Original Investigation Nonregistration, Discontinuation, and Nonpublication of Randomized Trials: A Systematic Review Benjamin Speich, Ala Taji Heravi, Christof M. Schönenberger, et al JAMA Netw Open 2025;8;(9):e2524440. doi:10.1001/jamanetworkopen.2025.24440 Key Points Question  What percentage of randomized clinical trials (RCTs) are unregistered, prematurely discontinued, or unpublished? Findings  This systematic review assessing 3...

Articles Profile of central line-associated bloodstream infections in adult, paediatric, and neonatal intensive care units of hospitals participating in a health-care-associated infection surveillance network in India: a 7-year multicentric study Rasna Parveen, Arpan Kumar Thakur, Sharad Srivastav, et al Lancet Global Health 2025; 13: e1564-e1573 https://doi.org/10.1016/S2214-109X(25)00221-9 Summary Background Central line-associated bloodstream infec...

Articles Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Infect Dis Available online 28 August 2025 https://doi.org/10.1016/S1473-3099(25)00361-5 Summary Background Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVE...

Articles Incidence of health-care-associated infections in long-term care facilities in nine European countries: a 12-month, prospective, longitudinal cohort study Enrico Ricchizzi, Elena Sasdelli, Anna Caterina Leucci, et al Lancet Infect Dis Available online 16 June 2025 https://doi.org/10.1016/S1473-3099(25)00217-8 Summary Background The number of older people in need of long-term care is increasing, and health-care-associated infections (HAIs) are...

Articles Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jiroveciipneumonia (PIC): a multicentre, double-blind, randomised controlled trial Virginie Lemiale, Matthieu Resche-Rigon, Yoann Zerbib, et al Lancet Respir Med 2025; 13: 800-808 https://doi.org/10.1016/S2213-2600(25)00125-0 Summary Background Pneumocystis jirovecii pneumonia in HIV-negative immunocompromised patients has a hospital mortality rate of 30–5...

ORIGINAL ARTICLE High-Dose Influenza Vaccine to Reduce Hospitalizations Jacobo Pardo-Seco, Carmen Rodríguez-Tenreiro-Sánchez, Iago Giné-Vázquez, et al N Engl J Med Published August 30, 2025 DOI: 10.1056/NEJMoa2509834 Abstract BACKGROUND Superior protection against laboratory-confirmed influenza has been proved for high-dose inactivated influenza vaccine, as compared with the standard dose, among adults 65 years of age or older. However, data on the re...

ORIGINAL ARTICLE High-Dose Influenza Vaccine Effectiveness against Hospitalization in Older Adults Niklas Dyrby Johansen, Daniel Modin, Matthew M. Loiacono, et al N Engl J Med Published August 30, 2025 DOI: 10.1056/NEJMoa2509907 Abstract BACKGROUND High-dose inactivated influenza vaccine has been shown to provide protection against influenza that is superior to that with the standard dose. However, data from individually randomized trials on the effec...

ORIGINAL ARTICLE Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias Christian Jøns, Chaoqun Zheng, Ulrik C.G. Winsløw, et al N Engl J Med Published August 29, 2025 DOI: 10.1056/NEJMoa2509542 Abstract BACKGROUND Hypokalemia and even low-normal plasma potassium levels increase the risk of ventricular arrhythmias among patients with cardiovascular disease. An assessment of a strategy of actively increasing plasma potassiu...

Articles Epidemiological and demographic trends and projections in global health from 1970 to 2050: a descriptive analysis from the third Lancet Commission on Investing in Health, Global Health 2050 Angela Y Chang, Sarah Bolongaita SM, Bochen Cao, et al Lancet 2025; 406: 940-949 https://doi.org/10.1016/S0140-6736(25)00902-X Summary Background Systematic analyses of global health trends can provide an accurate narrative of progress and challenges. We a...

Original Investigation  Critical Care Medicine Peripheral Vasopressor Use in Early Sepsis-Induced Hypotension Elizabeth S. Munroe, Ivan N. Co, Ivor Douglas, et al JAMA Netw Open 2025;8;(8):e2529148. doi:10.1001/jamanetworkopen.2025.29148 Key Points Question  How are peripheral vasopressors used in early sepsis resuscitation, and is their use safe? Findings  In this cohort study of 582 patients from the Crystalloid Liberal vs E...