Question Is splenic repair associated with better outcomes compared with splenectomy in patients with traumatic splenic injury undergoing laparotomy?
Findings In this cohort study of 11 247 patients, splenic repair was independently associated with lower mortality compared with splenectomy during laparotomy.
Meaning These findings suggest that efforts to preserve the spleen should be made in selected cases of patients with traumatic splenic injuries undergoing laparotomy.
Abstract
Importance The spleen is often removed in laparotomy after traumatic abdominal injury, with little effort made to preserve the spleen.
Objective To explore the association of surgical management (splenic repair vs splenectomy) with outcomes in patients with traumatic splenic injuries undergoing laparotomy and to determine whether splenic repair is associated with lower mortality compared with splenectomy.
Design, Setting, and Participants This is a trauma registry–based cohort study using the American College of Surgeons Trauma Quality Improvement Program database from January 2013 to December 2019. Participants included adult patients with severe splenic injuries (Abbreviated Injury Scale [AIS] grades 3-5) undergoing laparotomy after traumatic injury within 6 hours of admission. Data analysis was performed from April to August 2023.
Exposures Splenic repair vs splenectomy in patients with severe traumatic splenic injury.
Main Outcomes and Measures The primary outcome was in-hospital mortality. Outcomes were compared using different statistical approaches, including 1:1 exact matching with consecutive conditional logistic regression analysis as the primary analysis and multivariable logistic regression, propensity score matching, and inverse-probability weighting as sensitivity analyses.
Results A total of 11 247 patients (median [IQR] age, 35 [24-52] years; 8179 men [72.7%]) with a severe traumatic splenic injury undergoing laparotomy were identified. Of these, 10 820 patients (96.2%) underwent splenectomy, and 427 (3.8%) underwent splenic repair. Among patients who underwent an initial splenic salvage procedure, 23 (5.3%) required a splenectomy during the subsequent hospital stay; 400 patients with splenic preservation were matched with 400 patients who underwent splenectomy (matched for age, sex, hypotension, trauma mechanism, AIS spleen grade, and AIS groups [0-2, 3, and 4-5] for head, face, neck, thorax, spine, and lower and upper extremity). Mortality was significantly lower in the splenic repair group vs the splenectomy group (26 patients [6.5%] vs 51 patients [12.8%]). The association of splenic repair with lower mortality was subsequently verified by conditional regression analysis (adjusted odds ratio, 0.4; 95% CI, 0.2-0.9; P = .03). Multivariable logistic regression, propensity score matching, and inverse-probability weighting confirmed this association.
Conclusions and Relevance In this retrospective cohort study, splenic repair was independently associated with lower mortality compared with splenectomy during laparotomy after traumatic splenic injury. These findings suggest that efforts to preserve the spleen might be indicated in selected cases of severe splenic injuries.
