Original Investigation
Nephrology
Early Nephrology Consultation and Acute Kidney Injury in Hospitalized Patients: A Randomized Clinical Trial
Matthew M. Churpek, Aiman Fatima, Olasunkanmi Anjorin, et al
JAMA Netw Open 2026;9;(7):e2622554. doi:10.1001/jamanetworkopen.2026.22554
Question Among inpatients at risk for severe acute kidney injury (AKI), does an early structured nephrology consultation, triggered by a machine-learning risk score, lead to smaller peak changes in serum creatinine (SCr)?
Findings In this randomized clinical trial of 180 patients at high risk for AKI, an early nephrology consultation triggered by a machine-learning model did not reduce the peak change in SCr. Consultation recommendations were less likely to be followed for patients in the early consultation arm compared with the usual care arm.
Meaning The findings of this study suggest that early nephrology consultations do not prevent rises in peak SCr among hospitalized patients at risk for severe AKI.
Abstract
Objective To determine whether a structured early nephrology consultation triggered by a machine-learning acute kidney injury (AKI) risk score (electronic signal to prevent AKI [ESTOP-AKI]) in patients at high risk for stage 2 AKI improves patient outcomes.
Design, Setting, and Participants This randomized clinical trial was conducted at the University of Chicago, Illinois, from March 13, 2019, to August 21, 2024, in hospitalized patients with no serum creatinine (SCr)–based AKI and an ESTOP-AKI score more than 0.01.
Intervention Patients were randomized to receive a structured early nephrology consultation (ENC) from an attending nephrologist or usual care (UC). The ENC included an in-person assessment and recommendations regarding volume status, kidney perfusion, medication dosing and selection, electrolytes, nutritional needs, and further testing. Patients in the UC arm only received a nephrology consultation when clinically requested by the primary team.
Main Outcomes and Measures The primary outcome was the peak change in SCr from enrollment (ΔSCr) during the 7-day follow-up. Secondary outcomes included development of AKI, need for kidney replacement therapy, and inpatient and 90-day mortality.
Results Of the 180 patients randomized (median [IQR] age, 62.5 [50.0-71.0] years; 102 males [56.7%]), 89 (49.4%) received ENC, and 91 (50.6%) received UC. There was no significant adjusted mean (SE) difference in the 7-day ΔSCr between the ENC and UC groups, adjusted for the ESTOP risk group (0.04 [0.07] mg/dL vs −0.03 [0.07] mg/dL; P = .30), among the 70 patients (38.9%) in the development of stage 1 or higher AKI (37 [42%] vs 33 [36%]; P = .47) or among the 29 patients (16.1%) with stage 2 or higher AKI (17 [19%] vs 12 [13%]; P = .28). During the study period, there were 121 ENC consultations containing 270 recommendations compared with 19 UC consultations and 36 recommendations. Medication dosage and discontinuation, diuretics or fluids, and vasopressor recommendations were more likely to be completely followed in the UC arm (15 of 22 [68%]) compared with in the ENC arm (48 of 116 [41%]). Over the 90-day follow-up, there was no significant difference in readmission rates (ENC: 30 [34.1%] vs UC: 40 [44.4%]; P = .21) or 90-day mortality (ENC: 13 [14.8%] vs UC: 17 [18.7%]; P = .62) between the ENC and UC arms.
Conclusions and Relevance In this randomized clinical trial of structured ENC triggered by a machine-learning AKI risk score, there was no difference in ΔSCr. AKI consultation recommendations were not followed the majority of time; whether increasing adherence to recommendations could improve outcomes deserves further study.
Trial Registration ClinicalTrials.gov Identifier: NCT03590028
