CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P346-355, AUGUST 01, 2022 Defibrotide Therapy for SARS-CoV-2 ARDS David Frame, Gianni B. Scappaticci, Thomas M. Braun, et al Chest 2022; 162: 346-355 Published:April 08, 2022 DOI:https://doi.org/10.1016/j.chest.2022.03.046 Background SARS-CoV-2-related ARDS is associated with endothelial dysfunction and profound dysregulation of the thrombotic-fibrinolytic pathway. Defibrotide is a pol...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P356-366, AUGUST 01, 2022 Targeted Temperature Management After In-Hospital Cardiac Arrest: An Ancillary Analysis of Targeted Temperature Management for Cardiac Arrest With Nonshockable Rhythm Trial Data Alexiane Blanc, Gwenhael Colin, Alain Cariou, et al Chest 2022; 162: 356-366 Published:March 19, 2022 DOI:https://doi.org/10.1016/j.chest.2022.02.056 Background Targeted temperature ma...

CRITICAL CARE: ORIGINAL RESEARCH| VOLUME 162, ISSUE 2, P331-345, AUGUST 01, 2022 The Influence of the COVID-19 Pandemic on Intensivists’ Well-Being: A Qualitative Study Kelly C. Vranas, Sara E. Golden, Shannon Nugent, et al Chest 2022; 162: 331-345 Published:May 11, 2022 DOI:https://doi.org/10.1016/j.chest.2022.05.003 Background The COVID-19 pandemic has strained health care systems and has resulted in widespread critical care staffing sho...

ARTICLES|ONLINE FIRST Phenotyping of idiopathic pulmonary arterial hypertension: a registry analysis Marius M Hoeper, Krit Dwivedi, Christine Pausch, et al. Lancet Respir Med Published:June 28, 2022 DOI:https://doi.org/10.1016/S2213-2600(22)00097-2 Summary Background Among patients meeting diagnostic criteria for idiopathic pulmonary arterial hypertension (IPAH), there is an emerging lung phenotype characterised by a low diffusion capacity f...

ARTICLES|ONLINE FIRST Association between women's authorship and women's editorship in infectious diseases journals: a cross-sectional study Katharina Last, Lilith Hübsch, Muge Cevik, et al. Lancet Infect Dis Published:July 12, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00367-X Summary Background Gender inequity is still pervasive in academic medicine, including journal publishing. We aimed to ascertain the proportion of women among first and last...

ARTICLES|ONLINE FIRST Impact of interactive computerised decision support for hospital antibiotic use (COMPASS): an open-label, cluster-randomised trial in three Swiss hospitals Gaud Catho, Julien Sauser, Valentina Coray, et al. Lancet Infect Dis Published:July 20, 2022 DOI:https://doi.org/10.1016/S1473-3099(22)00308-5 Summary Background Computerised decision-support systems (CDSSs) for antibiotic stewardship could help to assist physicians in the app...

ARTICLES| VOLUME 400, ISSUE 10349, P359-368, JULY 30, 2022 Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis RECOVERY Collaborative Group Lancet 2022; 400: 359-368 Published:July 30, 2022 DOI:https://doi.org/10.1016/S0140-6736(22)01109-6 Summary Background We aimed to evaluate the use of baricitinib, a Janus kinase (JAK) 1–2 inhibitor, fo...

ONLINE FIRST (FREE ACCESS) OPEN ACCESS ~ Original How doctors manage conflicts with families of critically ill patients during conversations about end-of-life decisions in neonatal, pediatric, and adult intensive careSpijkers A.S. et al. Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital c...

Research Letter  July 22, 2022 Association Between Vaccination and Acute Myocardial Infarction and Ischemic Stroke After COVID-19 Infection Young-Eun Kim, Kyungmin Huh, Young-Joon Park, et al JAMA. Published online July 22, 2022. doi:10.1001/jama.2022.12992 Studies have suggested an increased incidence of acute myocardial infarction (AMI) and ischemic stroke after COVID-19 infection related to an increased risk of thrombosis.1,2 Vaccines...

Original Investigation  July 7, 2022 Changes in the Relationship Between Income and Life Expectancy Before and During the COVID-19 Pandemic, California, 2015-2021 Hannes Schwandt, Janet Currie, Till von Wachter, et al JAMA. 2022;328(4):360-366. doi:10.1001/jama.2022.10952 Key Points Question  How did the first 2 years of the COVID-19 pandemic affect life expectancy in California and the relationship between census tract income and life exp...