Research Letter  February 17, 2025 Heterogeneity of Primary Outcomes in Large Atherosclerotic Cardiovascular Disease Trials Published in Prominent Medical Journals Daniel Shepshelovich, Dafna Yahav, Danielle R. Rome, et al JAMA Intern Med. Published online February 17, 2025. doi:10.1001/jamainternmed.2024.7694 The extent of heterogeneity in end points reported by randomized clinical trials (RCTs) of atherosc...

Research Letter  Health Policy February 19, 2025 Health Care Staffing Shortages and Potential National Hospital Bed Shortage Richard K. Leuchter, Benjo A. Delarmente, Sitaram Vangala, et al JAMA Netw Open. 2025;8(2):e2460645. doi:10.1001/jamanetworkopen.2024.60645 Introduction Between August 2020 and April 2024, US hospitals were mandated to report weekly occupancy to the Department of Health and Human...

A Randomized Controlled Trial of Efficacy and Safety of Fecal Microbiota Transplant for Preventing Recurrent Clostridioides difficile Infection Dimitri M Drekonja, Aasma Shaukat, Yuan Huang, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 52–60, https://doi.org/10.1093/cid/ciae467 Abstract Background Clostridioides difficile infection (CDI) is the most common cause of healthcare–associated in...

Original Investigation  Critical Care Medicine February 10, 2025 Response to Inhaled Nitric Oxide and Mortality Among Very Preterm Neonates With Pulmonary Hypertension Michelle Baczynski, Dany Weisz, Laura Thomas, et al JAMA Netw Open. 2025;8(2):e2458843. doi:10.1001/jamanetworkopen.2024.58843 Key Points Question  Is there an association between inhaled nitric oxide (iNO) responsiveness and m...

Population Sepsis Incidence, Mortality, and Trends in Hong Kong Between 2009 and 2018 Using Clinical and Administrative Data  Lowell Ling, Jack Zhenhe Zhang, Lok Ching Chang,  et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 91–100, https://doi.org/10.1093/cid/ciad491 Abstract Background Sepsis surveillance using electronic health record (EHR)–based data may provide more accurate epidemiologic esti...

Epidemiology and Outcomes of Antibiotic De-escalation in Patients With Suspected Sepsis in US Hospitals Kai Qian Kam, Tom Chen, Sameer S Kadri, et al Clinical Infectious Diseases, Volume 80, Issue 1, 15 January 2025, Pages 108–117, https://doi.org/10.1093/cid/ciae591 Abstract Background Little is known about the frequency, hospital-level variation, predictors, and outcomes of antibiotic de-escalation in suspected sepsis. Methods We...

Original Investigation  Caring for the Critically Ill Patient December 10, 2024 Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial Tobias Arleth, Josefine Baekgaard, Volkert Siersma, et al JAMA. 2025;333(6):479-489. doi:10.1001/jama.2024.25786 Key Points Question  Does an early, 8-hour restrictive oxygen strategy compared with a liberal oxygen stra...

Original Investigation  February 10, 2025 Evaluation of a Clinical Decision Support System for Imaging Requests: A Cluster Randomized Clinical Trial Stijntje W. Dijk, Claudia Wollny, Joerg Barkhausen, et al JAMA. Published online February 10, 2025. doi:10.1001/jama.2024.27853 Key Points Question  How does a clinical decision support system (the European Society of Radiology iGuide) affect the ap...

Articles Normobaric hyperoxia combined with endovascular treatment for acute ischaemic stroke in China (OPENS-2 trial): a multicentre, randomised, single-blind, sham-controlled trial Weili Li, Jing Lan, Ming Wei, et al Lancet 2025; 405: 486-497 DOI: https://doi.org/10.1016/S0140-6736(24)02809-5 Summary Background Endovascular treatment improves the recanalisation rate for patients with acute ischaemic stroke; however, even with endovascular treatment,...

Extracorporeal Blood Purification Therapies in Sepsis In Sepsis Tue, 7 Jan 2025 Sepsis is a life-threatening condition caused by a dysregulated host response to infection, leading to organ dysfunction. Sepsis involves both pro-inflammatory and anti-inflammatory processes, which can occur early in the disease and explain the severe clinical outcomes such as septic shock and premature death. However, each patient follows a unique immune response trajecto...