Original Investigation  January 31, 2024 Timing to First Whole Blood Transfusion and Survival Following Severe Hemorrhage in Trauma Patients Crisanto M. Torres, Kelly M. Kenzik, Noelle N. Saillant, et al JAMA Surg. Published online January 31, 2024. doi:10.1001/jamasurg.2023.7178 Key Points Question  Is the timing of first whole blood transfusion associated with improved early and late survival among adult trauma patients present...

ARTICLES|ONLINE FIRST A synbiotic preparation (SIM01) for post-acute COVID-19 syndrome in Hong Kong (RECOVERY): a randomised, double-blind, placebo-controlled trial Raphaela I Lau, Qi Su, Ivan S F Lau, et al Lancet Infect Dis Published: December 07, 2023 DOI: https://doi.org/10.1016/S1473-3099(23)00685-0 Summary Background Post-acute COVID-19 syndrome (PACS) affects over 65 million individuals worldwide but treatment options are scarce. We aimed to as...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 165, ISSUE 1, P110-127, JANUARY 2024 Effect of Admission and Onset Time on the Prognosis of Patients With Cardiogenic Shock Michael Behnes, Jonas Rusnak, Sascha Egner-Walter, et al Chest 2024; 163: 110-127 Published: August 11, 2023 DOI:https://doi.org/10.1016/j.chest.2023.08.011 Background The spectrum of patients with cardiogenic shock (CS) has changed significantly over time. CS has become especially more common i...

ARTICLES|ONLINE FIRST Long-term outcomes following hospital admission for COVID-19 versus seasonal influenza: a cohort study Yan Xie, Taeyoung Choi, Ziyad Al-Aly  Lancet Infect Dis Published: December 14, 2023 DOI:https://doi.org/10.1016/S1473-3099(23)00684-9 Summary Background Previous comparative analyses of people admitted to hospital for COVID-19 versus influenza evaluated the risk of death, hospital readmission, and a narrow set of health outcome...

ARTICLES|ONLINE FIRST Clarithromycin for early anti-inflammatory responses in community-acquired pneumonia in Greece (ACCESS): a randomised, double-blind, placebo-controlled trial Evangelos J Giamarellos-Bourboulis, Athanasios Siampanos, Amalia Bolanou, et al Lancet Respir Med Published: January 03, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00412-5 Summary Background Addition of macrolide antibiotics to β-lactam antibiotics for the treatment of ...

Perspective Secondary Cancers after Chimeric Antigen Receptor T-Cell Therapy Nicole Verdun, Peter Marks N Engl J Med January 24, 2024DOI: 10.1056/NEJMp2400209 Since the first such product was approved in 2017, chimeric antigen receptor (CAR) T-cell therapies have become important treatments for relapsed or refractory hematologic cancers, and the six products involving autologous CAR T cells that have been approved in the United States now cover a range of ind...

ARTICLES|ONLINE FIRST Efficacy and safety of an early oral switch in low-risk Staphylococcus aureus bloodstream infection (SABATO): an international, open-label, parallel-group, randomised, controlled, non-inferiority trial Achim J Kaasch, Luis Eduardo López-Cortés, Jesús Rodríguez-Baño, et al Lancet Infect Dis Published: January 17, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00756-9 Summary Background Staphylococcus aureus bloodst...

ARTICLES|ONLINE FIRST Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis Published: January 09, 2024 DOI: https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spectrum to narrow-spe...

ARTICLES|ONLINE FIRST Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial Yin Mo, Suchart Booraphun, Andrew Yunkai Li, et al Lancet Respir Med Published: January 22, 2024 DOI: https://doi.org/10.1016/S2213-2600(23)00418-6 Summary Background Ventilator-associated pneumonia (VAP) is associated with ...

ICU Management & Practice, Volume 23 - Issue 4, 2023 Seven Myths of Mechanical Ventilation in Paediatric and Neonatal Patients In this article, we will examine clinical concepts that have persisted over time, despite advancements in our understanding of physiology and technological innovations that have demonstrated their inapplicability in the routine clinical care of paediatric patients requiring respiratory support. These enduring beliefs have effectivel...