Original Investigation  Critical Care Medicine Outcomes of Critically Ill Adult Patients With Acute Encephalitis Romain Sonneville, Camille Couffignal, Bertrand Souweine, et al JAMA Netw Open 2025;8;(9):e2532478. doi:10.1001/jamanetworkopen.2025.32478 Key Points Question  What are the long-term functional outcomes of adults with severe encephalitis, and how do recovery trajectories differ by cause of ence...

Research Letter  Initial Antibiotic Selection Strategy and Subsequent Antibiotic Use—Insights From the INSPIRE Trials Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA 2025;334;(12):1107-1109 doi:10.1001/jama.2025.11256 Four cluster-randomized trials have demonstrated that a stewardship bundle including real-time computerized provider order entry (CPOE) prompts safely reduced initial extended-spectrum antibiotic use by 17% to 35% among adult p...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT Editorial Key principles and recent developments for ventilatory management of the surgical critically ill patientDe Jong, A., Jaber, S. & Schaefer, M. LATEST ARTICLES Conference Reports and Expert Panel European Society of Intensive Care Medicine Clinical Practice Guideline on fluid therapy in adult critically ill patients: Part 3—fluid removal at de-escalation phaseOstermann, M....

Original Investigation  Critical Care Medicine Early Blood Pressure Targets in Acute Spinal Cord Injury: A Randomized Clinical Trial Ruba Sajdeya, N. David Yanez, Michael Kampp, et al JAMA Netw Open 2025;8;(9):e2525364. doi:10.1001/jamanetworkopen.2025.25364 Key Points Question  Compared with conventional blood pressure, does early blood pressure augmentation improve long-term neurologic outcomes in acute spinal cord injury? Findings&nb...

Articles Benchmarking progress in non-communicable diseases: a global analysis of cause-specific mortality from 2001 to 2019 NCD Countdown 2030 Collaborators Lancet 2025; 406: 1255-1282 https://doi.org/10.1016/S0140-6736(25)01388-1 Summary Background Non-communicable diseases (NCDs) have received substantial policy attention globally and in most countries. Our aim was to quantify how much NCD mortality changed from 2010 to 2019 in different countries,...

Original Investigation  Equity, Diversity, and Inclusion Accuracy of Artificial Intelligence vs Professionally Translated Discharge Instructions Melissa Martos, Blanca Fields, Samuel G. Finlayson, et al JAMA Netw Open 2025;8;(9):e2532312. doi:10.1001/jamanetworkopen.2025.32312 Key Points Question  How does the accuracy of artificial intelligence (AI)–based translation compare with professional translation of discharge instructions under ro...

JOURNAL ARTICLE EDITOR'S CHOICE Absence of Cerebrospinal Fluid Pleocytosis in Encephalitis Ralph Habis, Anna Kolchinski, Ashley N Heck, et al Clinical Infectious Diseases, Volume 81, Issue 1, 15 July 2025, Pages 179–187, https://doi.org/10.1093/cid/ciae391 Abstract Background Early diagnosis of encephalitis involves identifying signs of neuroinflammation, including cerebrospinal fluid (CSF) pleocytosis. However, an absence of CSF pleocytosis in ence...

Original Investigation  Postoperative Pulmonary Complications in Conventional Laparoscopic vs Robot-Assisted Abdominal Surgery Simon Corrado Serafini, Sabrine N. T. Hemmes, Verônica N. F. Queiroz, et al JAMA Surg Published Online: September 17, 2025 doi: 10.1001/jamasurg.2025.3581 Key Points Question  Is robotic-assisted surgery independently associated with higher incidence of postoperative pulmonary complications as compared with convent...

Evaluation of the impact of artificial intelligence-assisted image interpretation on the diagnostic performance of clinicians in identifying endotracheal tube position on plain chest X-ray: a multi-case multi-reader study  Alex Novak, Sarim Ather, Abdala T. Espinosa Morgado, et al Crit Care 2025; 29: 330 Abstract Background Incorrectly placed endotracheal tubes (ETTs) can lead to serious clinical harm. Studies have demonstrated the potential for artificial ...

Critical Care: Original Research Low-Intensity vs Moderate-Intensity Anticoagulation for Venovenous Extracorporeal Membrane Oxygenation: The Strategies for Anticoagulation During Venovenous Extracorporeal Membrane Oxygenation Pilot Trial Whitney D. Gannon, Elias H. Pratt, Melissa A. Vogelsong, et al Chest 2025; 168: 639-649 https://doi.org/10.1016/j.chest.2025.02.032 Background Bleeding is a common and sometimes fatal complicatio...