Mycoplasma pneumoniae infection in adult inpatients during the 2023–24 outbreak in France (MYCADO): a national, retrospective, observational study Ariane Gavaud, Matthieu Holub, Antoine Asquier-Khati, et al Lancet Infect Dis Available online 19 February 2025 https://doi.org/10.1016/S1473-3099(24)00805-3 Summary Background An epidemic of Mycoplasma pneumoniae infection has been observed in France since September, 2023. We aimed to describe ...

Optimal Vasopressin Initiation in Septic Shock In Sepsis Tue, 18 Mar 2025 Sepsis is a common and potentially fatal condition, causing over 270,000 deaths annually in the U.S. Emergency treatment involves fluids and vasopressors, with norepinephrine as the first-line choice and vasopressin as a second-line option when blood pressure remains unresponsive. However, the timing of vasopressin use is unclear due to the dynamic nature of septic shock and limi...

Original Investigation  Infectious Diseases April 24, 2025 Dwell Time and Risk of Bloodstream Infection With Peripheral Intravenous Catheters Marie-Céline Zanella, Gaud Catho, Holly Jackson, et al JAMA Netw Open. 2025;8(4):e257202. doi:10.1001/jamanetworkopen.2025.7202 Key Points Question  What is the association of dwell time with the risk of bloodstream infections with peripheral intravenou...

Original Investigation  Emergency Medicine April 25, 2025 Health Care Resource Utilization for Patients With Suspected Myocardial Infarction: A Secondary Analysis of the RACE-IT Randomized Clinical Trial Joseph Miller, Bernard Cook, Satheesh Gunaga, et al JAMA Netw Open. 2025;8(4):e256930. doi:10.1001/jamanetworkopen.2025.6930 Key Points Question  Does implementing a 0-hour and 1-hour (hereaf...

Original Investigation  April 24, 2025 Modeling Reemergence of Vaccine-Eliminated Infectious Diseases Under Declining Vaccination in the US Mathew V. Kiang, Kate M. Bubar, Yvonne Maldonado, et al JAMA. Published online April 24, 2025. doi:10.1001/jama.2025.6495 Key Points Question  How will declining childhood vaccination rates affect the risk of outbreaks and reemergence of previously eliminate...

Causes of and risk factors for postpartum haemorrhage: a systematic review and meta-analysis Idnan Yunas, Md Asiful Islam, Kulandaipalayam N Sindhu, et al Lancet 2025; 405: 1468-1480 Summary Background An understanding of the causes of postpartum haemorrhage is needed to provide appropriate treatment and services. Knowledge of the risk factors for postpartum haemorrhage can help address modifiable risk factors. We did a systematic review and meta-analysis t...

Original Investigation  Ethics April 23, 2025 Incidence and Prevalence of Reported Euthanasia Cases in Belgium, 2002 to 2023 Jacques Wels, Natasia Hamarat JAMA Netw Open. 2025;8(4):e256841. doi:10.1001/jamanetworkopen.2025.6841 Key Points Question  What factors are associated with patterns in euthanasia incidence and prevalence in Belgium? Findings  In this cross-sectional analysis of all 33 58...

ORIGINAL ARTICLE Global Effect of Cardiovascular Risk Factors on Lifetime Estimates The Global Cardiovascular Risk Consortium N Engl J Med Published March 30, 2025 DOI: 10.1056/NEJMoa2415879 Abstract BACKGROUND Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. ...

ORIGINAL ARTICLE Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis Kathryn Maitland, San Maurice Ouattara, Hadiza Sainna, et al N Engl J Med Published June 13, 2025 DOI: 10.1056/NEJMoa2505752 Abstract BACKGROUND International recommendations advise against the use of intravenous rehydration therapy in children with severe acute malnutrition because of the concern about fluid overload, but evidence to support this concern is la...

ORIGINAL ARTICLE Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation Karen J. Bosma, Karen E.A. Burns, Claudio M. Martin, et al N Engl J Med Published June 13, 2025 DOI: 10.1056/NEJMoa2505708 Abstract BACKGROUND In critically ill patients, acceleration of liberation from mechanical ventilation is important in order to reduce the risk of complications and to improve long-term outcomes. Whether the use of proportional-a...