Original Investigation  Caring for the Critically Ill Patient Effect of Automated Closed-Loop Ventilation vs Protocolized Conventional Ventilation on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial Jante S. Sinnige, Laura A. Buiteman-Kruizinga, Janneke Horn, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24384 Key Points Question  Among critically ill adults receiving invasive mechanical ...

Original Investigation  Caring for the Critically Ill Patient Precision Immunotherapy to Improve Sepsis Outcomes: The ImmunoSep Randomized Clinical Trial Evangelos J. Giamarellos-Bourboulis, Antigone Kotsaki, Ioanna Kotsamidi, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.24175 Key Points Question  Does immunotherapy tailored to the type of immune dysregulation improve outcomes among patients with sepsis? Findi...

ARTICLES Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 GBD 2023 Causes of Death Collaborators Lancet 2025; 406: 1811-1872 DOI: 10.1016/S0140-6736(25)01330-3 External Link Summary Background Comprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality...

Articles Duration of the serological response and effectiveness of the inactivated influenza vaccine in healthy adults aged 18–65 years: a systematic review and meta-analysis Joshua Nazareth, Neyme Veli, Daniel Pan, et al Lancet Microbe Available online 7 October 2025 https://doi.org/10.1016/j.lanmic.2025.101136 Summary Background The protection provided by the inactivated influenza vaccine (IIV) in adults can wane during a single influenza season. We ai...

Articles Influenza vaccination to improve outcomes for patients with acute heart failure (PANDA II): a multiregional, seasonal, hospital-based, cluster-randomised, controlled trial in China Craig S Anderson, Chang Hua, Zhiyan Wang, et al Lancet 2025; 406: 1020-1031 https://doi.org/10.1016/S0140-6736(25)01485-0 Summary Background Influenza vaccination is widely recommended to prevent death and serious illness in vulnerable people, including those with ...

ONLINE FIRST (FREE ACCESS) THE BRAIN IN THE LINE OF FIRE Editorial Neurotoxicity of sedative drugs: a matter of concern in adults?Landoni G., Kotani Y. & Lomivorotov V. Maintenance and resuscitation fluids for brain injury: keep them salty and not too sweet but mind the kidneyvan Regenmortel N., van der Jagt M. Transfusion targets after acute brain injury: the view of the trialistsTaccone, F. S., English, S. W. & Turgeon, A. F.  OPEN ACCESS ~ Wha...

Original Investigation  Pediatrics Antenatal Corticosteroids and Infectious Diseases Throughout Childhood Fabienne Decrue, Emily M. Frier, Chun Lin, et al JAMA Netw Open 2025;8;(10):e2536809. doi:10.1001/jamanetworkopen.2025.36809 Key Points Question  Is maternal antenatal corticosteroid treatment associated with increased susceptibility for respiratory and nonrespiratory infections in offspring from chil...

Research Letter  Public Health Mortality Trends Among Early Adults in Germany, 2011 to 2023 Christof Kuhbandner, Matthias Reitzner JAMA Netw Open 2025;8;(10):e2537349. doi:10.1001/jamanetworkopen.2025.37349 Introduction A recent study found that mortality among early adults (aged 25 to 44 years) in the US increased substantially since 2010, following a 2-phase pattern.1 The first phase, through 2019, was characterized by a steady rise in excess...

Original Investigation  Nutrition, Obesity, and Exercise Child Body Mass Index and Health Care Costs in England Olu Onyimadu, Alison Hayes, Patrick Fahr, et al JAMA Netw Open 2025;8;(10):e2537560. doi:10.1001/jamanetworkopen.2025.37560 Key Points Question  What is the health care cost burden attributable to unhealthy weight status among children in England? Findings  In this cross-sectional s...

Original Investigation  Obstetrics and Gynecology First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies Clément Bernard, Tom Duchemin, Lise Marty, et al JAMA Netw Open 2025;8;(10):e2538039. doi:10.1001/jamanetworkopen.2025.38039 Key Points Question  Are messenger RNA (mRNA)–based COVID-19 vaccines teratogenic ? Findings  In this nationwide cohort study of 527 564 live-born infants, 130 338 (24.7%) we...