Research Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial Gordon McGregor, Harbinder Sandhu, Julie Bruce, et al BMJ 2024; 384 doi: https://doi.org/10.1136/bmj-2023-076506 (Published 07 February 2024)Cite this as: BMJ 2024;384:e076506 Abstract Objective To evaluate whether a structured online supervised ...

Original Investigation  January 17, 2023 Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart Failure: The TRANSFORM-HF Randomized Clinical Trial Robert J. Mentz, Kevin J. Anstrom, Eric L. Eisenstein, et al JAMA. 2023;329(3):214-223. doi:10.1001/jama.2022.23924 Key Points Question  Does torsemide reduce all-cause mortality compared with furosemide in patients with heart fail...

Original Investigation  February 8, 2024 Methylprednisolone as Adjunct to Endovascular Thrombectomy for Large-Vessel Occlusion Stroke: The MARVEL Randomized Clinical Trial MARVEL Trial Authors for the MARVEL Investigators JAMA. Published online February 8, 2024. doi:10.1001/jama.2024.0626 Key Points Question  Among patients with large-vessel occlusion acute ischemic stroke, does adjunctive intravenous methylprednisolone added to ...

Original Investigation  February 7, 2024 Health Insurance Status and Unplanned Surgery for Access-Sensitive Surgical Conditions Shukri H. A. Dualeh, Sara L. Schaefer, Nicholas Kunnath, et al JAMA Surg. Published online February 7, 2024. doi:10.1001/jamasurg.2023.7530 Key Points Question  What is the association between health insurance status and rates and outcomes of unplanned surgery for ac...

ARTICLES|ONLINE FIRST Hydrocortisone plus fludrocortisone for community acquired pneumonia-related septic shock: a subgroup analysis of the APROCCHSS phase 3 randomised trial Nicholas Heming, Alain Renault, Emmanuelle Kuperminc, et al Lancet Respir Med Published:February 01, 2024 DOI:https://doi.org/10.1016/S2213-2600(23)00430-7 Summary Background Glucocorticoids probably improve outcomes in patients hospitalised for community acquired pneumonia (CAP)...

Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis Lu Xia,  Viriya Hantrakun,  Prapit Teparrukkul, et al Am J Respir Crit Care Med 2024; 209: 288-298 DOI: 10.1164/rccm.202207-1349OC Abstract Rationale: The global burden of sepsis is greatest in low-resource settings. Melioidosis, infection with the gram-negative bacterium Burkholderia pseudomallei, is a frequent cause of fatal sepsis in en...

Original Investigation  February 6, 2024 Neonatal Outcomes After COVID-19 Vaccination in Pregnancy Mikael Norman, Maria C. Magnus, Jonas Söderling, et al JAMA. 2024;331(5):396-407. doi:10.1001/jama.2023.26945 Key Points Question  Does exposure to mRNA COVID-19 vaccination during pregnancy increase the risk of adverse events in newborn infants? Findings  In this population-based cohort study from Sweden and Norway tha...

Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Individualized Treatment Effects of Oxygen Targets in Mechanically Ventilated Critically Ill Adults Kevin G. Buell, Alexandra B. Spicer, Jonathan D. Casey, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2933 Key Points Question  Among critically ill adults, do the effects of peripheral oxygen-saturation (Spo2) targets on outcomes d...

Original Investigation  Caring for the Critically Ill Patient March 19, 2024 Lower vs Higher Oxygenation Target and Days Alive Without Life Support in COVID-19: The HOT-COVID Randomized Clinical Trial Frederik M. Nielsen, Thomas L. Klitgaard, Martin Siegemund, et al JAMA. Published online March 19, 2024. doi:10.1001/jama.2024.2934 Key Points Question  Does targeting a Pao2 of 60 mm Hg vs 90 mm Hg affect the number of days...

Original Investigation  Infectious Diseases January 2, 2024 Transition to Oral Antibiotic Therapy for Hospitalized Adults With Gram-Negative Bloodstream Infections Drew W. Engers, Pranita D. Tamma, Suiyini Fiawoo, et al JAMA Netw Open. 2024;7(1):e2349864. doi:10.1001/jamanetworkopen.2023.49864 Key Points Question  What is the timeline of transition from intravenous (IV) to oral antibiotics among patients with gram-negative blo...