ORIGINAL ARTICLE Phase 2 Trial of Anti-TL1A Monoclonal Antibody Tulisokibart for Ulcerative Colitis Bruce E. Sands, Brian G. Feagan, Laurent Peyrin-Biroulet, et al N Engl J Med 2024;391:1119-1129 DOI: 10.1056/NEJMoa2314076 Abstract BACKGROUND Tulisokibart is a tumor necrosis factor–like cytokine 1A (TL1A) monoclonal antibody in development for the treatment of moderately to severely active ulcerative colitis. A genetic-based diagnostic test was design...

ORIGINAL ARTICLE Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B Adam Cuker, Kaan Kavakli, Laurent Frenzel, et al N Engl J Med 2024;391:1108-1118 DOI: 10.1056/NEJMoa2302982 Abstract BACKGROUND Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1–2a study...

ORIGINAL ARTICLE Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection Shunying Zhao, Yunxiao Shang, Yong Yin, et al N Engl J Med 2024;391:1096-1107 DOI: 10.1056/NEJMoa2313551 Abstract BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of severe illness in infants, with no effective treatment. Results of a phase 2 trial suggested that ziresovir may have efficacy in the treatment of infants hospitalized with RSV infe...

Original Investigation  Surgery September 20, 2024 Costs of Transfer From Nontrauma to Trauma Centers Among Patients With Minor Injuries Bourke W. Tillmann, Avery B. Nathens, Matthew P. Guttman, et al JAMA Netw Open. 2024;7(9):e2434172. doi:10.1001/jamanetworkopen.2024.34172 Key Points Question  What are the health care costs associated with the transfer of patients with minor injuries from n...

ORIGINAL ARTICLE Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia Magnus Ekström, Anders Andersson, Savvas Papadopoulos, et al N Engl J Med 2024;391:977-988 Abstract BACKGROUND Long-term oxygen supplementation for at least 15 hours per day prolongs survival among patients with severe hypoxemia. On the basis of a nonrandomized comparison, long-term oxygen therapy has been recommended to be used for 24 hours per day, a more burdensom...

Original Investigation  September 16, 2024 Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial Zujin Luo, Yichong Li, Wenjun Li, et al JAMA. Published online September 16, 2024. doi:10.1001/jama.2024.15815 Key Points Q...

Effect of laughter exercise versus 0.1% sodium hyaluronic acid on ocular surface discomfort in dry eye disease: non-inferiority randomised controlled trial Jing Li, Yinglin Liao, Shi-Yao Zhang, et al BMJ 2024; 386 doi: https://doi.org/10.1136/bmj-2024-080474 (Published 11 September 2024)Cite this as: BMJ 2024;386:e080474 Abstract Objective To assess efficacy and safety of laughter exercise in patients with symptomatic dry eye disease. Design Non-i...

Original Investigation  August 30, 2024 Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial Matthieu Legrand, Jérémy Falcone, Bernard Cholley, et al JAMA. Published online August 30, 2024. doi:10.1001/jama.2024.17123 Key Points Question  Is a continuation strategy of renin-angiotensin system inhibitors ...

Original Investigation  Critical Care Medicine September 9, 2024 Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units Dana Mueller, David K. Bailly, Mousumi Banerjee, et al JAMA Netw Open. 2024;7(9):e2432393. doi:10.1001/jamanetworkopen.2024.32393 Key Points Question  Can 17 hospitals maintain the reduced in-hospital cardiac arrest (IHCA) rate they achi...

Original Investigation  Critical Care Medicine September 11, 2024 Iloprost and Organ Dysfunction in Adults With Septic Shock and Endotheliopathy: A Randomized Clinical Trial Morten H. Bestle, Jakob Stensballe, Theis Lange, et al JAMA Netw Open. 2024;7(9):e2432444. doi:10.1001/jamanetworkopen.2024.32444 Key Points Question  What is the effect of administration of iloprost vs placebo on the sev...