CRITICAL CARE: ORIGINAL RESEARCHVolume 168, Issue 1P106-118July 2025Open AccessDownload Full Issue Prolonged Mechanical Ventilation in Critically Ill Patients: Six-Month Mortality, Care Pathways, and Quality of Life Nicolas Paul, Elena Ribet Buse, Julius J. Grunow, et al Chest 2025; 168: 106-118 Abstract Background There is limited knowledge about long-term mortality, care pathways, and health-related quality of life (HrQoL) among patients in the IC...

Original Investigation  Psychiatry Caring for Grandchildren and Dementia Among Older Adults in China Zi Zhou, Xiaoling Hong JAMA Netw Open 2025;8;(7):e2519622. doi:10.1001/jamanetworkopen.2025.19622 Key Points Question  Is grandchild caregiving associated with dementia, and are technology access and loneliness mediators of such an association? Findings  In this cohort study of 10 058 older adults, nonintensive grandchild careg...

Original Investigation  Surgery Postoperative Delirium in Older Adults Undergoing Noncardiac Surgery Heather L. Lander, Andrew W. Dick, Karen E. Joynt Maddox, et al JAMA Netw Open 2025;8;(7):e2519467. doi:10.1001/jamanetworkopen.2025.19467 Key Points Question  What is the association of postoperative delirium with adverse outcomes, and how much variation exists in hospital rates of postoperative delirium? Findings  In this coh...

Research Letter  The Failure of Life Expectancy to Fully Rebound to Prepandemic Levels Hannes Schwandt, Janet Currie, Till von Wachter, et al JAMA Published Online: July 9, 2025 doi: 10.1001/jama.2025.10439 US life expectancy plummeted during the COVID-19 pandemic and increased in 2022-2023.1 Although estimates for 2024 have not been reported for the US, vital statistics through 2024 are available for California. This study examined how California...

ORIGINAL ARTICLE Global Effect of Cardiovascular Risk Factors on Lifetime Estimates The Global Cardiovascular Risk Consortium N Engl J Med 2025;393:125-138 DOI: 10.1056/NEJMoa2415879 Abstract BACKGROUND Five risk factors account for approximately 50% of the global burden of cardiovascular disease. How the presence or absence of classic risk factors affects lifetime estimates of cardiovascular disease and death from any cause remains unclear. 五项危...

JOURNAL ARTICLE Concordance of Noninvasive Plasma Cell-free DNA With Invasive Diagnostics for Diagnosis of Invasive Fungal Disease Anthony Lieu, Alex N Zimmet, Joseph Pozdol, et al Clin Infect Dis 2025; 80: 1095-1102 https://doi.org/10.1093/cid/ciaf021 Abstract Background Mold plasma cell-free DNA (cfDNA) polymerase chain reaction (PCR) is a promising noninvasive diagnostic modality for early diagnosis of invasive mold disease (IMD) in immun...

JOURNAL ARTICLE Association Between Delayed Broad-Spectrum Gram-negative Antibiotics and Clinical Outcomes: How Much Does Getting It Right With Empiric Antibiotics Matter? Jonathan D Baghdadi, Katherine E Goodman, Laurence S Magder, et al Clin Infect Dis 2025; 80: 949-958 https://doi.org/10.1093/cid/ciaf039 Abstract Background Clinicians often start unnecessarily broad-spectrum empiric gram-negative antibiotics out of the concern that delayi...

Research Letter  Randomized Experiment of Recruitment Letter Design to Maximize Clinical Trial Enrollment Niklas Dyrby Johansen, David Preiss, Marion Mafham, et al JAMA Published Online: June 25, 2025 doi: 10.1001/jama.2025.9170 Most new medical therapies only offer small to moderate benefits above high-level standard care and require increasingly large trials to demonstrate efficacy in light of generally de...

JOURNAL ARTICLE Performance of Diagnostic Algorithms in Patients With Invasive Pulmonary Aspergillosis Stefan Hatzl, Christina Geiger, Lisa Kriegl, et al Clin Infect Dis 2025: 80: 1080-1087 https://doi.org/10.1093/cid/ciae633 Abstract Background Invasive pulmonary aspergillosis (IPA), once limited to immunocompromised patients, is now a severe complication in critically ill ICU patients without classic risk factors. Due to the difficulty of ...

Original Investigation  AI in Medicine Complete AI-Enabled Echocardiography Interpretation With Multitask Deep Learning Gregory Holste, Evangelos K. Oikonomou, Márton Tokodi, et al JAMA Published Online: June 23, 2025 doi: 10.1001/jama.2025.8731 Key Points Question  Can artificial intelligence (AI) fully automate echocardiogram interpretation? Findings  This study reports the dev...