Original Investigation Caring for the Critically Ill PatientDecember 8, 2021 Effect of Use of a Bougie vs Endotracheal Tube With Stylet on Successful Intubation on the First Attempt Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial Brian E. Driver, Matthew W. Semler, Wesley H. Self, et al JAMA. Published online December 8, 2021. doi:10.1001/jama.2021.22002 Abstract Importance  For critically i...

ORIGINAL ARTICLE Milvexian for the Prevention of Venous Thromboembolism Jeffrey I. Weitz, John Strony, Walter Ageno, et al N Engl J Med 2021; 385:2161-2172DOI: 10.1056/NEJMoa2113194 Abstract BACKGROUND Factor XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism may be more effective and result in less bleeding than conventional anticoagulants. Additional data are needed regarding the efficacy and safety of milvexian, an ...

ORIGINAL ARTICLE Protection against Covid-19 by BNT162b2 Booster across Age Groups Yinon M. Bar-On, Yair Goldberg, Micha Mandel, et al N Engl J Med 2021; 385:2421-2430DOI: 10.1056/NEJMoa2115926 Abstract BACKGROUND After promising initial results from the administration of a third (booster) dose of the BNT162b2 messenger RNA vaccine (Pfizer–BioNTech) to persons 60 years of age or older, the booster campaign in Israel was gradually expanded to persons in y...

ORIGINAL ARTICLE BNT162b2 Vaccine Booster and Mortality Due to Covid-19 Ronen Arbel, Ariel Hammerman, Ruslan Sergienko, et al N Engl J Med 2021; 385:2413-2420DOI: 10.1056/NEJMoa2115624 Abstract BACKGROUND The emergence of the B.1.617.2 (delta) variant of severe acute respiratory syndrome coronavirus 2 and the reduced effectiveness over time of the BNT162b2 vaccine (Pfizer–BioNTech) led to a resurgence of coronavirus disease 2019 (Covid-19) cases in popul...

Original Investigation November 30, 2021 Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt, et al JAMA. Published online November 30, 2021. doi:10.1001/jama.2021.20929 Abstract Importance  It is unclear whether administration of calcium has a beneficial effect ...

Feature Christmas 2021: What if . . . ? Anticipating the ageing trajectories of superheroes in the Marvel cinematic universe Sarah T Fox, Natasha Reid, Ida Tornvall, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-068001 (Published 13 December 2021)Cite this as: BMJ 2021;375:e068001 Ruth Hubbard and colleagues examine the personal traits and health behaviours of five of Marvel's superheroes and envisage the challenges this extraordinary cohort m...

ORIGINAL ARTICLE Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients Angélica Jayk Bernal, Monica M. Gomes da Silva, Dany B. Musungaie, et al N Engl J Med December 16, 2021DOI: 10.1056/NEJMoa2116044 Abstract BACKGROUND New treatments are needed to reduce the risk of progression of coronavirus disease 2019 (Covid-19). Molnupiravir is an oral, small-molecule antiviral prodrug that is active against severe acute respiratory syndrome coro...

CORRESPONDENCE Efficacy of Natural Immunity against SARS-CoV-2 Reinfection with the Beta Variant Hiam Chemaitelly, Roberto Bertollini, Laith J. Abu-Raddad N Engl J Med December 15, 2021DOI: 10.1056/NEJMc2110300 TO THE EDITOR: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) beta (B.1.351) variant of concern harbors mutations that can mediate immune evasion, and it appears to be less sensitive than the alpha (B.1.1.7) variant or wild-type vir...

Feature Christmas 2021: What a Wonderful World Just a smidge, or a bridge too far? Slang use in the ICU James M Hodgetts, Ayat Mohamed, Stephen Lewis BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067900 (Published 16 December 2021)Cite this as: BMJ 2021;375:e067900 A shared lingo can create cohesion in “the unit,” but James M Hodgetts and colleaguesask whether this is exclusionary and puts patient safety at risk Towards the end of the second...

Research Christmas 2021: What a Wonderful World Association of Logic’s hip hop song “1-800-273-8255” with Lifeline calls and suicides in the United States: interrupted time series analysis Thomas Niederkrotenthaler, Ulrich S Tran, Madelyn Gould, et al BMJ 2021; 375 doi: https://doi.org/10.1136/bmj-2021-067726 (Published 13 December 2021)Cite this as: BMJ 2021;375:e067726 Abstract Objective To assess changes in daily call volumes to the US National...