Early versus delayed catheter drainage for patients with necrotizing pancreatitis and early persistent organ failure (TIMING): a multicenter randomized controlled trial Ke, L., Li, G., Mao, W. et al. Intensive Care Med (2025). https://doi.org/10.1007/s00134-025-08020-x Abstract Purpose Acute necrotic collection (ANC) is an early, local complication of necrotizing pancreatitis, and guidelines recommend a deliberate delay in treating ANC. In patients with ear...

ONLINE FIRST (FREE ACCESS) STANDARD OF CARE IN THE INTENSIVE CARE UNIT OPEN ACCESS ~ What's New in Intensive Care Renal replacement therapyGaudry S., Srisawat N. & Joannidis M. LATEST ARTICLES Original Short- and long-term outcomes and 15-year time trends of kidney replacement therapy in critically ill patients with obesity: an observational cohortMonet C., Bouziane J., Pensier J., et al. Altered lower brainstem neurophysiological response is asso...

Original Investigation  Health Informatics Electronic Health Record Interventions to Reduce Risk of Hospital Readmissions: A Systematic Review and Meta-Analysis Badal S. B. Pattar, Abigail Ackroyd, Emir Sevinc, et al JAMA Netw Open 2025;8;(7):e2521785. doi:10.1001/jamanetworkopen.2025.21785 Key Points Question  Are electronic health record (EHR)–based interventions associated with reduced risk of hospital...

Research Letter  Initial Antibiotic Selection Strategy and Subsequent Antibiotic Use—Insights From the INSPIRE Trials Shruti K. Gohil, Edward Septimus, Ken Kleinman, et al JAMA Published Online: July 17, 2025 doi: 10.1001/jama.2025.11256 Four cluster-randomized trials have demonstrated that a stewardship bundle including real-time computerized provider order entry (CPOE) prompts safely reduced initial extend...

Critical Care: Research Letters Use of High-Dose Hydroxocobalamin for Septic Shock Jason R. Carr, Brian Locke, Jayshil J. Patel, et al Chest 2025; 168: 131-135 To the Editor: Septic shock, a global health burden with a case fatality rate exceeding 40%, is initiated and maintained by circulating nitric oxide and hydrogen sulfide that are emergent targets of therapeutic interest.1 High-dose (5-gm) hydroxocobalamin (vitamin B12) (HD-HOC) scavenges circula...

Original Investigation  Infectious Diseases Estimated Burden of Influenza and Direct and Indirect Benefits of Influenza Vaccination Mary G. Krauland, Alexis Mandell, Mark S. Roberts JAMA Netw Open 2025;8;(7):e2521324. doi:10.1001/jamanetworkopen.2025.21324 Key Points Question  What is the estimated influenza case burden, both direct and indirect, averted by vaccination? Findings  This decision ana...

Research Letter  Oncology “Me-Too” Drugs Compared With Original Drugs in Randomized Clinical Trials Timothée Olivier, Calvin Smith, Vinay Prasad, et al JAMA Intern Med Published Online: July 14, 2025 doi: 10.1001/jamainternmed.2025.2892 The development of “me-too” or “next-in-class” drugs in oncology may offer benefits including improved efficacy, better safety profiles, or economic competition.1,2 Addi...

Original Investigation  Public Health Body Mass Index in Children Before, During, and After the COVID-19 Pandemic Frederik Kirkemann Jensen, Sigrid Bjerge Gribsholt, Sara Schwartz, et al JAMA Netw Open 2025;8;(7):e2519528. doi:10.1001/jamanetworkopen.2025.19528 Key Points Question  Did prevalence of underweight, overweight, and obesity in schoolchildren change during and after the COVID-19 pandemic compared wi...

Research Global, regional, and national characteristics of the main causes of increased disease burden due to the covid-19 pandemic: time-series modelling analysis of global burden of disease study 2021 Can Chen, Wenkai Zhou, Yifan Cui, et al BMJ 2025; 390 doi: https://doi.org/10.1136/bmj-2024-083868 (Published 02 July 2025)Cite this as: BMJ 2025;390:e083868 Abstract Objective To quantify and identify the main caus...

CRITICAL CARE: ORIGINAL RESEARCHVolume 168, Issue 1P119-130July 2025 Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Anonymized, Randomized Controlled Trial Xiao Tang, Yan-Mei Gu, Yuan Shi, et al Chest 2025; 168: 119-130 Abstract Background The cuff leak test (CLT) is an important tool to assess the risk of upper airway obstruction after extubation. Research Questi...