ARTICLES| VOLUME 24, ISSUE 4, P375-385, APRIL 2024 Efficacy and safety of a structured de-escalation from antipseudomonal β-lactams in bloodstream infections due to Enterobacterales (SIMPLIFY): an open-label, multicentre, randomised trial Luis Eduardo López-Cortés, Mercedes Delgado-Valverde, Elisa Moreno-Mellado, et al Lancet Infect Dis 2024; 24: 375-385 DOI:https://doi.org/10.1016/S1473-3099(23)00686-2 Summary Background De-escalation from broad-spec...

Research Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study Björn Pasternak, Viktor Wintzell, Anders Hviid, et al BMJ 2024; 385 doi: https://doi.org/10.1136/bmj-2023-078225 (Published 10 April 2024)Cite this as: BMJ 2024;385:e078225 Abstract Objective To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer. Design Scandinav...

ORIGINAL ARTICLE Intensive Ambulance-Delivered Blood-Pressure Reduction in Hyperacute Stroke Gang Li, Yapeng Lin, Jie Yang, et al N Engl J Med 2024;390:1862-1872 DOI: 10.1056/NEJMoa2314741 Abstract BACKGROUND Treatment of acute stroke, before a distinction can be made between ischemic and hemorrhagic types, is challenging. Whether very early blood-pressure control in the ambulance improves outcomes among patients with undifferentiated acute stroke is ...

Original Investigation  Emergency Medicine April 9, 2024 Emergency Nurses’ Reasons for Not Recommending Their Hospital to Clinicians as a Good Place to Work K. Jane Muir, Raina M. Merchant, Karen B. Lasater, et al JAMA Netw Open. 2024;7(4):e244087. doi:10.1001/jamanetworkopen.2024.4087 Key Points Question  Why do emergency nurses not recommend their hospital to clinicians as a good place to work? Findings  This qu...

Original Investigation  April 10, 2024 Automated CT Analysis of Body Composition as a Frailty Biomarker in Abdominal Surgery Ijeamaka Anyene Fumagalli, Sidney T. Le, Peter D. Peng, et al JAMA Surg. Published online April 10, 2024. doi:10.1001/jamasurg.2024.0628 Key Points Question  Can preoperative computed tomography (CT) scans provide patient frailty assessments that are associated with outcomes of abdominal surgery? Finding...

Research Letter  April 8, 2024 Cardiac Function Before Sepsis and Clinical Outcomes Stuthi Iyer, Jason N. Kennedy, Jacob C. Jentzer, et al JAMA. Published online April 8, 2024. doi:10.1001/jama.2024.3917 Between 2009 and 2014, 21% of US adults with sepsis did not survive.1 Guidelines recommend urgent resuscitation of patients with sepsis, although the ideal treatment regimen is not clear2 and challenges to resuscitation, including t...

Research Letter  April 10, 2024 Intravascular Microaxial Left Ventricular Assist Device Manufacturer Payments to Cardiologists and Use of Devices Sanket S. Dhruva, Joseph S. Ross, Michael A. Steinman, et al JAMA. Published online April 10, 2024. doi:10.1001/jama.2024.4682 Mechanical circulatory support devices are increasingly used by physicians for patients receiving percutaneous coronary intervention (PCI).1 Use of intra-aortic balloon...

ORIGINAL ARTICLE Trial of Early Minimally Invasive Removal of Intracerebral Hemorrhage Gustavo Pradilla, Jonathan J. Ratcliff, Alex J. Hall, et al N Engl J Med 2024;390:1277-1289 DOI: 10.1056/NEJMoa2308440 Abstract BACKGROUND Trials of surgical evacuation of supratentorial intracerebral hemorrhages have generally shown no functional benefit. Whether early minimally invasive surgical removal would result in better outcomes than medical management is no...

ORIGINAL ARTICLE Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock Jacob E. Møller, Thomas Engstrøm, Lisette O. Jensen, et al N Engl J Med Published April 7, 2024 DOI: 10.1056/NEJMoa2312572 Abstract BACKGROUND The effects of temporary mechanical circulatory support with a microaxial flow pump on mortality among patients with ST-segment elevation myocardial infarction (STEMI) complicated by ca...

ORIGINAL ARTICLE Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy Martin S. Maron, Ahmad Masri, Michael E. Nassif, et al N Engl J Med 2024;390:1849-1861 DOI: 10.1056/NEJMoa2401424 Abstract BACKGROUND One of the major determinants of exercise intolerance and limiting symptoms among patients with obstructive hypertrophic cardiomyopathy (HCM) is an elevated intracardiac pressure resulting from left ventricular outflow tract obstruction. ...