Original Investigation  MySurgeryRisk Model Predictions of Postoperative Complications and Mortality Yuanfang Ren, Esra Adiyeke, Ziyuan Guan, et al JAMA Surg 2026;161;(6):619-627. doi:10.1001/jamasurg.2026.1112 Key Points Question  Will applying the MySurgeryRisk framework, originally developed and prospectively validated on a single-center dataset, to a large multicenter dataset enhance generalizability wit...

Original Investigation  Early Enteral vs Oral Postoperative Nutrition After Pancreatoduodenectomy: The NUTRIWHI Randomized Clinical Trial Gaëtan-Romain Joliat, David Martin, Ismail Labgaa, et al JAMA Surg 2026;161;(6):575-582. doi:10.1001/jamasurg.2026.1048 Key Points Question  Does early supplemental enteral nutrition after pancreatoduodenectomy improve postoperative morbidity compared with oral nutrition? ...

Research Letter  Insufficient Sleep Among US Adolescents Across Behavioral Risk Groups Tanner J. Bommersbach, Mark Olfson, Taeho Greg Rhee JAMA 2026;335;(13):1173-1176. doi:10.1001/jama.2026.1417 Insufficient sleep among US adolescents is a major public health problem. Although studies documented recent declines in sleep duration across demographic groups,1 it is unknown whether sleep loss has disproportionately affected...

Original Investigation  Nutrition, Obesity, and Exercise Trends in Ultraprocessed Food Consumption Among Korean Children and Adolescents, 2007 to 2024 Sukyoung Jung, Eunice Hong Lim Lee, Jee Young Kim, et al JAMA Netw Open 2026;9;(4):e265528. doi:10.1001/jamanetworkopen.2026.5528 Key Points Question  What percentage of total energy intake among Korean youths came from ultraprocessed foods between 2007 and...

Original Investigation  An American College of Surgeons National Quality Improvement Collaborative to Enhance Lung Cancer Surgical Quality Kelley Chan, Eileen M. Reilly, Ryan C. Jacobs, et al JAMA Surg 2026;161;(6):609-617. doi:10.1001/jamasurg.2026.0902 Key Points Question  Can a national quality improvement (QI) collaborative model increase compliance for a lung cancer operative standard? Findings ...

Original Investigation  Critical Care Medicine High-Flow Nasal Oxygen Therapy After Cardiac Surgery: A Randomized Clinical Trial Edward Litton, Rachael L. Parke, Shay P. McGuinness, et al JAMA Netw Open 2026;9;(4):e265447. doi:10.1001/jamanetworkopen.2026.5447 Key Points Question  In patients at increased risk of pulmonary complications undergoing cardiac surgery, does prophylactic high-flow nasal oxygen ...

Research Letter  Geographic Shifts in Early-Stage Biopharmaceutical Innovation So-Yeon Kang, Yunan Ji JAMA Published Online: March 26, 2026 doi: 10.1001/jama.2026.1962 Biopharmaceutical innovation is increasingly viewed as a source of national economic and strategic advantage, prompting public investment in domestic drug research and development.1 At the same time, large pharmaceutical firms now perform a shrinking sh...

Original Investigation  Ethics Public Acceptance of Emergency Research Without Prior Consent in Stroke Masaru Suzuki, Mayumi Fukuda-Doi, Haruko Yamamoto, et al JAMA Netw Open 2026;9;(6):e2617347. doi:10.1001/jamanetworkopen.2026.17347 Key Points Question  Is emergency research without prospective consent (ERWPC) for hyperacute stroke acceptable to the public in Japan, where no established pathway exists? ...

Original Investigation  Pediatrics Acute Respiratory Tract Infections and Severe Disease Among Hospitalized Children Haifa Mtaweh, Caitlyn L. Kaziev, Carlee A. Feinstein, et al JAMA Netw Open 2026;9;(6):e2617575. doi:10.1001/jamanetworkopen.2026.17575 Key Points Question  What factors are associated with risk of severe disease among children hospitalized with acute respiratory infections? Findings ...

Articles Porcine kidney xenotransplantation as a bridge to allotransplantation: a first-in-human study Leonardo V Riella, Thiago J Borges, Ivy A Rosales, et al Lancet 2026; 408: 1029-1040 https://doi.org/10.1016/S0140-6736(26)01295-X Summary Background Kidney xenotransplantation offers a potential solution to the organ shortage, but questions remain regarding durability, zoonotic infection risk, and whether the immunological r...