Original Investigation  November 29, 2023 Scalability and Sustainability of a Surgical Infection Prevention Program in Low-Income Environments Nichole Starr, Natnael Gebeyehu, Maia R. Nofal, et al JAMA Surg. Published online November 29, 2023. doi:10.1001/jamasurg.2023.6033 Key Points Question  Is a quality improvement program to reduce surgical site infections in low-income settings, modified t...

ARTICLES|ONLINE FIRST Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales The HDR UK COALESCE Consortium Lancet Published:January 15, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02467-4 Summary Background Undervaccination (receiving fewer than the recommended number of SARS-CoV-2 vaccine doses) could be associated with increased risk of severe COVID-19 outcomes—ie...

ORIGINAL ARTICLE CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up Fabian Müller, Jule Taubmann, Laura Bucci, et al N Engl J Med 2024; 390:687-700DOI: 10.1056/NEJMoa2308917 Abstract BACKGROUND Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these diseases through ...

Research Letter  Health Care Reform August 28, 2023 Career Plans of Internal Medicine Residents From 2019 to 2021 Neha Paralkar, Nancy LaVine, Saoirse Ryan, et al JAMA Intern Med. 2023;183(10):1166-1167. doi:10.1001/jamainternmed.2023.2873 Shortages of primary care clinicians are projected by numerous groups; the Association of American Medical Colleges projects a shortage of up to 48 000 primary care physicians by 2032.1 As internal medicine (...

Original Investigation  January 10, 2024 Faculty Entrustment and Resident Entrustability Jessica K. Millar, Niki Matusko, Julie Evans, et al JAMA Surg. Published online January 10, 2024. doi:10.1001/jamasurg.2023.6915 Key Points Question  What factors are associated with resident entrustability behaviors in the operating room? Findings  In this cross-sectional study, resident and faculty intraoperative behaviors were...

Viewpoint  January 11, 2024 T-Cell Lymphoma From CAR T-Cell Therapy—A New Safety Notice Vinay Prasad JAMA. Published online January 11, 2024. doi:10.1001/jama.2023.27885 On November 28, 2023, a concerning safety signal was announced by the US Food and Drug Administration (FDA) Center for Biologics Evaluation and Research. Several patients undergoing chimeric antigen receptor (CAR) T-cell therapy for pediatric acute lymphocytic leukemia, non-H...

Guide to Statistics and Methods  Surgical Education Research January 3, 2024 Practical Guide to Common Flaws With Surgical Education Research Dimitrios Stefanidis, Laura Torbeck, Amy H. Kaji JAMA Surg. Published online January 3, 2024. doi:10.1001/jamasurg.2023.6675 Introduction Over the past 2 decades, surgical education literature has seen tremendous growth driven by changes in graduate medical education,...

Original Investigation  January 8, 2024 Population-Based Trends in Complexity of Hospital Inpatients Hiten Naik, Tyler M. Murray, Mayesha Khan, et al JAMA Intern Med. Published online January 8, 2024. doi:10.1001/jamainternmed.2023.7410 Key Points Question  Are hospital inpatients becoming more complex over time? Findings  In this cohort study of 3.4 million nonelective hospitalizations in British Columbia, Canada, m...

Original Investigation  January 16, 2024 Analysis of Breast Cancer Mortality in the US—1975 to 2019 Jennifer L. Caswell-Jin, Liyang P. Sun, Diego Munoz, et al JAMA. 2024;331(3):233-241. doi:10.1001/jama.2023.25881 Key Points Question  What are the relative associations of breast cancer screening, treatment of stage I to III breast cancer, and treatment of metastatic breast cancer with improved breast cancer mortality in the US be...

Original Investigation  January 16, 2024 Default Palliative Care Consultation for Seriously Ill Hospitalized Patients: A Pragmatic Cluster Randomized Trial Katherine R. Courtright, Vanessa Madden, Brian Bayes, et al JAMA. 2024;331(3):224-232. doi:10.1001/jama.2023.25092 Key Points Question  Does ordering palliative care by default (allowing opt-out) increase consultation and improve clinical outcomes? Findings  In th...