ORIGINAL ARTICLE Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria Régis Peffault de Latour, Alexander Röth, Austin G. Kulasekararaj, et al N Engl J Med 2024; 390:994-1008DOI: 10.1056/NEJMoa2308695 Abstract BACKGROUND Persistent hemolytic anemia and a lack of oral treatments are challenges for patients with paroxysmal nocturnal hemoglobinuria who have received anti-C5 therapy or have not received complement inhibitors. Iptacopan, a first-...

Chest Infections: Original Research Using Trajectories of Bedside Vital Signs to Identify COVID-19 Subphenotypes Sivasubramanium V. Bhavani, Chad Robichaux, Philip A. Verhoef, et al Chest 2024; 165: 529-539 https://doi.org/10.1016/j.chest.2023.09.020 Background Trajectories of bedside vital signs have been used to identify sepsis subphenotypes with distinct outcomes and treatment responses. The objective of this study was to validate the vitals trajector...

Critical Care: Original Research Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity Shailesh Bihari, Ubbo F. Wiersema Chest 2024; 165: 583-589 https://doi.org/10.1016/j.chest.2023.09.032 Background Studies investigating the effect of trunk inclination on respiratory mechanics in mechanically ventilated patients with ARDS have reported postural differences in partition respiratory ...

ORIGINAL ARTICLE Recombinant ADAMTS13 in Congenital Thrombotic Thrombocytopenic Purpura Authors: Marie Scully, Ana Antun, Spero R. Cataland, et al N Engl J Med 2024;390:1584-1596 DOI: 10.1056/NEJMoa2314793 Abstract BACKGROUND Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived products) administered as routine pr...

Critical Care: Original Research Prospective Evaluation of Venous Excess Ultrasound for Estimation of Venous Congestion August Longino, Katie Martin, Katarina Leyba, et al Chest 2024; 165: 590-600 https://doi.org/10.1016/j.chest.2023.09.029 Background Venous excess ultrasound (VExUS) is a novel ultrasound technique previously reported as a noninvasive measure of venous congestion and predictor of cardiorenal acute kidney injury. ...

Chest Infections: Original Research Prevalence, Risk Factors, Clinical Features, and Outcome of Influenza-Associated Pulmonary Aspergillosis in Critically Ill Patients: A Systematic Review and Meta-Analysis Lawrence Y. Lu, Hui Min Lee, Andrew Burke, et al Chest 2024; 165: 540-558 https://doi.org/10.1016/j.chest.2023.09.019 Background Influenza-associated pulmonary aspergillosis (IAPA) increasingly is being reported in critically ill patients. We conducte...

Chest Infections: Original Research Legionnaires Disease in Solid Organ Transplant Recipients: A Decade-Long Nationwide Study in France Guillaume Thizy, Adrien Flahault, Anne Scemla, et al Chest 2024; 165: 507-520 https://doi.org/10.1016/j.chest.2023.09.033 Background Legionnaires disease (LD) is a rare, life-threatening opportunistic bacterial infection that poses a significant risk to patients with impaired cell-mediated immunity such as solid organ tr...

Original Investigation  Nephrology March 8, 2024 Recovery Dynamics and Prognosis After Dialysis for Acute Kidney Injury Heng-Chih Pan, Hsing-Yu Chen, Nai-Chi Teng, et al JAMA Netw Open. 2024;7(3):e240351. doi:10.1001/jamanetworkopen.2024.0351 Key Points Question  Are baseline kidney function, acute kidney disease (AKD) severity, and post-AKD kidney function associated with adverse outcomes in...

ARTICLES| VOLUME 5, ISSUE 3, E235-E246, MARCH 2024 SARS-CoV-2 shedding and evolution in patients who were immunocompromised during the omicron period: a multicentre, prospective analysis Zoe Raglow, Diya Surie, James D Chappell, et al Lancet Microbe 2024; 5: E235-E246 Published: January 26, 2024 DOI: https://doi.org/10.1016/S2666-5247(23)00336-1 Summary Background Prolonged SARS-CoV-2 infections in people who are immunocompromised might predict or sou...

ARTICLES| VOLUME 5, ISSUE 3, E247-E260, MARCH 2024Download Full Issue Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study Simon Feys, Sam Vanmassenhove, Sirima Kraisin, et al Lancet Microbe 2024; 5: E247-E260 Published:January 24, 2024 DOI: https://doi.org/10.1016/S2666-5247(23)00368-3 Summary Background COVID-...