ORIGINAL ARTICLE Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for Acute Pulmonary Embolism Kenneth Rosenfield, Frederikus A. Klok, Gregory Piazza, et al N Engl J Med Published March 28, 2026 DOI: 10.1056/NEJMoa2516567 Abstract BACKGROUND Whether anticoagulation alone is an adequate treatment for acute, intermediate-risk pulmonary embolism is uncertain. METHODS We conducted a multinational, adaptive-design trial with blinded outcome adj...

Original Investigation  Aging and Health Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks Joe B. B. Silva, Han-Chih T. Hsieh, Chanelle J. Howe, et al JAMA Intern Med Published Online: March 30, 2026 doi: 10.1001/jamainternmed.2026.0401 Key Points Question  Is initiation of antiviral chemoprophylaxis with oseltamivir for 70% or more of eligible nursing home (...

Original Investigation  Caring for the Critically Ill Patient High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial Christian Stoppe, Aileen Hill, Leopoldo C. Cancio, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10616 Key Points Question  Does high-dose intravenous vitamin C reduce a composite of 28-day mortality and persistent organ dysfunct...

ORIGINAL ARTICLE Discontinuation of Beta-Blocker Therapy after Myocardial Infarction Ki Hong Choi, Danbee Kang, Joon-Hyung Doh, et al N Engl J Med 2026;394:1302-1312 DOI: 10.1056/NEJMoa2601005 Abstract BACKGROUND The role of long-term beta-blocker therapy after a myocardial infarction in patients without left ventricular systolic dysfunction or heart failure is unclear in the era of contemporary coronary-artery reperfusion and secondary prevention int...

ONLINE FIRST (FREE ACCESS) PHYSIOLOGY IN CRITICAL ILLNESS What's New in Intensive Care Ventilator-induced lung injury: between tidal recruitment, overdistension, and the baby lung paradigmPlens, G.M., Costa, E.L.V. & Amato, M.B.P. How to interpret abnormal standard coagulation tests at the bedside in critically ill patients?Helms, J., Liu, L. & Russell, L. Understanding the Disease Immune responses and immunomodulation in sepsis: a call for ident...

Original Investigation  Caring for the Critically Ill Patient Integrated Telehealth Rehabilitation and Quality of Life in Mechanically Ventilated Adults: A Randomized Clinical Trial Regis Goulart Rosa, Rafael Barberena Moraes, Geraldine Trott, et al JAMA Published Online: June 10, 2026 doi: 10.1001/jama.2026.10617 Key Points Question  Among adults with acute hypoxemic respiratory failure requiring invasive mechanical ventilation, does a...

ORIGINAL ARTICLE Hospital Policy of Tranexamic Acid to Reduce Transfusion in Major Noncardiac Surgery Brett L. Houston, Daniel I. McIsaac, Rodney H. Breau, et al N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2515820 Abstract BACKGROUND Whether a hospital policy of tranexamic acid administration for patients undergoing major noncardiac surgery safely reduces the need for red-cell transfusion is uncertain. METHODS We conducted a multicen...

ORIGINAL ARTICLE Conservative Oxygen for Unresponsive Patients after Cardiac Arrest The LOGICAL Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group N Engl J Med Published June 10, 2026 DOI: 10.1056/NEJMoa2513814 Abstract BACKGROUND In patients who are unresponsive after resuscitation from cardiac arrest, limiting oxygen exposure to that necessary to achieve acceptable oxygenation may increase the likelihood of...

Research Accuracy of glomerular filtration rate estimation based on creatinine and cystatin C for monitoring moderate chronic kidney disease in adults: prospective, longitudinal cohort study Katie Scandrett, Alice J Sitch, Jonathan Barratt, et al BMJ 2026; 392 doi: https://doi.org/10.1136/bmj-2025-085005 (Published 19 March 2026)Cite this as: BMJ 2026;392:e085005 Abstract Objectives To provide evidence on the longitudinal accuracy of glomerular filtrat...

Original Investigation  Transesophageal Echocardiography During CPR in Patients With Out-of-Hospital Cardiac Arrest: The EXECT-CPR Randomized Clinical Trial Sheng-En Chu, Chiao-Yin Cheng, Chih-Jung Chang, et al JAMA Intern Med Published Online: March 23, 2026 doi: 10.1001/jamainternmed.2026.0102 Key Points Question  Does transesophageal echocardiography (TEE)–guided cardiopulmonary resuscitation...