Original Investigation  Rituximab for Relapsing Nephrotic Syndrome in Adults: A Randomized Clinical Trial Yoshitaka Isaka, Yusuke Sakaguchi, Maki Shinzawa, et al JAMA 2025;334;(22):2011-2019. doi:10.1001/jama.2025.19316 Key Points Question  Does rituximab, compared with placebo, prevent relapse in adult patients with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome? Findings&n...

Original Investigation  Gastroenterology and Hepatology Low-Molecular-Weight Heparin Plus Insulin in Hypertriglyceridemic Acute Pancreatitis: A Randomized Clinical Trial Wenhua He, Ling Ding, Zhijun Liu, et al JAMA Netw Open 2025;8;(11):e2542124. doi:10.1001/jamanetworkopen.2025.42124 Key Points Question  Is low-molecular-weight heparin combined with insulin superior to insulin alone in improving clinical...

Original Investigation  Prediction of Bacteremia and Bacterial Meningitis Among Febrile Infants Aged 28 Days or Younger Brett Burstein, Thomas Waterfield, Etimbuk Umana, et al JAMA Published Online: December 8, 2025 doi: 10.1001/jama.2025.21454 Key Points Question  How accurately does a clinical prediction rule based on urinalysis, procalcitonin, and absolute neutrophil count identify febrile yo...

Original Investigation  Caring for the Critically Ill Patient Intraoperative Driving Pressure–Guided High PEEP vs Standard Low PEEP for Postoperative Pulmonary Complications Writing and Steering Committees for the DESIGNATION–Investigators JAMA Published Online: December 3, 2025 doi: 10.1001/jama.2025.23373 Key Points Question  Do intraoperative driving pressure–guided high positive end-expiratory pressure (PEEP) and recr...

Original Investigation  Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial Renato D. Lopes, Edimar Alcides Bocchi, Luis Eduardo Echeverría, et al JAMA Published Online: December 3, 2025 doi: 10.1001/jama.2025.19808 Key Points Question  Are guideline-recommended treatments for heart failure (HF) effective and safe in pati...

Original Investigation  Surgery Surgical Low-Value Care Between Fee-For-Service and Salaried Health Care Systems Andrew J. Schoenfeld, Kaitlyn E. Holly, Madison N. Cirillo, et al JAMA Netw Open 2025;8;(12):e2546213. doi:10.1001/jamanetworkopen.2025.46213 Key Points Question  Is a health care system’s reimbursement model associated with provision of low-value surgical care? Findings  This coho...

Original Investigation  Infectious Diseases Seven-Day vs Four-Day Infusion Set Replacement Interval and Catheter-Related Infections Shalini Elangovan, Yiying Cai, Brett G. Mitchell, et al JAMA Netw Open 2025;8;(12):e2546398. doi:10.1001/jamanetworkopen.2025.46398 Key Points Question  Is adopting a 7-day infusion set replacement interval for catheter-related bloodstream infections cost-effective, without increasing infection risk, compared ...

Original Investigation  Critical Care Medicine Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients Feng Xie, Yifan Yao, Yue Ma, et al JAMA Netw Open 2025;8;(12):e2552771. doi:10.1001/jamanetworkopen.2025.52771 Key Points Question  Is daily intravenous pantoprazole cost-effective in preventing upper gastrointestinal bleeding in mechanically ventilated patients compared with no pa...

Original Investigation Caring for the Critically Ill Patient Levosimendan to Facilitate Weaning From ECMO in Patients With Severe Cardiogenic Shock: The LEVOECMO Randomized Clinical Trial Alain Combes, Ouriel Saura, Nicolas Nesseler, et al JAMA Published Online: December 1, 2025 doi: 10.1001/jama.2025.19843 Key Points Question  In patients with severe but potentially reversible cardiogenic shock w...

Original Investigation  Pharmacy and Clinical Pharmacology Trimethoprim-Sulfamethoxazole and Acute Respiratory Failure in Adolescents and Young Adults Fatemeh Ahmadi, Eric McArthur, Facundo Garcia-Bournissen, et al JAMA Netw Open 2025;8;(11):e2545251. doi:10.1001/jamanetworkopen.2025.45251 Key Points Question  Is the use of trimethoprim-sulfamethoxazole (TMP-SMX) associated with an increased 30-day risk of hospital visits for acute respira...