ORIGINAL ARTICLE FREE PREVIEW Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury The STARRT-AKI Investigators for the Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group, the United Kingdom Critical Care Research Group, the Canadian Nephrology Trials Network, and the Irish Critical Care Trials Group N Engl J Med 2020; 383:240-251DOI: 10.1056/NEJMoa2000741 Abstract BACKGR...

ARTICLES|ONLINE FIRST Feasibility and physiological effects of prone positioning in non-intubated patients with acute respiratory failure due to COVID-19 (PRON-COVID): a prospective cohort study Anna Coppo, Giacomo Bellani, Dario Winterton, et al Lancet Respir Med Published:June 19, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30268-X Summary Background The COVID-19 pandemic is challenging advanced health systems, which are dealing with an overwhelming...

Hospitals’ Creative Responses to Coronavirus Challenges While hospitals around the world are struggling to fight the COVID-19 pandemic with limited or unavailable supplies and equipment, some are forced to become creative and find new ways to continue care delivery and, at the same time, protect the staff. One-Person Booths South Korea has already proven the effectiveness of its rigorous testing policies. Of over 8,500 confirmed cases only slightly above 1% ...

ORIGINAL ARTICLE Effect on Patient Safety of a Resident Physician Schedule without 24-Hour Shifts Christopher P. Landrigan, Shadab A. Rahman, Jason P. Sullivan, et al N Engl J Med 2020; 382:2514-2523DOI: 10.1056/NEJMoa1900669 Abstract BACKGROUND The effects on patient safety of eliminating extended-duration work shifts for resident physicians remain controversial. METHODS We conducted a multicenter, cluster-randomized, crossover trial comparing two...

ONLINE FIRST THIS WEEK(FREE ACCESS) Systematic Review ~ Duncan S. et al. - Interventions for oropharyngeal dysphagia in acute and critical care: a systematic review and meta-analysisOriginal ~ Uhel F. et al. - Mortality and host response aberrations associated with transient and persistent acute kidney injury in critically ill patients with sepsis: a prospective cohort studyOriginal ~ Awad A. et al. - Tim...

RECOVERY: World’s Largest COVID-19 Clinical Trial In the UK, the world’s largest clinical trial of potential coronavirus treatments, the Randomised Evaluation of COVID-19 Therapy trial (RECOVERY), is underway. It is aimed at assessing the effects of different treatments, including repurposed and novel drugs, on major outcomes in COVID-19.  You may also like: COVID-19 Will Revolutionise Imaging Practices The trial began on 19 March, and has been progress...

北京协和医院王春耀 ICU Management & Practice, Volume 20 - Issue 1, 2020 Personal Experience With Severe COVID-19 After 66 days in Wuhan COVID-2019 has become a worldwide pandemic. After working in Wuhan as intensive care physicians for 2 months, we have gained significant experience and would like to share our experience about daily care and supportive therapies for severe COVID-19 patients with our colleagues all over the world. The goal is for all of us to ...

ARTICLES|ONLINE FIRST Efficacy and safety of landiolol, an ultra-short-acting β1-selective antagonist, for treatment of sepsis-related tachyarrhythmia (J-Land 3S): a multicentre, open-label, randomised controlled trial Yasuyuki Kakihana, Osamu Nishida, Takumi Taniguchi, et al. Lancet Respir Med Published:March 31, 2020 DOI:https://doi.org/10.1016/S2213-2600(20)30037-0 Summary Background Tachycardia and atrial fibrillation frequently occur in patients bei...

Research Letter May 21, 2020 Postmortem Examination of Patients With COVID-19 Tina Schaller, Klaus Hirschbühl, Katrin Burkhardt, et al JAMA. 2020;323(24):2518-2520. doi:10.1001/jama.2020.8907 Approximately 15% of individuals affected by coronavirus disease 2019 (COVID-19) develop severe disease, and 5% to 6% are critically ill (respiratory failure and/or multiple organ dysfunction or failure).1,2 Severely ill and critically ill patients have a high mortal...

Mechanical Ventilation in COVID-19 There is no specific treatment for COVID-19 patients. For those who develop respiratory failure and are unable to oxygenate with non-invasive methods, critical care doctors are providing supportive therapy. Since the pandemic started, mechanical ventilation has routinely been employed to oxygenate seriously ill COVID-19 patients. Each hospital has developed its own criteria for identifying patients who require mechanical ven...