ORIGINAL ARTICLE Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant Jamie Lopez Bernal, Nick Andrews, Charlotte Gower, et al N Engl J Med 2021; 385:585-594DOI: 10.1056/NEJMoa2108891 Abstract BACKGROUND The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to a surge in cases in India and has now been detected acros...

ORIGINAL ARTICLE Physical Rehabilitation for Older Patients Hospitalized for Heart Failure Dalane W. Kitzman, David J. Whellan, Pamela Duncan, et al N Engl J Med 2021; 385:203-216DOI: 10.1056/NEJMoa2026141 Abstract BACKGROUND Older patients who are hospitalized for acute decompensated heart failure have high rates of physical frailty, poor quality of life, delayed recovery, and frequent rehospitalizations. Interventions to address physical frailty in thi...

Original Investigation Caring for the Critically Ill PatientAugust 31, 2021 Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial James J. McNamee, Michael A. Gillies, Nicholas A. Barrett, et al JAMA. Published online August 31, 2021. doi:10.1001/jama.2021.13374 Abstract...

Original Investigation Caring for the Critically Ill Patient Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial Harry Gelissen, Harm-Jan de Grooth, Yvo Smulders, et al JAMA. Published online August 31, 2021. doi:10.1001/jama.2021.13011 Abstract Importance  Hyperoxemia may increase organ dysfunction in critically ill patients, but optimal oxygenation targets are unkno...

Original Investigation August 3, 2021 Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial Bronagh Blackwood, Lyvonne N. Tume, Kevin P. Morris, et al JAMA. 2021;326(5):401-410. doi:10.1001/jama.2021.10296 Abstract Importance  There is limited evidence on the optimal strategy for liberating infants and childr...

ORIGINAL ARTICLE Covid-19 Breakthrough Infections in Vaccinated Health Care Workers Moriah Bergwerk, Tal Gonen, Yaniv Lustig, et al N Engl J Med July 28, 2021DOI: 10.1056/NEJMoa2109072 Abstract BACKGROUND Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed t...

Research Real time remote symptom monitoring during chemotherapy for cancer: European multicentre randomised controlled trial (eSMART) Roma Maguire, Lisa McCann, Grigorios Kotronoulas, et al BMJ 2021; 374 doi: https://doi.org/10.1136/bmj.n1647 (Published 22 July 2021) Cite this as: BMJ 2021;374:n1647 Abstract Objective To evaluate effects of remote monitoring of adjuvant chemotherapy related side effects via the Advanced Symptom Management System (A...

Original Investigation July 27, 2021 Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial Dimitri M. Drekonja, Barbara Trautner, Carla Amundson, et al JAMA. 2021;326(4):324-331. doi:10.1001/jama.2021.9899 Abstract Importance  Determination of optimal treatment durations for common infectious diseases is an important strategy to preserve an...

Original Investigation July 27, 2021 Effect of a Hospital and Postdischarge Quality Improvement Intervention on Clinical Outcomes and Quality of Care for Patients With Heart Failure With Reduced Ejection Fraction: The CONNECT-HF Randomized Clinical Trial Adam D. DeVore, Bradi B. Granger, Gregg C. Fonarow, et al JAMA. 2021;326(4):314-323. doi:10.1001/jama.2021.8844 Abstract Importance  Adoption of guideline-directed medical therapy for patient...

ICU Management & Practice, Volume 21 - Issue 2, 2021 Intensive Care Physiotherapists Should be Using Point of Care Ultrasound (POCUS) An overview of the potential of POCUS on clinical decision making at the bedside and the need to add it as a new diagnostic tool by intensive care physiotherapists. Introduction Intensive care physiotherapists often rely on standard assessment tools, such as measures of physiological function (arterial blood gases)...