ORIGINAL ARTICLE Protection by a Fourth Dose of BNT162b2 against Omicron in Israel Yinon M. Bar-On, Yair Goldberg, Micha Mandel, et al N Engl J Med April 5, 2022DOI: 10.1056/NEJMoa2201570 Abstract BACKGROUND On January 2, 2022, Israel began administering a fourth dose of BNT162b2 vaccine to persons 60 years of age or older. Data are needed regarding the effect of the fourth dose on rates of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-...

ORIGINAL ARTICLE Intramuscular AZD7442 (Tixagevimab–Cilgavimab) for Prevention of Covid-19 Myron J. Levin, Andrew Ustianowski, Stéphane De Wit, et al N Engl J Med April 20, 2022DOI: 10.1056/NEJMoa2116620 Abstract BACKGROUND The monoclonal-antibody combination AZD7442 is composed of tixagevimab and cilgavimab, two neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that have an extended half-life and have been show...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 161, ISSUE 2, P392-406, FEBRUARY 01, 2022 Effects of Compliance With the Early Management Bundle (SEP-1) on Mortality Changes Among Medicare Beneficiaries With Sepsis: A Propensity Score Matched Cohort Study Sean R. Townsend, Gary S. Phillips, Reena Duseja, et al Chest 2022; 161: 392-406 Background US hospitals have reported compliance with the SEP-1 quality measure to Medicare since 2015. Finding an a...

ARTICLES|ONLINE FIRST The first WHO global survey on infection prevention and control in health-care facilities Sara Tomczyk, Anthony Twyman, Marlieke E A de Kraker, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00809-4 Summary Background WHO core components for infection prevention and control (IPC) are important building blocks for effective IPC programmes. To our knowledge, we did the first WHO globa...

ARTICLES|ONLINE FIRST High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial Rémi Coudroy, Jean-Pierre Frat, Stephan Ehrmann, et al Lancet Respir Med Published:March 21, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00096-0 Summary Background Although non-invasive ventilation (NIV) is recommended for immunocompromised patients...

ARTICLES|ONLINE FIRST Implementation of hand hygiene in health-care facilities: results from the WHO Hand Hygiene Self-Assessment Framework global survey 2019 Marlieke E A de Kraker, Ermira Tartari, Sara Tomczyk, et al Lancet Infect Dis Published: February 21, 2022 DOI:https://doi.org/10.1016/S1473-3099(21)00618-6 Summary Background Hand hygiene is at the core of effective infection prevention and control (IPC) programmes. 10 years after the developme...

Research Letter April 8, 2022 Systemic Corticosteroid Use for COVID-19 in US Outpatient Settings From April 2020 to August 2021 Marie C. Bradley, Silvia Perez-Vilar, Yoganand Chillarige, et al JAMA. Published online April 8, 2022. doi:10.1001/jama.2022.4877 In June 2020, preliminary results for the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial conducted in the UK indicated benefit from dexamethasone in severely ill hospitalized pati...

Original Investigation Caring for the Critically Ill PatientFebruary 18, 2022 Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge Elie Azoulay, Matthieu Resche-Rigon, Bruno Megarbane, et al JAMA. Published online February 18, 2022. doi:10.1001/jama.2022.2017 Key Points Question  Is the risk of posttraumatic stress disorder (PTSD) symptoms in...

ARTICLES|ONLINE FIRST Screening and vaccination against COVID-19 to minimise school closure: a modelling study Elisabetta Colosi, Giulia Bassignana, Diego Andrés Contreras, et al Lancet Infect Dis Published:April 01, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00138-4 Summary Background Schools were closed extensively in 2020–21 to counter SARS-CoV-2 spread, impacting students' education and wellbeing. With highly contagious variants expanding in E...

Original Investigation Caring for the Critically Ill PatientFebruary 22, 2022 Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial Jan Belohlavek, Jana Smalcova, Daniel Rob, et al JAMA. 2022;327(8):737-747. doi:10.1001/jama.2022.1025 Key Points Question  ...