Original Investigation  April 26, 2023 Association of Trauma Molecular Endotypes With Differential Response to Transfusion Resuscitation Strategies Matthew R. Thau, Ted Liu, Neha A. Sathe, et al JAMA Surg. 2023;158(7):728-736. doi:10.1001/jamasurg.2023.0819 Key Points Question  Are trauma molecular endotypes associated with clinical outcomes and differential response to transfusion resuscitation strategies? Findings  In this s...

Original Investigation  May 24, 2023 Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial Maple Goh, Clare Hollewand, Stephen McBride, et al JAMA Surg. 2023;158(7):718-726. doi:10.1001/jamasurg.2023.1201 Key Points Question  What effect does incision-site injection of microdosed antibiotics have on the rate of surgical site infection (SSI) before skin can...

Original Investigation  August 7, 2023 Effects of Cuff Size on the Accuracy of Blood Pressure Readings: The Cuff(SZ) Randomized Crossover Trial Junichi Ishigami, Jeanne Charleston, Edgar R. Miller III, et al JAMA Intern Med. Published online August 7, 2023. doi:10.1001/jamainternmed.2023.3264 Key Points Question  What is the effect of using a regular size blood pressure (BP) cuff regardless of an individual’s mid-upper arm circum...

ARTICLES|ONLINE FIRST Dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA: a prospective cohort study Xianming Zhu, Kelly A Gebo, Alison G Abraham, et al Lancet Microbe Published:August 07, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00171-4 Summary Background Cytokines and chemokines play a critical role in the response to infection and vaccination. We aimed to assess the longitudinal association of COVID...

Research Association between antenatal corticosteroids and risk of serious infection in children Tsung-Chieh Yao, Sheng-Mao Chang, Chi-Shin Wu, et al BMJ 2023; 382 doi: https://doi.org/10.1136/bmj-2023-075835 (Published 02 August 2023)Cite this as: BMJ 2023;382:e075835 Abstract Objective To investigate the associations between exposure to antenatal corticosteroids and serious infection in children during the first three, six, and 12 months of life. ...

Repair of Acute Respiratory Distress Syndrome in COVID-19 by Stromal Cells (REALIST-COVID Trial): A Multicenter, Randomized, Controlled Clinical Trial Ellen A. Gorman,  Jennifer Rynne,  Hannah J. Gardiner, et al Am J Respir Crit Care Med 2023; 208: 256-269 Abstract Rationale: Mesenchymal stromal cells (MSCs) may modulate inflammation, promoting repair in coronavirus disease (COVID-19)–related acute respiratory distress syndrome (ARDS). Objectives: ...

A Pathology-based Case Series of Influenza- and COVID-19–associated Pulmonary Aspergillosis: The Proof Is in the Tissue Lore Vanderbeke,  Cato Jacobs,  Simon Feys, et al Am J Respir Crit Care Med 2023; 208: 301-311 Abstract Rationale: Invasive pulmonary aspergillosis has emerged as a frequent coinfection in severe coronavirus disease (COVID-19), similarly to influenza, yet the clinical invasiveness is more debated. Objectives: We investigated the ...

ARTICLES| VOLUME 5, ISSUE 8, E461-E473, AUGUST 2023Download Full Issue Antibody prevalence after three or more COVID-19 vaccine doses in individuals who are immunosuppressed in the UK: a cross-sectional study from MELODY Fiona A Pearce, Sean H Lim, Mary Bythell, et al Lancet Rheumatol 2023; 5: E461-E473 Published:August, 2023 DOI:https://doi.org/10.1016/S2665-9913(23)00160-1 Summary Background In the UK, additional COVID-19 vaccine booster...

ARTICLES| VOLUME 22, ISSUE 8, P685-711, AUGUST 2023Download Full Issue Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 GBD 2019 Meningitis Antimicrobial Resistance Collaborators Lancet Neurol 2023; 22: 685-711 Published:August, 2023 DOI:https://doi.org/10.1016/S1474-4422(23)00195-3 Summary Background Although meningitis is largely preventable, it still c...

ARTICLES| VOLUME 4, ISSUE 8, E632-E641, AUGUST 2023Download Full Issue Viral and antibody dynamics of acute infection with SARS-CoV-2 omicron variant (B.1.1.529): a prospective cohort study from Shenzhen, China Yang Yang, Liping Guo, Jing Yuan, et al Lancet Microbe 2023; 8: E632-E641 Published:July 14, 2023 DOI:https://doi.org/10.1016/S2666-5247(23)00139-8 Summary Background Elucidating viral dynamics within the host is important for desig...