Original Investigation  Caring for the Critically Ill Patient Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients: The UK-ROX Randomized Clinical Trial Daniel S. Martin, Doug W. Gould, Tasnin Shahid, et al JAMA Published Online: June 12, 2025 doi: 10.1001/jama.2025.9663 Key Points Question  Does reducing exposure to supplemental oxygen by using a reduced peripheral oxygen saturation (Spo2) target of 90% ...

Editorial  April 10, 2025 Electronic Stewardship Prompts—Exploring the Why Behind the What Shinya Hasegawa, Daniel J. Livorsi JAMA Netw Open. 2025;8(4):e2512634. doi:10.1001/jamanetworkopen.2025.12634 Increasing antibiotic resistance is an urgent public health threat, and antibiotic stewardship is an important strategy for mitigating this threat.1 Antibiotic stewardship programs strive to improve patient safety by opt...

Original Investigation  April 16, 2025 Operative vs Nonoperative Treatment of Acute Cholecystitis in Older Adults With Multimorbidity Rachael C. Acker, Sara P. Ginzberg, James Sharpe, et al JAMA Surg. Published online April 16, 2025. doi:10.1001/jamasurg.2025.0729 Key Points Question  Is operative or nonoperative treatment better for treating acute cholecystitis in older adults with multimorbidi...

Research Letter  Gastroenterology and Hepatology May 21, 2025 Acute Kidney Injury and Hepatorenal Syndrome Among Hospitalized Patients With Chronic Liver Disease Robert J. Wong, Jeyasankar Balasubramanian, Mary Panaccio, et al JAMA Netw Open. 2025;8(5):e2511816. doi:10.1001/jamanetworkopen.2025.11816 Introduction The prevalence of chronic liver disease (CLD) is increasing,1,2 with alcohol-related ...

Original Investigation  Less Is More April 10, 2025 Improving Empiric Antibiotic Selection for Patients Hospitalized With Skin and Soft Tissue Infection: The INSPIRE 3 Skin and Soft Tissue Randomized Clinical Trial Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Intern Med. Published online April 10, 2025. doi:10.1001/jamainternmed.2025.0887 Key Points Question  Can computerized pr...

Original Investigation  Pediatrics April 11, 2025 Epinephrine vs Norepinephrine as Initial Treatment in Children With Septic Shock Matthew A. Eisenberg, Nathan Georgette, Alexandra H. Baker, et al JAMA Netw Open. 2025;8(4):e254720. doi:10.1001/jamanetworkopen.2025.4720 Key Points Question  Is there an association between the first vasoactive agent administered and outcomes in children with se...

Research Letter  April 9, 2025 Concordance of 30-Day Mortality and In-Hospital Mortality or Hospice Discharge After Sepsis Hallie C. Prescott, Megan Heath, Namita Jayaprakash, et al JAMA. Published online April 9, 2025. doi:10.1001/jama.2025.2526 Sepsis contributes to 1.7 million adult hospitalizations and 350 000 deaths annually in the United States.1To encourage improvements in sepsis management and outcom...

Invited Commentary  Health Informatics April 7, 2025 Are All Cytokine Storms Born Equal? Andre C. Kalil, Anum Abbas, Sias J. Scherger JAMA Netw Open. 2025;8(4):e253466. doi:10.1001/jamanetworkopen.2025.3466 One of the most difficult medical challenges we have faced for decades is regarding the human host response to infectious and noninfectious insults. We are still lacking understanding on what constitutes adaptive and maladaptive host re...

Original Investigation  Health Informatics April 7, 2025 Cytokine Storms in COVID-19, Hemophagocytic Lymphohistiocytosis, and CAR-T Therapy James P. Long, Rishab Prakash, Paul Edelkamp Jr, et al JAMA Netw Open. 2025;8(4):e253455. doi:10.1001/jamanetworkopen.2025.3455 Key Points Question  How do clinical patterns and outcomes of cytokine storm (CS) vary among etiologies of cytokine releas...

Original Investigation  Critical Care Medicine April 8, 2025 Post–Intensive Care Syndrome and Caregiver Burden: A Post Hoc Analysis of a Randomized Clinical Trial Soojung Ahn, Marianna LaNoue, Han Su, et al JAMA Netw Open. 2025;8(4):e253443. doi:10.1001/jamanetworkopen.2025.3443 Key Points Question  What is the long-term association between patient post–intensive care syndrome (PICS) and care...