Research Letter  December 28, 2023 Lifting of Embargoes to Data Sharing in Clinical Trials Published in Top Medical Journals Maximilian Siebert, John P. A. Ioannidis JAMA. 2024;331(4):354-355. doi:10.1001/jama.2023.25394 Data sharing in clinical trials enhances trust and reproducibility and allows secondary analyses.1 However, sharing of clinical trials data is the exception rather than the rule2 and is often limited by embargoes, which const...

ARTICLES|ONLINE FIRST Risk factors for COVID-19-associated pulmonary aspergillosis: a systematic review and meta-analysis Francesca Gioia, Laura N Walti, Ani Orchanian-Cheff, et al Lancet Published: January 04, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00408-3 Summary Background COVID-19-associated pulmonary aspergillosis (CAPA) has been reported to be an emerging and potentially fatal complication of severe COVID-19. However, risk factors for C...

ARTICLES|ONLINE FIRST The effectiveness of COVID-19 vaccines to prevent long COVID symptoms: staggered cohort study of data from the UK, Spain, and Estonia Martí Català, Núria Mercadé-Besora, Raivo Kolde, et al Lancet Published: January 11, 2024 DOI:https://doi.org/10.1016/S2213-2600(23)00414-9 Summary Background Although vaccines have proved effective to prevent severe COVID-19, their effect on preventing long-term symptoms is not yet fully understoo...

ARTICLES|ONLINE FIRST Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial Claire Dahyot-Fizelier, Sigismond Lasocki, Thomas Kerforne, et al Lancet Respir Med Published: January 20, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00471-X Summary Background Patients with acute brain injury are at high risk of venti...

ARTICLES|ONLINE FIRST The effect of computerised decision support alerts tailored to intensive care on the administration of high-risk drug combinations, and their monitoring: a cluster randomised stepped-wedge trial Tinka Bakker, Joanna E Klopotowska, Dave A Dongelmans, et al Lancet Published:January 20, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02465-0 Summary Background Drug–drug interactions (DDIs) can harm patients admitted to the intensive ...

ORIGINAL ARTICLE Biomarker Changes during 20 Years Preceding Alzheimer’s Disease Jianping Jia, Yuye Ning, Meilin Chen, et al N Engl J Med 2024; 390:712-722DOI: 10.1056/NEJMoa2310168 Abstract BACKGROUND Biomarker changes that occur in the period between normal cognition and the diagnosis of sporadic Alzheimer’s disease have not been extensively investigated in longitudinal studies. METHODS We conducted a multicenter, nested case–control study of Alz...

ARTICLES| VOLUME 22, ISSUE 12, P1140-1149, DECEMBER 2023Download Full Issue Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials Rustam Al-Shahi Salman, Jacqueline Stephen, Prof Jayne F Tierney, et al. Lancet Neuron 2023; 22: 1140-1149 Published:October 12, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00315-0 Summar...

Original Investigation  November 29, 2023 Scalability and Sustainability of a Surgical Infection Prevention Program in Low-Income Environments Nichole Starr, Natnael Gebeyehu, Maia R. Nofal, et al JAMA Surg. Published online November 29, 2023. doi:10.1001/jamasurg.2023.6033 Key Points Question  Is a quality improvement program to reduce surgical site infections in low-income settings, modified t...

ARTICLES|ONLINE FIRST Undervaccination and severe COVID-19 outcomes: meta-analysis of national cohort studies in England, Northern Ireland, Scotland, and Wales The HDR UK COALESCE Consortium Lancet Published:January 15, 2024 DOI:https://doi.org/10.1016/S0140-6736(23)02467-4 Summary Background Undervaccination (receiving fewer than the recommended number of SARS-CoV-2 vaccine doses) could be associated with increased risk of severe COVID-19 outcomes—ie...

ORIGINAL ARTICLE CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up Fabian Müller, Jule Taubmann, Laura Bucci, et al N Engl J Med 2024; 390:687-700DOI: 10.1056/NEJMoa2308917 Abstract BACKGROUND Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these diseases through ...