ARTICLES| VOLUME 20, ISSUE 10, P1135-1140, OCTOBER 01, 2020 Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study Luca Carsana, Aurelio Sonzogni, Ahmed Nasr, et al Lancet Infect Dis 2020; 20: 1135-1140 Summary 摘要 Background 背景 COVID-19 is characterised by respiratory symptoms, which deteriorate into respiratory failure in a substantial proportion of cases, requiring intensive c...

Intensive Care Medicine ONLINE FIRST (FREE ACCESS)  Editorial - Arabi Y. et al. - The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19Original ~ Labeau S.O. et al. - Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs studyOriginal ~ Richards-Belle A. et al. - COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern IrelandLetter ...

Research Letter September 3, 2020 Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions Matthijs Kox, Nicole J. B. Waalders, Emma J. Kooistra, et al JAMA. 2020;324(15):1565-1567. doi:10.1001/jama.2020.17052 An abnormally strong proinflammatory response known as “cytokine storm” may play an important role in the pathophysiology of coronavirus disease 2019 (COVID-19), although cytokine storm remains ill defined.1 Sinha and colleagues...

Research Drug treatments for covid-19: living systematic review and network meta-analysis BMJ 2020; 370: m2980 doi: https://doi.org/10.1136/bmj.m2980 (Published 30 July 2020) Abstract Objective To compare the effects of treatments for coronavirus disease 2019 (covid-19). Design Living systematic review and network meta-analysis. Data sources US Centers for Disease Control and Prevention COVID-19 Research Articles Downloadable Database, which inc...

Research Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial BMJ 2020; 371 doi: https://doi.org/10.1136/bmj.m3485 (Published 07 October 2020)Cite this as: BMJ 2020;371:m3485 Abstract Objective To evaluate the effect of five years of supervised exercise training compared with recommendations for physical activity on mortality in older adults (70-77 years). Design Ra...

Original Investigation October 23, 2020 Effect of Regional Citrate Anticoagulation vs Systemic Heparin Anticoagulation During Continuous Kidney Replacement Therapy on Dialysis Filter Life Span and Mortality Among Critically Ill Patients With Acute Kidney Injury: A Randomized Clinical Trial Alexander Zarbock, Mira Küllmar, Detlef Kindgen-Milles, et al JAMA. 2020;324(16):1629-1639. doi:10.1001/jama.2020.18618 Abstract I...

Research Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial) Anup Agarwal, Aparna Mukherjee, Gunjan Kumar, et al BMJ 2020; 371:m3939 doi: https://doi.org/10.1136/bmj.m3939 Abstract Objective To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India. Design Open label, para...

ORIGINAL ARTICLE Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 John H. Stone, Matthew J. Frigault, Naomi J. Serling-Boyd, et al N Engl J Med October 21, 2020DOI: 10.1056/NEJMoa2028836 BACKGROUND The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. METHODS We performed a randomized, double-blind, placebo-controlled tria...

ARTICLES|ONLINE FIRST Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:October 05, 2020 DOI:https://doi.org/10.1016/S0140-6736(20)32013-4 Summary 摘要 Background 背景 Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies. Here, we repo...

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