Original Investigation  Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis Kevin Damman, Dirk J. van Veldhuisen, Johann Bauersachs, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7886 Key Points Question  What are the effects of digitalis glycoside treatment on cardiovascular death and worsening heart failure (HF) events in patients with HF with mildl...

Original Investigation  Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial Ganesan Karthikeyan, Niveditha Devasenapathy, Arpita Ghosh, et al JAMA Published Online: May 10, 2026 doi: 10.1001/jama.2026.7335 Key Points Question  Does digoxin, compared with placebo, reduce the composite of all-cause death or new-onset or worsening heart failure in symptomatic r...

CORRESPONDENCE Reducing Bacterial Contamination of Blood Bags with a Double Knot Kathleen Selleng, Halima Ismail, Christian Kohler, et al N Engl J Med 2026;394:1865-1866 DOI: 10.1056/NEJMc2600589 TO THE EDITOR: Bacterial contamination of blood for transfusions poses a serious risk to patients, particularly in resource-limited settings.1 Blood centers in high-income nations use heat-sealed tubing to close blood bags after donation; however, these too...

ORIGINAL ARTICLE Left Ventricular Unloading in High-Risk Percutaneous Coronary Intervention Divaka Perera, Matthew Ryan, Saad M. Ezad, et al N Engl J Med 2026;394:1779-1789 DOI: 10.1056/NEJMoa2515704 Abstract BACKGROUND Complex percutaneous coronary intervention (PCI) in patients with severely impaired left ventricular function carries a high risk of death and complications. Whether percutaneous left ventricular unlo...

Original Investigation  Caring for the Critically Ill Patient Prone Positioning in Infants With Acute Bronchiolitis: The PROPOSITIS Randomized Clinical Trial Florent Baudin, Robin Pouyau, Fabien Subtil, et al JAMA 2026;336;(4):315-322. doi:10.1001/jama.2026.11078 Key Points Question  Does prone positioning reduce escalation of respiratory support in infants aged 6 months or younger with moderate to severe bronchiolitis receiving high-flow ...

Original Investigation  Association of Rectal Cancer Accreditation with Patient Volume and Procedural Trends in the US Anthony Loria, Yusheng Jia, Ronald J. Weigel, et al JAMA Surg Published Online: May 6, 2026 doi: 10.1001/jamasurg.2026.1259 Key Points Question  Is National Accreditation Program for Rectal Cancer (NAPRC) accreditation associated with changes in rectal cancer patient volume, pro...

Research Letter  Physician Work Environment and Well-Being Turnover and Burnout Among Family Physicians Dhruv Khullar, Lawrence P. Casalino, Richard G. Kronick, et al JAMA Intern Med 2026;186;(5):635-637. doi:10.1001/jamainternmed.2026.0271 Physician burnout may be associated with leaving practice or moving to a new practice, resulting in clinician shortages, especially in primary care.1 Evidence suggests that pa...

Original Investigation  Red Blood Cell Exchange Transfusion for Severe Babesiosis STOP-BABESIOSIS Investigators JAMA Intern Med 2026;186;(5):597-607. doi:10.1001/jamainternmed.2026.0244 Key Points Question  Is red blood cell exchange transfusion (ET) associated with improved clinical outcomes in patients hospitalized with severe babesiosis? Findings  In this multicenter cohort study of 629 patients hospitalized with severe b...

Original Investigation  Changes in Nonprofit Hospitals’ Finances, Operations, and Quality of Care After Using Management Consultants Joseph Dov Bruch, Cal Chengqi Fang, Yan Bo Zeng, et al JAMA Published Online: May 4, 2026 doi: 10.1001/jama.2026.5027 Key Points Question  How much do nonprofit hospitals spend on management consultants, and following the initiation of a management consulting contr...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE OPEN ACCESS ~ Narrative Review Temperature control in acute brain injuryLavinio, A., Busl, K.M., Coles, J.P. et al. OBESITY IN THE ICU What's New in Intensive Care Gaps or paradoxes in clinical responses in obese patientsHernández, G., Muñiz Albaiceta, G. & Thille, A.W. LATEST ARTICLES Original Low versus standard calorie and protein feeding and renal dysfunction in ventilated adults w...