Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial RECOVERY Collaborative Group Lancet Published:May 14, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00897-7 Summary Background Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to ho...

ARTICLES| VOLUME 397, ISSUE 10281, P1293-1300, APRIL 03, 2021 Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial Stéphane Gaudry, David Hajage, Laurent Martin-Lefevre, et al Lancet 2021; 397: 1293-1300 Summary Background Delaying renal replacement therapy (RRT) for some time in critically ill patients with severe acu...

Original Investigation May 6, 2021 Association Between Vaccination With BNT162b2 and Incidence of Symptomatic and Asymptomatic SARS-CoV-2 Infections Among Health Care Workers Yoel Angel, Avishay Spitzer, Oryan Henig, et al JAMA. Published online May 6, 2021. doi:10.1001/jama.2021.7152 Abstract Importance Randomized clinical trials have provided estimates of the effectiveness of the BNT162b2 vaccine against symptomatic SARS-CoV-2 infection,...

ARTICLES| VOLUME 397, ISSUE 10283, P1459-1469, APRIL 17, 2021 SARS-CoV-2 infection rates of antibody-positive compared with antibody-negative health-care workers in England: a large, multicentre, prospective cohort study (SIREN) Victoria Jane Hall, Sarah Foulkes, Andre Charlett, et al Lancet 2021; 379: 1459-1469 DOI:https://doi.org/10.1016/S0140-6736(21)00675-9 Summary Background Increased understanding of whether individuals who have r...

CORRESPONDENCE|ONLINE FIRST Thromboembolism and the Oxford–AstraZeneca COVID-19 vaccine: side-effect or coincidence? Søren Dinesen Østergaard, Morten Schmidt, Erzsébet Horváth-Puhó, et al Lancet Published: March 30, 2021 DOI:https://doi.org/10.1016/S0140-6736(21)00762-5 By mid March, 2021, vaccination against COVID-19 using the ChAdOx1 nCoV-19 (AZD1222) vaccine from Oxford–AstraZeneca1, 2was paused in a number of European countries due to reports of thrombo...

ORIGINAL ARTICLE A Microbiota-Directed Food Intervention for Undernourished Children Robert Y. Chen, Ishita Mostafa, Matthew C. Hibberd, et al N Engl J Med April 7, 2021DOI: 10.1056/NEJMoa2023294 BACKGROUND More than 30 million children worldwide have moderate acute malnutrition. Current treatments have limited effectiveness, and much remains unknown about the pathogenesis of this condition. Children with moderate acute malnutrition have perturbed developme...

ONLINE FIRST (FREE ACCESS)  Abraham P. et al. - Trauma patients do not benefit from a viscoelastic haemostatic assay-guided protocol, but why?MacDonald B. ~Fear and insight in the ICU bedChaudhuri D. et al. -  Corticosteroids in COVID-19 and non-COVID-19 ARDS: a systematic review and meta-analysisEvangelista I. et al. - Renal pyonephrosis with massive pleural empyema Cecconi M. et al. ~ Diversity and inclusivity...

ARTICLES| VOLUME 397, ISSUE 10285, P1637-1645, MAY 01, 2021 Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial RECOVERY Collaborative Group Lancet 2021; 397: 1637-1645 Summary Background In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods This ran...

ARTICLES| VOLUME 397, ISSUE 10280, P1204-1212, MARCH 27, 2021 Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study Christian Holm Hansen, Daniela Michlmayr, Sophie Madeleine Gubbels, et al. Lancet 2021; 397: 1204-1212 DOI:https://doi.org/10.1016/S0140-6736(21)00575-4 Summary Background 背景 The degree to which infection with SA...

Original Investigation Caring for the Critically Ill PatientMarch 25, 2021 Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial Domenico Luca Grieco, Luca S. Menga, Melania Cesarano, et al JAMA. Published online March 25, 2021. doi:10.1001/jama.2021.4682 Abstract Importance 背...